Search Results - "DeMAYO, FRANCESCO J"

Uterine Glands: Developmental Biology and Functional Roles in Pregnancy by Kelleher, Andrew M, DeMayo, Francesco J, Spencer, Thomas E

“…All mammalian uteri contain glands in the endometrium that develop only or primarily after birth. Gland development or adenogenesis in the postnatal uterus is…”
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The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network by Wetendorf, Margeaux, DeMayo, Francesco J.

“…► We describe the progesterone regulated paracrine signaling in early pregnancy. ► We discuss the affect of progesterone signaling on uterine gland…”
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Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis by Han, Sang Jun, Jung, Sung Yun, Wu, San-Pin, Hawkins, Shannon M., Park, Mi Jin, Kyo, Satoru, Qin, Jun, Lydon, John P., Tsai, Sophia Y., Tsai, Ming-Jer, DeMayo, Francesco J., O’Malley, Bert W.

“…Alterations in estrogen-mediated cellular signaling play an essential role in the pathogenesis of endometriosis. In addition to higher estrogen receptor (ER) β…”
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FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation by Vasquez, Yasmin M, Wang, Xiaoqiu, Wetendorf, Margeaux, Franco, Heather L, Mo, Qianxing, Wang, Tianyuan, Lanz, Rainer B, Young, Steven L, Lessey, Bruce A, Spencer, Thomas E, Lydon, John P, DeMayo, Francesco J

“…Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience…”
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The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling by Large, Michael J., DeMayo, Francesco J.

“…► In this review we discuss mediators and effectors of progesterone signaling. ► We collate data and insights gained from many mouse models. ► We discuss…”
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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer by Alam, Hunain, Tang, Ming, Maitituoheti, Mayinuer, Dhar, Shilpa S., Kumar, Manish, Han, Chae Young, Ambati, Chandrashekar R., Amin, Samir B., Gu, Bingnan, Chen, Tsai-Yu, Lin, Yu-Hsi, Chen, Jichao, Muller, Florian L., Putluri, Nagireddy, Flores, Elsa R., DeMayo, Francesco J., Baseler, Laura, Rai, Kunal, Lee, Min Gyu

“…Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their tumor-suppressive roles are poorly characterized. Histone…”
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Progesterone receptor signaling in the initiation of pregnancy and preservation of a healthy uterus by Wetendorf, Margeaux, DeMayo, Francesco J

“…Infertility and reproductive-associated disease are global problems in the world today affecting millions of women. A successful pregnancy requires a healthy…”
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Forkhead box a2 (FOXA2) is essential for uterine function and fertility by Kelleher, Andrew M., Peng, Wang, Pru, James K., Pru, Cindy A., DeMayo, Francesco J., Spencer, Thomas E.

“…Establishment of pregnancy is a critical event, and failure of embryo implantation and stromal decidualization in the uterus contribute to significant numbers…”
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Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy by Lynch, Vincent J., Nnamani, Mauris C., Kapusta, Aurélie, Brayer, Kathryn, Plaza, Silvia L., Mazur, Erik C., Emera, Deena, Sheikh, Shehzad Z., Grützner, Frank, Bauersachs, Stefan, Graf, Alexander, Young, Steven L., Lieb, Jason D., DeMayo, Francesco J., Feschotte, Cédric, Wagner, Günter P.

“…A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters…”
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Antiproliferative Action of Progesterone in Uterine Epithelium Is Mediated by Hand2 by Li, Quanxi, Kannan, Athilakshmi, DeMayo, Francesco J, Lydon, John P, Cooke, Paul S, Yamagishi, Hiroyuki, Srivastava, Deepak, Bagchi, Milan K, Bagchi, Indrani C

“…During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear. The attenuation…”
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BMPR2 is required for postimplantation uterine function and pregnancy maintenance by Nagashima, Takashi, Li, Qinglei, Clementi, Caterina, Lydon, John P, DeMayo, Francesco J, Matzuk, Martin M

“…Abnormalities in cell-cell communication and growth factor signaling pathways can lead to defects in maternal-fetal interactions during pregnancy, including…”
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SOX17 regulates uterine epithelial–stromal cross-talk acting via a distal enhancer upstream of Ihh by Wang, Xiaoqiu, Li, Xilong, Wang, Tianyuan, Wu, San-Pin, Jeong, Jae-Wook, Kim, Tae Hoon, Young, Steven L., Lessey, Bruce A., Lanz, Rainer B., Lydon, John P., DeMayo, Francesco J.

“…Mammalian pregnancy depends on the ability of the uterus to support embryo implantation. Previous studies reveal the Sox17 gene as a downstream target of the…”
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Progesterone Receptor Transcriptome and Cistrome in Decidualized Human Endometrial Stromal Cells by Mazur, Erik C, Vasquez, Yasmin M, Li, Xilong, Kommagani, Ramakrishna, Jiang, Lichun, Chen, Rui, Lanz, Rainer B, Kovanci, Ertug, Gibbons, William E, DeMayo, Francesco J

“…Decidualization is a complex process involving cellular proliferation and differentiation of the endometrial stroma that is required to establish and support…”
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Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor by Hai, Lan, Maurya, Vineet K, DeMayo, Francesco J, Lydon, John P

“…Using an established human primary cell culture model, we previously demonstrated that the promyelocytic leukemia zinc finger (PLZF) transcription factor is a…”
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TRIM28 modulates nuclear receptor signaling to regulate uterine function by Li, Rong, Wang, Tianyuan, Marquardt, Ryan M., Lydon, John P., Wu, San-Pin, DeMayo, Francesco J.

“…Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate…”
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FOXO1 is Required for Binding of PR on IRF4, Novel Transcriptional Regulator of Endometrial Stromal Decidualization by Vasquez, Yasmin M, Mazur, Erik C, Li, Xilong, Kommagani, Ramakrishna, Jiang, Lichun, Chen, Rui, Lanz, Rainer B, Kovanci, Ertug, Gibbons, William E, DeMayo, Francesco J

“…The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs)…”
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Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment by Wetendorf, Margeaux, Wu, San-Pin, Wang, Xiaoqiu, Creighton, Chad J, Wang, Tianyuan, Lanz, Rainer B, Blok, Leen, Tsai, Sophia Y, Tsai, Ming-Jer, Lydon, John P, DeMayo, Francesco J

“…The precise timing of progesterone signaling through its cognate receptor, the progesterone receptor (PGR), is critical for the establishment and maintenance…”
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Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis by Monsivais, Diana, Nagashima, Takashi, Prunskaite-Hyyryläinen, Renata, Nozawa, Kaori, Shimada, Keisuke, Tang, Suni, Hamor, Clark, Agno, Julio E., Chen, Fengju, Masand, Ramya P., Young, Steven L., Creighton, Chad J., DeMayo, Francesco J., Ikawa, Masahito, Lee, Se-Jin, Matzuk, Martin M.

“…During early pregnancy in the mouse, nidatory estrogen (E2) stimulates endometrial receptivity by activating a network of signaling pathways that is not yet…”
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A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function by Rubel, Cory A., Wu, San-Pin, Lin, Lin, Wang, Tianyuan, Lanz, Rainer B., Li, Xilong, Kommagani, Ramakrishna, Franco, Heather L., Camper, Sally A., Tong, Qiang, Jeong, Jae-Wook, Lydon, John P., DeMayo, Francesco J.

“…Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of…”
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The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization by Kommagani, Ramakrishna, Szwarc, Maria M, Vasquez, Yasmin M, Peavey, Mary C, Mazur, Erik C, Gibbons, William E, Lanz, Rainer B, DeMayo, Francesco J, Lydon, John P

“…Progesterone, via the progesterone receptor (PGR), is essential for endometrial stromal cell decidualization, a cellular transformation event in which stromal…”
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