Search Results - "DeRoy, Patrick L."

Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate by Ding, Hui, DeRoy, Patrick L., Perreault, Christian, Larivée, Alexandre, Siddiqui, Arshad, Caldwell, Charles G., Harran, Susan, Harran, Patrick G.

“…An electrochemical method to synthesize the core macrolactam of diazonamides is described. Large ring‐forming dehydrogenation is initiated by anodic oxidation…”
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Efficient Nucleophilic Aromatic Substitution between Aryl Nitrofluorides and Alkynes by DeRoy, Patrick L, Surprenant, Simon, Bertrand-Laperle, Megan, Yoakim, Christiane

“…The nucleophilic aromatic substitution reaction between electron-deficient aryl fluorides and terminal alkynes is shown to be efficiently promoted by sodium…”
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Thermal Nickel-Catalyzed N‑Arylation of NH-Sulfoximines with (Hetero)aryl Chlorides Enabled by PhPAd-DalPhos Ligation by Fisher, Samuel A., Simon, Connor M., Fox, Peter L., Cotnam, Michael J., DeRoy, Patrick L., Stradiotto, Mark

“…We report a versatile method for cross-coupling of NH-sulfoximines with (hetero)­aryl chlorides, as well as bromide and sulfonate electrophiles, that makes use…”
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Total Synthesis of (+)-Cystothiazole A by DeRoy, Patrick L, Charette, André B

“…The total synthesis of cystothiazole A is described. Key steps of the synthesis include an Evans asymmetric catalytic aldol reaction, which established the…”
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Electrolytic Macrocyclizations: Scalable Synthesis of a Diazonamide-Based Drug Development Candidate by Ding, Hui, DeRoy, Patrick L., Perreault, Christian, Larivée, Alexandre, Siddiqui, Arshad, Caldwell, Charles G., Harran, Susan, Harran, Patrick G.

“…An electrochemical method to synthesize the core macrolactam of diazonamides is described. Large ring‐forming dehydrogenation is initiated by anodic oxidation…”
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Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases by Gagnon, Alexandre, Amad, Ma’an H., Bonneau, Pierre R., Coulombe, René, DeRoy, Patrick L., Doyon, Louise, Duan, Jianmin, Garneau, Michel, Guse, Ingrid, Jakalian, Araz, Jolicoeur, Eric, Landry, Serge, Malenfant, Eric, Simoneau, Bruno, Yoakim, Christiane

“…The SAR and PK studies of a series of thiotetrazolyl akynylacetanilides as potent inhibitors of the HIV-1 RT is reported. A series of aryl…”
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Nickel-Catalyzed N‑Arylation of Sulfinamides: A Comparative Study versus Analogous Sulfonamide Cross-Couplings by Simon, Connor M., Robertson, Katherine N., DeRoy, Patrick L., Yadav, Arun A., Johnson, Erin R., Stradiotto, Mark

“…Despite recent progress regarding the metal-catalyzed C–N cross-coupling of (hetero)­aryl (pseudo)­halides with NH substrates, such transformations involving…”
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