Search Results - "DeRocher, Amy E."

Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption by Bouchut, Anne, Geiger, Jennifer A, DeRocher, Amy E, Parsons, Marilyn

“…Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast. Most apicoplast proteins are encoded in the…”
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An essential Trypanosoma brucei protein kinase: a functional analysis of regulation and the identification of inhibitors by Parsons, Marilyn, Parsons, Ben, Dean, Marissa, DeRocher, Amy E, Islam, Zeba, Maly, Dustin J, Jensen, Bryan C

“…The protein serine/threonine kinase AEK1 is essential in the pathogenic stage of Trypanosoma brucei, the causative agent of African trypanosomiasis. AEK1 is a…”
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A Thioredoxin Family Protein of the Apicoplast Periphery Identifies Abundant Candidate Transport Vesicles in Toxoplasma gondii by DeRocher, Amy E, Coppens, Isabelle, Karnataki, Anuradha, Gilbert, Luke A, Rome, Michael E, Feagin, Jean E, Bradley, Peter J, Parsons, Marilyn

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cytochrome P450-Dependent Metabolism of Oxylipins in Tomato. Cloning and Expression of Allene Oxide Synthase and Fatty Acid Hydroperoxide Lyase by Howe, Gregg A., Lee, Gyu In, Aya Itoh, Li, Lei, DeRocher, Amy E.

“…Allene oxide synthase (AOS) and fatty acid hydroperoxide lyase (HPL) are plant-specific cytochrome P450s that commit fatty acid hydroperoxides to different…”
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Xyloglucan fucosyltransferase, an enzyme involved in plant cell wall biosynthesis by Perrin, R.M, DeRocher, A.E, Bar-Peled, M, Zeng, W, Norambuena, L, Orellana, A, Raikhel, N.V, Keegstra, K

“…Cell walls are crucial for development, signal transduction, and disease resistance in plants. Cell walls are made of cellulose, hemicelluloses, and pectins…”
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Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis by Vidadala, Rama Subba Rao, Rivas, Kasey L, Ojo, Kayode K, Hulverson, Matthew A, Zambriski, Jennifer A, Bruzual, Igor, Schultz, Tracey L, Huang, Wenlin, Zhang, Zhongsheng, Scheele, Suzanne, DeRocher, Amy E, Choi, Ryan, Barrett, Lynn K, Siddaramaiah, Latha Kallur, Hol, Wim G. J, Fan, Erkang, Merritt, Ethan A, Parsons, Marilyn, Freiberg, Gail, Marsh, Kennan, Kempf, Dale J, Carruthers, Vern B, Isoherranen, Nina, Doggett, J. Stone, Van Voorhis, Wesley C, Maly, Dustin J

“…New therapies are needed for the treatment of toxoplasmosis, which is a disease caused by the protozoan parasite Toxoplasma gondii. To this end, we previously…”
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Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity by Johnson, Steven M, Murphy, Ryan C, Geiger, Jennifer A, DeRocher, Amy E, Zhang, Zhongsheng, Ojo, Kayode K, Larson, Eric T, Perera, B. Gayani K, Dale, Edward J, He, Panqing, Reid, Molly C, Fox, Anna M. W, Mueller, Natascha R, Merritt, Ethan A, Fan, Erkang, Parsons, Marilyn, Van Voorhis, Wesley C, Maly, Dustin J

“…Toxoplasmosis is a disease of prominent health concern that is caused by the protozoan parasite Toxoplasma gondii. Proliferation of T. gondii is dependent on…”
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Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors by Ojo, Kayode K, Larson, Eric T, Keyloun, Katelyn R, Castaneda, Lisa J, DeRocher, Amy E, Inampudi, Krishna K, Kim, Jessica E, Arakaki, Tracy L, Murphy, Ryan C, Zhang, Li, Napuli, Alberto J, Maly, Dustin J, Verlinde, Christophe L M J, Buckner, Frederick S, Parsons, Marilyn, Hol, Wim G J, Merritt, Ethan A, Van Voorhis, Wesley C

“…A family of calcium-dependent protein kinases (CDPK) is present in apicomplexan parasites but not in animals, indicating their potential as targets for…”
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Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis by Hulverson, Matthew A, Bruzual, Igor, McConnell, Erin V, Huang, Wenlin, Vidadala, Rama S R, Choi, Ryan, Arnold, Samuel L M, Whitman, Grant R, McCloskey, Molly C, Barrett, Lynn K, Rivas, Kasey L, Scheele, Suzanne, DeRocher, Amy E, Parsons, Marilyn, Ojo, Kayode K, Maly, Dustin J, Fan, Erkang, Van Voorhis, Wesley C, Doggett, J Stone

“…Abstract Bumped kinase inhibitors (BKIs) have been shown to be potent inhibitors of Toxoplasma gondii calcium-dependent protein kinase 1. Pyrazolopyrimidine…”
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Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays by Scheele, Suzanne, Geiger, Jennifer A, DeRocher, Amy E, Choi, Ryan, Smith, Tess R, Hulverson, Matthew A, Vidadala, Rama Subba Rao, Barrett, Lynn K, Maly, Dustin J, Merritt, Ethan A, Ojo, Kayode K, Van Voorhis, Wesley C, Parsons, Marilyn

“…In , calcium-dependent protein kinase 1 (CDPK1) is an essential protein kinase required for invasion of host cells. We have developed several hundred CDPK1…”
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Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy by Ojo, Kayode K., Dangoudoubiyam, Sriveny, Verma, Shiv K., Scheele, Suzanne, DeRocher, Amy E., Yeargan, Michelle, Choi, Ryan, Smith, Tess R., Rivas, Kasey L., Hulverson, Matthew A., Barrett, Lynn K., Fan, Erkang, Maly, Dustin J., Parsons, Marilyn, Dubey, Jitender P., Howe, Daniel K., Van Voorhis, Wesley C.

“…[Display omitted] •Sarcocystis neurona (Sn) CDPK1 has an atypical small gatekeeper residue selectively inhibited by BKIs.•Evidence is provided that shows…”
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Apicoplast Targeting of a Toxoplasma gondii Transmembrane Protein Requires a Cytosolic Tyrosine‐Based Motif by DeRocher, Amy E., Karnataki, Anuradha, Vaney, Pashmi, Parsons, Marilyn

“…Toxoplasma gondii, like most apicomplexan parasites, possesses an essential relict chloroplast, the apicoplast. Several apicoplast membrane proteins lack the…”
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A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway by Mailu, Boniface M, Ramasamay, Gowthaman, Mudeppa, Devaraja G, Li, Ling, Lindner, Scott E, Peterson, Megan J, DeRocher, Amy E, Kappe, Stefan H I, Rathod, Pradipsinh K, Gardner, Malcolm J

“…The malaria parasite Plasmodium falciparum and related organisms possess a relict plastid known as the apicoplast. Apicoplast protein synthesis is a validated…”
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Sequential processing of the Toxoplasma apicoplast membrane protein FtsH1 in topologically distinct domains during intracellular trafficking by Karnataki, Anuradha, DeRocher, Amy E., Feagin, Jean E., Parsons, Marilyn

“…FtsH proteins are hexameric transmembrane proteases found in chloroplasts, mitochondria and bacteria. In the protozoan Toxoplasma gondii, FtsH1 is localized to…”
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Membrane Protease is Targeted to the Relict Plastid of Toxoplasma via an Internal Signal Sequence by Karnataki, Anuradha, DeRocher, Amy E, Coppens, Isabelle, Feagin, Jean E, Parsons, Marilyn

“…The apicoplast is a secondary plastid found in Toxoplasma gondii, Plasmodium species and many other apicomplexan parasites. Although the apicoplast is…”
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SAR Studies of 5‑Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1 by Huang, Wenlin, Ojo, Kayode K, Zhang, Zhongsheng, Rivas, Kasey, Vidadala, Rama Subba Rao, Scheele, Suzanne, DeRocher, Amy E, Choi, Ryan, Hulverson, Matthew A, Barrett, Lynn K, Bruzual, Igor, Siddaramaiah, Latha Kallur, Kerchner, Keshia M, Kurnick, Matthew D, Freiberg, Gail M, Kempf, Dale, Hol, Wim G. J, Merritt, Ethan A, Neckermann, Georg, de Hostos, Eugenio L, Isoherranen, Nina, Maly, Dustin J, Parsons, Marilyn, Doggett, J. Stone, Van Voorhis, Wesley C, Fan, Erkang

“…We previously discovered compounds based on a 5-aminopyrazole-4-carboxamide scaffold to be potent and selective inhibitors of CDPK1 from T. gondii. The current…”
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Evolving Insights into Protein Trafficking to the Multiple Compartments of the Apicomplexan Plastid by PARSONS, MARILYN, KARNATAKI, ANURADHA, DEROCHER, AMY E

“…The apicoplast is a relict plastid found in many medically important apicomplexan parasites, such as Plasmodium and Toxoplasma. Phylogenetic analysis and the…”
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Expression of a conserved family of cytoplasmic low molecular weight heat shock proteins during heat stress and recovery by DeRocher, A.E. (University of Arizona, Tucson, AZ), Helm, K.W, Lauzon, L.M, Vierling, E

“…Plants synthesize several families of low molecular weight (LMW) heat shock proteins (HSPs) in response to elevated temperatures. We have characterized two…”
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Evolving Insights into Protein Trafficking to the Multiple Compartments of the Apicomplexan Plastid1 by PARSONS, MARILYN, KARNATAKI, ANURADHA, DEROCHER, AMY E.

“…The apicoplast is a relict plastid found in many medically important apicomplexan parasites, such as Plasmodium and Toxoplasma. Phylogenetic analysis and the…”
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Apicoplast targeting of a T. gondii transmembrane protein requires a cytosolic tyrosine-based motif by DeRocher, Amy E., Karnataki, Anuradha, Vaney, Pashmi, Parsons, Marilyn

“…Toxoplasma gondii, like most apicomplexan parasites, possesses a nessential relict chloroplast, the apicoplast. Several apicoplast membrane proteins lack the…”
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