Search Results - "DeNardo, David G."

Tumor-associated fibrosis as a regulator of tumor immunity and response to immunotherapy by Jiang, Hong, Hegde, Samarth, DeNardo, David G.

“…Tumor-associated fibrosis is characterized by unchecked pro-fibrotic and pro-inflammatory signaling. The components of fibrosis including significant numbers…”
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A framework for advancing our understanding of cancer-associated fibroblasts by Sahai, Erik, Astsaturov, Igor, Cukierman, Edna, DeNardo, David G., Egeblad, Mikala, Evans, Ronald M., Fearon, Douglas, Greten, Florian R., Hingorani, Sunil R., Hunter, Tony, Hynes, Richard O., Jain, Rakesh K., Janowitz, Tobias, Jorgensen, Claus, Kimmelman, Alec C., Kolonin, Mikhail G., Maki, Robert G., Powers, R. Scott, Puré, Ellen, Ramirez, Daniel C., Scherz-Shouval, Ruth, Sherman, Mara H., Stewart, Sheila, Tlsty, Thea D., Tuveson, David A., Watt, Fiona M., Weaver, Valerie, Weeraratna, Ashani T., Werb, Zena

“…Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling,…”
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Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy by Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G

“…DeNardo and colleagues report that inhibiting focal adhesion kinase in pancreatic ductal adenocarcinoma (PDAC) in mice reduces fibrosis and improves the…”
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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer by Hegde, Samarth, Krisnawan, Varintra E., Herzog, Brett H., Zuo, Chong, Breden, Marcus A., Knolhoff, Brett L., Hogg, Graham D., Tang, Jack P., Baer, John M., Mpoy, Cedric, Lee, Kyung Bae, Alexander, Katherine A., Rogers, Buck E., Murphy, Kenneth M., Hawkins, William G., Fields, Ryan C., DeSelm, Carl J., Schwarz, Julie K., DeNardo, David G.

“…Here, we utilized spontaneous models of pancreatic and lung cancer to examine how neoantigenicity shapes tumor immunity and progression. As expected,…”
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Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity by DeNardo, David G., Andreu, Pauline, Coussens, Lisa M.

“…Tumor-associated myeloid cells have been implicated in regulating many of the “hallmarks of cancer” and thus fostering solid tumor development and metastasis…”
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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis by Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.

“…Age is a significant risk factor for the development of cancer. However, the mechanisms that drive age-related increases in cancer remain poorly understood. To…”
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Rethinking immune checkpoint blockade: ‘Beyond the T cell’ by Liu, Xiuting, Hogg, Graham D, DeNardo, David G

“…The clinical success of immune checkpoint inhibitors has highlighted the central role of the immune system in cancer control. Immune checkpoint inhibitors can…”
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Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial by Nywening, Timothy M, MD, Wang-Gillam, Andrea, MD, Sanford, Dominic E, MD, Belt, Brian A, MA, Panni, Roheena Z, MD, Cusworth, Brian M, BA, Toriola, Adetunji T, MD, Nieman, Rebecca K, MS, Worley, Lori A, BS, Yano, Motoyo, MD, Fowler, Kathryn J, MD, Lockhart, A Craig, MD, Suresh, Rama, MD, Tan, Benjamin R, MD, Lim, Kian-Huat, MD, Fields, Ryan C, MD, Strasberg, Steven M, Prof, Hawkins, William G, Prof, DeNardo, David G, PhD, Goedegebuure, S Peter, PhD, Linehan, David C, Dr Prof

“…Summary Background In pancreatic ductal adenocarcinoma, the CCL2–CCR2 chemokine axis is used to recruit tumour-associated macrophages for construction of an…”
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Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses by MITCHEM, Jonathan B, BRENNAN, Donal J, HEWITT, Stephen, MALLYA UDUPI, Girish, GALLAGHER, William M, WEGNER, Craig, WEST, Brian L, WANG-GILLAM, Andrea, GOEDEGEBUURE, Peter, LINEHAN, David C, DENARDO, David G, KNOLHOFF, Brett L, BELT, Brian A, YU ZHU, SANFORD, Dominic E, BELAYGOROD, Larisa, CARPENTER, Danielle, COLLINS, Lynne, PIWNICA-WORMS, David

“…Tumor-infiltrating immune cells can promote chemoresistance and metastatic spread in aggressive tumors. Consequently, the type and quality of immune responses…”
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Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression by DeNardo, David G, Coussens, Lisa M

“…Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial…”
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Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance by Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.

“…Tumors employ multiple mechanisms to evade immune surveillance. One mechanism is tumor-induced myelopoiesis, whereby the expansion of immunosuppressive myeloid…”
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Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis by SANFORD, Dominic E, BELT, Brian A, WANG-GILLAM, Andrea, EBERLEIN, Timothy J, DENARDO, David G, GOEDEGEBUURE, Simon Peter, LINEHAN, David C, PANNI, Roheena Z, MAYER, Allese, DESHPANDE, Anjali D, CARPENTER, Danielle, MITCHEM, Jonathan B, PLAMBECK-SUESS, Stacey M, WORLEY, Lori A, GOETZ, Brian D

“…To determine the role of the CCL2/CCR2 axis and inflammatory monocytes (CCR2(+)/CD14(+)) as immunotherapeutic targets in the treatment of pancreatic cancer…”
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Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer by D'Amico, Lucia, Mahajan, Sahil, Capietto, Aude-Hélène, Yang, Zhengfeng, Zamani, Ali, Ricci, Biancamaria, Bumpass, David B, Meyer, Melissa, Su, Xinming, Wang-Gillam, Andrea, Weilbaecher, Katherine, Stewart, Sheila A, DeNardo, David G, Faccio, Roberta

“…Tumor-stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of…”
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Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy by DeNardo, David G, Brennan, Donal J, Rexhepaj, Elton, Ruffell, Brian, Shiao, Stephen L, Madden, Stephen F, Gallagher, William M, Wadhwani, Nikhil, Keil, Scott D, Junaid, Sharfaa A, Rugo, Hope S, Hwang, E Shelley, Jirström, Karin, West, Brian L, Coussens, Lisa M

“…Immune-regulated pathways influence multiple aspects of cancer development. In this article we demonstrate that both macrophage abundance and T-cell abundance…”
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Macrophages as regulators of tumour immunity and immunotherapy by DeNardo, David G., Ruffell, Brian

“…Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This…”
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Targeting tumor-infiltrating macrophages to combat cancer by Panni, Roheena Z, Linehan, David C, DeNardo, David G

“…Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence…”
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Polarized immune responses differentially regulate cancer development by Johansson, Magnus, DeNardo, David G, Coussens, Lisa M

“…Tumor-associated immune responses assert varied responses toward developing neoplasms that can either act to eradicate malignant cells via engagement of potent…”
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The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis by Corsa, Callie A.S., Brenot, Audrey, Grither, Whitney R., Van Hove, Samantha, Loza, Andrew J., Zhang, Kun, Ponik, Suzanne M., Liu, Yuming, DeNardo, David G., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

“…High levels of collagen deposition in human and mouse breast tumors are associated with poor outcome due to increased local invasion and distant metastases…”
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Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer by Panni, Roheena Z., Sanford, Dominic E., Belt, Brian A., Mitchem, Jonathan B., Worley, Lori A., Goetz, Brian D., Mukherjee, Pinku, Wang-Gillam, Andrea, Link, Daniel C., DeNardo, David G., Goedegebuure, S. Peter, Linehan, David C.

“…Pancreatic cancer (PC) mobilizes myeloid cells from the bone marrow to the tumor where they promote tumor growth and proliferation. Cancer stem cells (CSCs)…”
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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors by Uzhachenko, Roman V., Bharti, Vijaya, Ouyang, Zhufeng, Blevins, Ashlyn, Mont, Stacey, Saleh, Nabil, Lawrence, Hunter A., Shen, Chengli, Chen, Sheau-Chiann, Ayers, Gregory D., DeNardo, David G., Arteaga, Carlos, Richmond, Ann, Vilgelm, Anna E.

“…Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) delay progression of metastatic breast cancer. However, complete responses are uncommon and tumors…”
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