Search Results - "DeMattos, R B"

Biochemical analysis of cell-derived apoE3 particles active in stimulating neurite outgrowth by DeMattos, R B, Rudel, L L, Williams, D L

“…Susceptibility to the development of late-onset Alzheimer's disease is increased for individuals harboring one or more apolipoprotein E4 (apoE4) alleles…”
Get full text

Brain to Plasma Amyloid-β Efflux: A Measure of Brain Amyloid Burden in a Mouse Model of Alzheimer's Disease by DeMattos, Ronald B., Bales, Kelly R., Cummins, David J., Paul, Steven M., Holtzman, David M.

“…The deposition of amyloid-β (Aβ) peptides into amyloid plaques precedes the cognitive dysfunction of Alzheimer's disease (AD) by years. Biomarkers indicative…”
Get full text

Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease by DeMattos, R B, Bales, K R, Cummins, D J, Dodart, J C, Paul, S M, Holtzman, D M

“…Active immunization with the amyloid β (Aβ) peptide has been shown to decrease brain Aβ deposition in transgenic mouse models of Alzheimer's disease and…”
Get full text

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model by Paul, Steven M, Dodart, Jean-Cosme, Bales, Kelly R, Gannon, Kimberley S, Greene, Stephen J, DeMattos, Ronald B, Mathis, Chantal, DeLong, Cynthia A, Wu, Su, Wu, Xin, Holtzman, David M

“…We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta -peptide (A beta ), increases plasma…”
Get full text

ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo by DeMattos, Ronald B, Cirrito, John R, Parsadanian, Maia, May, Patrick C, O'Dell, Mark A, Taylor, Jennie W, Harmony, Judith A.K, Aronow, Bruce J, Bales, Kelly R, Paul, Steven M, Holtzman, David M

“…Apolipoprotein E (apoE) and clusterin can influence structure, toxicity, and accumulation of the amyloid-β (Aβ) peptide in brain. Both molecules may also be…”
Get full text

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life by Cirrito, John R, May, Patrick C, O'Dell, Mark A, Taylor, Jennie W, Parsadanian, Maia, Cramer, Jeffrey W, Audia, James E, Nissen, Jeffrey S, Bales, Kelly R, Paul, Steven M, DeMattos, Ronald B, Holtzman, David M

“…Soluble amyloid-beta (Abeta) peptide converts to structures with high beta-sheet content in Alzheimer's disease (AD). Soluble Abeta is released by neurons into…”
Get full text

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action by Haubenwallner, S, Essenburg, A.D., Barnett, B.C., Pape, M.E., DeMattos, R.B., Krause, B.R., Minton, L.L., Auerbach, B.J., Newton, R.S., Leff, T

“…For the last 30 years fibrates have been widely prescribed to treat human dyslipidemia. However, the primary mechanism by which they lower plasma lipid levels…”
Get full text

Tissue specific changes in acyl-CoA: cholesterol acyltransferase (ACAT) mRNA levels in rabbits by Pape, M E, Schultz, P A, Rea, T J, DeMattos, R B, Kieft, K, Bisgaier, C L, Newton, R S, Krause, B R

“…A human cDNA clone (K1) was recently isolated that encodes functional acyl-CoA:cholesterol acyltransferase (ACAT) protein (Chang et al. J. Biol. Chem. 1993…”
Get full text

Hepatic expression of genes regulating lipid metabolism in rabbits by Rea, T.J, DeMattos, R.B, Pape, M.E

“…The liver plays a central role in lipid metabolism and plasma lipoprotein homeostasis. This dynamic process is regulated by a variety of liver-derived…”
Get full text

Clusterin Promotes Amyloid Plaque Formation and is Critical for Neuritic Toxicity in a Mouse Model of Alzheimer's Disease by DeMattos, Ronald B., O'dell, Mark A., Parsadanian, Maia, Taylor, Jennie W., Judith A. K. Harmony, Bales, Kelly R., Paul, Steven M., Aronow, Bruce J., Holtzman, David M.

“…Studies have shown that clusterin (also called apolipoprotein J) can influence the structure and toxicity of amyloid-β (Aβ) in vitro. To determine whether…”
Get full text

Plaque‐associated disruption of CSF and plasma amyloid‐β (Aβ) equilibrium in a mouse model of Alzheimer's disease by DeMattos, Ronald B., Bales, Kelly R., Parsadanian, Maia, O'Dell, Mark A., Foss, Eric M., Paul, Steven M., Holtzman, David M.

“…To better understand amyloid‐β (Aβ) metabolism in vivo, we assessed the concentration of Aβ in the CSF and plasma of APPV717F (PDAPP) transgenic mice, a model…”
Get full text

Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice by Fryer, John D, Taylor, Jennie W, DeMattos, Ronald B, Bales, Kelly R, Paul, Steven M, Parsadanian, Maia, Holtzman, David M

“…Cerebral amyloid angiopathy (CAA) is a common cause of brain hemorrhage in the elderly. It is found in the majority of patients with Alzheimer's disease (AD)…”
Get full text

Effect of Different Anti-Aβ Antibodies on Aβ Fibrillogenesis as Assessed by Atomic Force Microscopy by Legleiter, Justin, Czilli, Dan L., Gitter, Bruce, DeMattos, Ronald B., Holtzman, David M., Kowalewski, Tomasz

“…Extensive data suggest that the conversion of the amyloid- beta (A beta ) peptide from soluble to insoluble forms is a key factor in the pathogenesis of…”
Get full text

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia by Holtzman, David M, Han, Byung Hee, DeMattos, Ronald B, Dugan, Laura L, Kim-Han, Jeong Sook, Brendza, Robert P, Fryer, John D, Kierson, Malca, Cirrito, John, Quick, Kevin, Harmony, Judith A. K, Aronow, Bruce J

“…Clusterin, also known as apolipoprotein J, is a ubiquitously expressed molecule thought to influence a variety of processes including cell death. In the brain,…”
Get full text

Scavenger Receptor Class B, Type I (SR-BI) is the Major Route for the Delivery of High Density Lipoprotein Cholesterol to the Steroidogenic Pathway in Cultured Mouse Adrenocortical Cells by Temel, Ryan E., Trigatti, Bernardo, DeMattos, Ronald B., Azhar, Salman, Krieger, Monty, Williams, David L.

“…The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured…”
Get full text

Rabbit liver apolipoprotein A-I synthesis is under nonparenchymal cell paracrine control by Rea, T J, Bisgaier, C L, DeMattos, R B, Pape, M E

“…Apolipoprotein A-I (apoA-I), the primary protein of high density lipoprotein, originates from intestine and liver of almost all mammalian species. In contrast…”
Get full text

Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease by DeMattos, Ronald B

“…Susceptibility to the development of Alzheimer's disease (AD) is increased for individuals harboring one or more apolipoprotein E4 (apoE4) alleles. Even though…”
Get full text

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice by DeMattos, Ronald B, Brendza, Robert P, Heuser, John E, Kierson, Malca, Cirrito, John R, Fryer, John, Sullivan, Patrick M, Fagan, Anne M, Han, Xianlin, Holtzman, David M

“…The ε4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease (AD). In order to gain a better understanding of the molecular…”
Get full text

Apolipoprotein E, Amyloid, and Alzheimer Disease by Bales, K R, Dodart, J C, DeMattos, R B, Holtzman, D M, Paul, S M

“…The alleles for apolipoprotein E (apoE) represent important genetic risk factors for the most common late-onset forms of Alzheimer disease (AD), with the ε 4…”
Get full text

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins by DeMattos, R B, Curtiss, L K, Williams, D L

“…Within the central nervous system, apolipoprotein E (apoE) synthesis is increased in response to nerve injury, a finding that may reflect a role for apoE in…”
Get full text