Search Results - "DePrimo, S E"

Clinical evaluation of continuous daily dosing of sunitinib malate in patients with advanced gastrointestinal stromal tumour after imatinib failure by George, S, Blay, J.Y, Casali, P.G, Le Cesne, A, Stephenson, P, DePrimo, S.E, Harmon, C.S, Law, C.N.J, Morgan, J.A, Ray-Coquard, I, Tassell, V, Cohen, D.P, Demetri, G.D

“…Abstract Aims To assess the antitumour activity, safety, pharmacokinetics and pharmacodynamics of continuous daily sunitinib dosing in patients with…”
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Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib by DePrimo, SE, Bello, C

“…Conventional methods to assess the clinical activity of new agents that target specific biological pathways involved in tumour pathology may not provide…”
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Circulating cytokines and monocyte subpopulations as biomarkers of outcome and biological activity in sunitinib-treated patients with advanced neuroendocrine tumours by Zurita, A J, Khajavi, M, Wu, H-K, Tye, L, Huang, X, Kulke, M H, Lenz, H-J, Meropol, N J, Carley, W, DePrimo, S E, Lin, E, Wang, X, Harmon, C S, Heymach, J V

“…Background: Sunitinib is approved worldwide for treatment of advanced pancreatic neuroendocrine tumours (pNET), but no validated markers exist to predict…”
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Regulation of p53 expression by the RAS-MAP kinase pathway by AGARWAL, Munna L, RAMANA, Chilakamarti V, HAMILTON, Mark, TAYLOR, William R, DEPRIMO, Samuel E, BEAN, Lora J. H, AGARWAL, Archana, AGARWAL, Mukesh K, WOLFMAN, Alan, STARK, George R

“…Activation of MAP kinase leads to the activation of p53-dependent pathways, and vice-versa. Although the amount of p53 protein increases in response to MAP…”
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Human placental alkaline phosphatase as a histochemical marker of gene expression in transgenic mice by DEPRIMO, S. E, STAMBROOK, P. J, STRINGER, J. R

“…The human placental alkaline phosphatase (PLAP) gene was analysed for its utility as a histochemically detectable reporter gene in transgenic mice. A reporter…”
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Mechanisms of G2 arrest in response to overexpression of p53 by Taylor, W R, DePrimo, S E, Agarwal, A, Agarwal, M L, Schönthal, A H, Katula, K S, Stark, G R

“…Overexpression of p53 causes G2 arrest, attributable in part to the loss of CDC2 activity. Transcription of cdc2 and cyclin B1, determined using reporter…”
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Cell cycle dependence of radiation-induced homologous recombination in cultured monkey cells by Cao, J, DePrimo, S E, Stringer, J R

“…A lacZ transgene recombination system that reports homologous recombination events involving duplicated lacZ segments was used to study recombination in monkey…”
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Prevention of prostate cancer by DePrimo, S E, Shinghal, R, Vidanes, G, Brooks, J D

“…Strategies for reducing the occurrence of prostate cancers will be critical in limiting the morbidity and mortality of this disease. The long latency period of…”
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Use of human placental alkaline phosphatase transgenes to detect somatic mutation in mice in situ by DePrimo, S E, Cao, J, Hersh, M N, Stringer, J R

“…Methods for in situ detection of cells that have suffered a specific mutation would be valuable for understanding somatic genetic mosaicism, a phenomenon that…”
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Circulating protein and cellular biomarkers of sunitinib in patients with advanced neuroendocrine tumors by Zurita, A. J., Heymach, J., Khajavi, M., Tye, L., Huang, X., Kulke, M., Lenz, H., Meropol, N. J., Carley, W., DePrimo, S. E., Harmon, C. S.

“…Abstract only…”
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Activity of SU11248, a Multitargeted Inhibitor of Vascular Endothelial Growth Factor Receptor and Platelet-Derived Growth Factor Receptor, in Patients With Metastatic Renal Cell Carcinoma by MOTZER, Robert J, MICHAELSON, M. Dror, LI, Jim Z, BELLO, Carlo L, THEUER, Charles P, GEORGE, Daniel J, RINI, Brian I, REDMAN, Bruce G, HUDES, Gary R, WILDING, George, FIGLIN, Robert A, GINSBERG, Michelle S, KIM, Sindy T, BAUM, Charles M, DEPRIMO, Samuel E

“…Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in high expression of pro-angiogenic growth…”
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Circulating biomarkers of sunitinib in patients with unresectable hepatocellular carcinoma (HCC): Analysis of correlations with outcome and tumor imaging parameters by DePrimo, S. E., Cheng, A., Lanzalone, S., Lechuga, M. J., Harmon, C. S., Lin, X., Raymond, E., Faivre, S. J.

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Continuous daily dosing (CDD) of sunitinib (SU) in pts with advanced GIST: Updated efficacy, safety, PK and pharmacodynamic analysis by George, S., Blay, J. Y., Casali, P. G., Le Cesne, A., DePrimo, S. E., Harmon, C. S., Law, C. N., Tassell, V., Baum, C. M., Demetri, G. D.

“…Abstract only…”
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Evaluation of soluble KIT (sKIT) as a potential surrogate marker for TTP in sunitinib malate (SU)-treated patients (pts) with advanced GIST by Blackstein, M., Huang, X., Demetri, G. D., Casali, P. G., Garrett, C. R., Schöffski, P., Shah, M. H., Verweij, J., Baum, C. M., DePrimo, S. E.

“…Abstract only 10007 Background: SU is an oral, multitargeted tyrosine kinase inhibitor of KIT, PDGFRs, VEGFRs, RET and FLT3, approved multinationally for the…”
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Effect of treatment with sunitinib malate, a multitargeted tyrosine kinase inhibitor, on circulating plasma levels of VEGF, soluble VEGF receptors 2 and 3, and soluble KIT in patients with metastatic breast cancer by Deprimo, S. E., Friece, C., Huang, X., Smeraglia, J., Sherman, L., Collier, M., Baum, C., Elias, A. D., Burstein, H. J., Miller, K. D.

“…Abstract only 578 Background: Sunitinib malate (SU11248) is a multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activity that…”
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Analysis of circulating biomarkers of sunitinib malate in patients with unresectable neuroendocrine tumors (NET): VEGF, IL-8, and soluble VEGF receptors 2 and 3 by Bello, C., Deprimo, S. E., Friece, C., Smeraglia, J., Sherman, L., Tye, L., Baum, C., Meropol, N. J., Lenz, H., Kulke, M. H.

“…Abstract only 4045 Background: Sunitinib malate (SU11248) is a multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activity that…”
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Levels of circulating endothelial cells (CECs) and monocytes as pharmacodynamic markers of SU11248 activity in patients (pts) with metastatic imatinib-resistant GIST by Norden-Zfoni, A., Manola, J., Desai, J., Morgan, J., Bello, C. L., Deprimo, S. E., Shalinsky, D. R., Baum, C., Demetri, G. D., Heymach, J.

“…Abstract only…”
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Resveratrol-Induced Gene Expression Profiles in Human Prostate Cancer Cells by JONES, Sunita B, DEPRIMO, Samuel E, WHITFIELD, Michael L, BROOKS, James D

“…Objective: The transhydroxystilbene resveratrol is found at high levels in red wine and grapes, and red wine consumption may be inversely associated with…”
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Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial Cells by Schwarze, Steven R, DePrimo, Samuel E, Grabert, Lisa M, Fu, Vivian X, Brooks, James D, Jarrard, David F

“…Cellular senescence forms a barrier that inhibits the acquisition of an immortal phenotype, a critical feature in tumorigenesis. The inactivation of multiple…”
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Reg IV: A Promising Marker of Hormone Refractory Metastatic Prostate Cancer by Gu, Zhennan, Rubin, Mark A, Yang, Yu, Deprimo, Samuel E, Zhao, Hongjuan, Horvath, Steven, Brooks, James D, Loda, Massimo, Reiter, Robert E

“…The diagnosis and management of prostate cancer is hampered by the absence of markers capable of identifying patients with metastatic disease. In order to…”
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