Search Results - "DeRossi, Charles"

Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver by Morrison, Joshua K., DeRossi, Charles, Alter, Isaac L., Nayar, Shikha, Giri, Mamta, Zhang, Chi, Cho, Judy H., Chu, Jaime

“…The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been…”
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MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect by Shtraizent, Nataly, DeRossi, Charles, Nayar, Shikha, Sachidanandam, Ravi, Katz, Liora S, Prince, Adam, Koh, Anna P, Vincek, Adam, Hadas, Yoav, Hoshida, Yujin, Scott, Donald K, Eliyahu, Efrat, Freeze, Hudson H, Sadler, Kirsten C, Chu, Jaime

“…Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed…”
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Suppressor role of activating transcription factor 2 (ATF2) in skin cancer by Bhoumik, Anindita, Fichtman, Boris, DeRossi, Charles, Breitwieser, Wolfgang, Kluger, Harriet M, Davis, Sean, Subtil, Antonio, Meltzer, Paul, Krajewski, Stan, Jones, Nic, Ronai, Ze'ev

“…Activating transcription factor 2 (ATF2) regulates transcription in response to stress and growth factor stimuli. Here, we use a mouse model in which ATF2 was…”
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Ablation of Mouse Phosphomannose Isomerase (Mpi) Causes Mannose 6-Phosphate Accumulation, Toxicity, and Embryonic Lethality by DeRossi, Charles, Bode, Lars, Eklund, Erik A., Zhang, Fangrong, Davis, Joseph A., Westphal, Vibeke, Wang, Ling, Borowsky, Alexander D., Freeze, Hudson H.

“…MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis. MPI…”
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Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice by Sharma, Vandana, Nayak, Jonamani, DeRossi, Charles, Charbono, Adriana, Ichikawa, Mie, Ng, Bobby G., Grajales‐Esquivel, Erika, Srivastava, Anand, Wang, Ling, He, Ping, Scott, David A., Russell, Joseph, Contreras, Emily, Guess, Cherise M., Krajewski, Stan, Rio‐Tsonis, Katia Del, Freeze, Hudson H.

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Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans by DeRossi, Charles, Bambino, Kathryn, Morrison, Joshua, Sakarin, Isabel, Villacorta‐Martin, Carlos, Zhang, Changwen, Ellis, Jillian L., Fiel, M. Isabel, Ybanez, Maria, Lee, Youngmin A., Huang, Kuan‐lin, Yin, Chunyue, Sakaguchi, Takuya F., Friedman, Scott L., Villanueva, Augusto, Chu, Jaime

“…The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model…”
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Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice by Schneider, Anette, Thiel, Christian, Rindermann, Jan, DeRossi, Charles, Popovici, Diana, Hoffmann, Georg F, Gröne, Hermann-Josef, Körner, Christian

“…Congenital disorder of glycosylation-Ia in humans is a multisystemic disease marked by severe neurological deficits and results from deficient glycoprotein…”
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trappc11 is required for protein glycosylation in zebrafish and humans by DeRossi, Charles, Vacaru, Ana, Rafiq, Ruhina, Cinaroglu, Ayca, Imrie, Dru, Nayar, Shikha, Baryshnikova, Anastasia, Milev, Miroslav P, Stanga, Daniela, Kadakia, Dhara, Gao, Ningguo, Chu, Jaime, Freeze, Hudson H, Lehrman, Mark A, Sacher, Michael, Sadler, Kirsten C

“…Activation of the unfolded protein response (UPR) can be either adaptive or pathological. We term the pathological UPR that causes fatty liver disease a…”
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ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus by Michaud, Jacques L., DeRossi, Charles, May, Noah R., Holdener, Bernadette C., Fan, Chen-Ming

“…One major function of the hypothalamus is to maintain homeostasis by modulating the secretion of pituitary hormones. The paraventricular (PVN) and supraoptic…”
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TREM‐2, an innate immune receptor, is dependent on C/EBPalpha and PU.1 transcription factors during the differentiation of hematopoietic stem cells to macrophages by MANCARELLI, M.MICHELA, Derossi, Charles, Torbett, Bruce E

“…Triggering receptor on myeloid cells‐2 (TREM‐2) is a member of the innate immune signaling receptor TREM family, reportedly only expressed on macrophages,…”
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Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice by Sharma, Vandana, Nayak, Jonamani, DeRossi, Charles, Charbono, Adriana, Ichikawa, Mie, Ng, Bobby G., Grajales‐Esquivel, Erika, Srivastava, Anand, Wang, Ling, He, Ping, Scott, David A., Russell, Joseph, Contreras, Emily, Guess, Cherise M., Krajewski, Stan, Rio‐Tsonis, Katia Del, Freeze, Hudson H.

“…Patients with congenital disorder of glycosylation (CDG), type Ib (MPI‐CDG or CDG‐Ib) have mutations in phosphomannose isomerase (MPI) that impair…”
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Mesd Encodes an LRP5/6 Chaperone Essential for Specification of Mouse Embryonic Polarity by Hsieh, Jen-Chih, Lee, Lance, Zhang, Liqun, Wefer, Stephen, Brown, Kristen, DeRossi, Charles, Wines, Mary E., Rosenquist, Thomas, Holdener, Bernadette C.

“…Specification of embryonic polarity and pattern formation in multicellular organisms requires inductive signals from neighboring cells. One approach toward…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2 by Laiosa, Michael D., Lai, Zhi-Wei, Thurmond, T. Scott, Fiore, Nancy C., DeRossi, Charles, Holdener, Bernadette C., Gasiewicz, Thomas A., Silverstone, Allen E.

“…It is well established that dioxins cause a variety of toxic effects and syndromes including alterations of lymphocyte development. Exposure to the…”
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Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase by Davis, Joseph A., Wu, Xiao-Hua, Wang, Ling, DeRossi, Charles, Westphal, Vibeke, Wu, Rongrong, Alton, Gordon, Srikrishna, Geetha, Freeze, Hudson H.

“…Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation. We have…”
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MouseFzd4 maps within a region of chromosome 7 important for thymus and cardiac development by DeRossi, Charles, Laiosa, Michael D., Silverstone, Allen E., Holdener, Bernadette C.

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Identification of Mesoderm Development (mesd) Candidate Genes by Comparative Mapping and Genome Sequence Analysis by Wines, Mary E., Lee, Lance, Katari, Manpreet S., Zhang, Liqun, DeRossi, Charles, Shi, Ying, Perkins, Signa, Feldman, Michael, McCombie, W.Richard, Holdener, Bernadette C.

“…The proximal albino deletions identify several functional regions on mouse Chromosome 7 critical for differentiation of mesoderm (mesd), development of the…”
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Mouse Fzd4 maps within a region of chromosome 7 important for thymus and cardiac development by DeRossi, Charles, Laiosa, Michael D., Silverstone, Allen E., Holdener, Bernadette C.

“…The cardiac neural crest (CNC) plays a central role in development of the thymus gland and cardiovascular system. Through morphological and histological…”
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