Search Results - "DeLucia, Angela M."

Mechanisms Decreasing In Vitro Susceptibility to the LpxC Inhibitor CHIR-090 in the Gram-Negative Pathogen Pseudomonas aeruginosa by CAUGHLAN, Ruth E, JONES, Adriana K, DEAN, Charles R, DELUCIA, Angela M, WOODS, Angela L, LILI XIE, BING MA, BARNES, S. Whitney, WALKER, John R, SPRAGUE, Elizabeth R, XIA YANG

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Lipopolysaccharide (LPS) inner-core phosphates are required for complete LPS synthesis and transport to the outer membrane in Pseudomonas aeruginosa PAO1 by Delucia, Angela M, Six, David A, Caughlan, Ruth E, Gee, Patricia, Hunt, Ian, Lam, Joseph S, Dean, Charles R

“…Gram-negative outer membrane (OM) integrity is maintained in part by Mg(2+) cross-links between phosphates on lipid A and on core sugars of adjacent…”
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The Properties of Steric Gate Mutants Reveal Different Constraints within the Active Sites of Y-family and A-family DNA Polymerases by DeLucia, Angela M., Chaudhuri, Santanov, Potapova, Olga, Grindley, Nigel D.F., Joyce, Catherine M.

“…Y-family (lesion-bypass) DNA polymerases show the same overall structural features seen in other members of the polymerase superfamily, yet their active sites…”
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Fingers-Closing and Other Rapid Conformational Changes in DNA Polymerase I (Klenow Fragment) and Their Role in Nucleotide Selectivity by Joyce, Catherine M, Potapova, Olga, DeLucia, Angela M, Huang, Xuanwei, Basu, Vandana Purohit, Grindley, Nigel D. F

“…We have developed a FRET-based assay for the fingers-closing conformational transition that occurs when a binary complex of DNA polymerase I (Klenow fragment)…”
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UmuD2 Inhibits a Non-covalent Step during DinB-mediated Template Slippage on Homopolymeric Nucleotide Runs by Foti, James J., DeLucia, Angela M., Joyce, Catherine M., Walker, Graham C.

“…Escherichia coli DinB (DNA polymerase IV) possesses an enzyme architecture resulting in specialized lesion bypass function and the potential for creating −1…”
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UmuD(2) inhibits a non-covalent step during DinB-mediated template slippage on homopolymeric nucleotide runs by Foti, James J, Delucia, Angela M, Joyce, Catherine M, Walker, Graham C

“…Escherichia coli DinB (DNA polymerase IV) possesses an enzyme architecture resulting in specialized lesion bypass function and the potential for creating -1…”
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Conformational Changes during Normal and Error-Prone Incorporation of Nucleotides by a Y-Family DNA Polymerase Detected by 2-Aminopurine Fluorescence by DeLucia, Angela M, Grindley, Nigel D. F, Joyce, Catherine M

“…Y-family polymerases are specialized to carry out DNA synthesis past sites of DNA damage. Their active sites make fewer contacts to their substrates,…”
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An error‐prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a ‘steric gate’ residue for discrimination against ribonucleotides by DeLucia, Angela M., Grindley, Nigel D. F., Joyce, Catherine M.

“…DNA polymerases of the A and B families, and reverse transcriptases, share a common mechanism for preventing incorporation of ribonucleotides: a highly…”
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DNA Polymerase Catalysis in the Absence of Watson−Crick Hydrogen Bonds:  Analysis by Single-Turnover Kinetics by Potapova, Olga, Chan, Chikio, DeLucia, Angela M, Helquist, Sandra A, Kool, Eric T, Grindley, Nigel D. F, Joyce, Catherine M

“…We report the first pre-steady-state kinetic studies of DNA replication in the absence of hydrogen bonds. We have used nonpolar nucleotide analogues that mimic…”
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