Search Results - "DeMaria, Carla D."
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Unified mechanisms of Ca2+ regulation across the Ca2+ channel family
Published in Neuron (Cambridge, Mass.) (11-09-2003)“…L-type (CaV1.2) and P/Q-type (CaV2.1) calcium channels possess lobe-specific CaM regulation, where Ca2+ binding to one or the other lobe of CaM triggers…”
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Engineered Calmodulins Reveal the Unexpected Eminence of Ca2+Channel Inactivation in Controlling Heart Excitation
Published in Proceedings of the National Academy of Sciences - PNAS (24-12-2002)“…Engineered calmodulins (CaMs), rendered Ca2+-insensitive by mutations, function as dominant negatives in heterologous systems, and have revealed mechanisms of…”
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3
Alternative Splicing as a Molecular Switch for Ca2+/Calmodulin-Dependent Facilitation of P/Q-Type Ca2+ Channels
Published in The Journal of neuroscience (14-07-2004)“…Alternative splicing of the P/Q-type channel (Ca(V)2.1) promises customization of the computational repertoire of neurons. Here we report that concerted…”
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4
Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels
Published in Nature (London) (24-05-2001)“…Acute modulation of P/Q-type (alpha1A) calcium channels by neuronal activity-dependent changes in intracellular Ca2+ concentration may contribute to short-term…”
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5
N-Type Calcium Channel Inactivation Probed by Gating-Current Analysis
Published in Biophysical journal (01-05-1999)“…N-type calcium channels inactivate most rapidly in response to moderate, not extreme depolarization. This behavior reflects an inactivation rate that bears a…”
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Systematic Identification of Splice Variants in Human P/Q-Type Channel α12.1 Subunits: Implications for Current Density and Ca2+-Dependent Inactivation
Published in The Journal of neuroscience (01-12-2002)“…P/Q-type (Ca v 2.1) calcium channels support a host of Ca 2+ -driven neuronal functions in the mammalian brain. Alternative splicing of the main α 1A (α 1 2.1)…”
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7
Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels
Published in Neuron (Cambridge, Mass.) (01-03-1999)“…Elevated intracellular Ca2+ triggers inactivation of L-type calcium channels, providing negative Ca2+ feedback in many cells. Ca2+ binding to the main alpha1c…”
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Ca(2+) channel modulation by recombinant auxiliary beta subunits expressed in young adult heart cells
Published in Circulation research (04-02-2000)“…L-type Ca(2+) channels contribute importantly to the normal excitation-contraction coupling of physiological hearts, and to the functional derangement seen in…”
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Ca2 Channel Modulation by Recombinant Auxiliary β Subunits Expressed in Young Adult Heart Cells
Published in Circulation research (04-02-2000)“…ABSTRACTL-type Ca channels contribute importantly to the normal excitation-contraction coupling of physiological hearts, and to the functional derangement seen…”
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10
Alternative Splicing as a Molecular Switch for Ca 2+ /Calmodulin-Dependent Facilitation of P/Q-Type Ca 2+ Channels
Published in The Journal of neuroscience (14-07-2004)“…Alternative splicing of the P/Q-type channel (Ca V 2.1) promises customization of the computational repertoire of neurons. Here we report that concerted…”
Get full text
Journal Article -
11
Alternative Splicing as a Molecular Switch for Ca super(2+)/Calmodulin-Dependent Facilitation of P/Q-Type Ca super(2+) Channels
Published in The Journal of neuroscience (14-07-2004)“…Alternative splicing of the P/Q-type channel (Ca sub(V)2.1) promises customization of the computational repertoire of neurons. Here we report that concerted…”
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Journal Article -
12
Engineered calmodulins reveal the unexpected eminence of Ca 2+ channel inactivation in controlling heart excitation
Published in Proceedings of the National Academy of Sciences - PNAS (24-12-2002)“…Engineered calmodulins (CaMs), rendered Ca 2+ -insensitive by mutations, function as dominant negatives in heterologous systems, and have revealed mechanisms…”
Get full text
Journal Article -
13
Unified Mechanisms of Ca 2+ Regulation across the Ca 2+ Channel Family
Published in Neuron (Cambridge, Mass.) (2003)“…L-type (Ca V1.2) and P/Q-type (Ca V2.1) calcium channels possess lobe-specific CaM regulation, where Ca 2+ binding to one or the other lobe of CaM triggers…”
Get full text
Journal Article -
14
Calmodulin bifurcates the local Ca 2+ signal that modulates P/Q-type Ca 2+ channels
Published in Nature (London) (24-05-2001)“…Acute modulation of P/Q-type (α1A) calcium channels by neuronal activity-dependent changes in intracellular Ca2+ concentration may contribute to short-term…”
Get full text
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Calmodulin bifurcates the local calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels
Published in Nature (London) (2001)Get full text
Journal Article -
17
Calmodulin Is the Ca 2+ Sensor for Ca 2+-Dependent Inactivation of L-Type Calcium Channels
Published in Neuron (Cambridge, Mass.) (1999)“…Elevated intracellular Ca 2+ triggers inactivation of L-type calcium channels, providing negative Ca 2+ feedback in many cells. Ca 2+ binding to the main α 1C…”
Get full text
Journal Article -
18
Ca2+ channel modulation by recombinant auxillary beta subunits expressed in young adult heart cells
Published in Circulation research (04-02-2000)“…L-type Ca(2+) channels contribute importantly to the normal excitation-contraction coupling of physiological hearts, and to the functional derangement seen in…”
Get full text
Journal Article -
19
Calmodulin bifurcates the local Ca super(2+) signal that modulates P/Q-type Ca super(2+) channels
Published in Nature (London) (24-05-2001)“…Acute modulation of P/Q-type ( alpha sub(1A)) calcium channels by neuronal activity-dependent changes in intracellular Ca super(2+) concentration may…”
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Journal Article -
20
Ca 2+ Channel Modulation by Recombinant Auxiliary β Subunits Expressed in Young Adult Heart Cells
Published in Circulation research (04-02-2000)“…Abstract —L-type Ca 2+ channels contribute importantly to the normal excitation-contraction coupling of physiological hearts, and to the functional derangement…”
Get full text
Journal Article