Search Results - "DeLuca, Keith F."

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells by Broad, Amanda J, DeLuca, Keith F, DeLuca, Jennifer G

“…Aurora B kinase has a critical role in regulating attachments between kinetochores and spindle microtubules during mitosis. Early in mitosis, kinase activity…”
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Real-time quantification of single RNA translation dynamics in living cells by Morisaki, Tatsuya, Lyon, Kenneth, DeLuca, Keith F., DeLuca, Jennifer G., English, Brian P., Zhang, Zhengjian, Lavis, Luke D., Grimm, Jonathan B., Viswanathan, Sarada, Looger, Loren L., Lionnet, Timothee, Stasevich, Timothy J.

“…Although messenger RNA (mRNA) translation is a fundamental biological process, it has never been imaged in real time in vivo with single-molecule precision. To…”
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Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis by DeLuca, Keith F, Lens, Susanne M A, DeLuca, Jennifer G

“…Precise control of the attachment strength between kinetochores and spindle microtubules is essential to preserve genomic stability. Aurora B kinase has been…”
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Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics by DeLuca, Keith F, Meppelink, Amanda, Broad, Amanda J, Mick, Jeanne E, Peersen, Olve B, Pektas, Sibel, Lens, Susanne M A, DeLuca, Jennifer G

“…Precise regulation of kinetochore-microtubule attachments is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase,…”
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KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity by Caldas, Gina V, DeLuca, Keith F, DeLuca, Jennifer G

“…Aurora B kinase phosphorylates kinetochore proteins during early mitosis, increasing kinetochore–microtubule (MT) turnover and preventing premature…”
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Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions by Zaytsev, Anatoly V, Sundin, Lynsie J R, DeLuca, Keith F, Grishchuk, Ekaterina L, DeLuca, Jennifer G

“…Accurate chromosome segregation relies on dynamic interactions between microtubules (MTs) and the NDC80 complex, a major kinetochore MT-binding component…”
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Production and purification of recombinant monoclonal antibodies from human cells based on a primary sequence by DeLuca, Keith F., Mick, Jeanne E., DeLuca, Jennifer G.

“…There are challenges to using commercially available antibodies generated in animals, including concerns with reproducibility, high costs, and ethical issues…”
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Generation and diversification of recombinant monoclonal antibodies by DeLuca, Keith F, Mick, Jeanne E, Ide, Amy H, Lima, Wanessa C, Sherman, Lori, Schaller, Kristin L, Anderson, Steven M, Zhao, Ning, Stasevich, Timothy J, Varma, Dileep, Nilsson, Jakob, DeLuca, Jennifer G

“…Antibodies are indispensable tools used for a large number of applications in both foundational and translational bioscience research; however, there are…”
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The role of kinetochore dynein in checkpoint silencing is restricted to disassembly of the corona by Ide, Amy H, DeLuca, Keith F, Wiggan, O'Neil, Markus, Steven M, DeLuca, Jennifer G

“…During mitosis, kinetochore-microtubule attachments are monitored by a molecular surveillance system known as the spindle assembly checkpoint. The prevailing…”
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Superresolved multiphoton microscopy with spatial frequency-modulated imaging by Field, Jeffrey J., Wernsing, Keith A., Domingue, Scott R., Motz, Alyssa M. Allende, DeLuca, Keith F., Levi, Dean H., DeLuca, Jennifer G., Young, Michael D., Squier, Jeff A., Bartels, Randy A.

“…Superresolved far-field microscopy has emerged as a powerful tool for investigating the structure of objects with resolution well below the diffraction limit…”
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Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities by Herman, Jacob A, Romain, Romario R, Hoellerbauer, Pia, Shirnekhi, Hazheen K, King, David C, DeLuca, Keith F, Osborne Nishimura, Erin, Paddison, Patrick J, DeLuca, Jennifer G

“…Aneuploidy, the incorrect number of whole chromosomes, is a common feature of tumors that contributes to their initiation and evolution. Preventing aneuploidy…”
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The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore-microtubule attachment formation and Ska complex recruitment by Wimbish, Robert T, DeLuca, Keith F, Mick, Jeanne E, Himes, Jack, Jiménez-Sánchez, Ignacio, Jeyaprakash, A Arockia, DeLuca, Jennifer G

“…The conserved kinetochore-associated NDC80 complex (composed of Hec1/Ndc80, Nuf2, Spc24, and Spc25) has well-documented roles in mitosis including 1)…”
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Measuring Kinetochore-Microtubule Attachment Stability in Cultured Cells by DeLuca, Keith F, Herman, Jacob A, DeLuca, Jennifer G

“…Duplicated sister chromatids connect to the mitotic spindle through kinetochores, large proteinaceous structures built at sites of centromeric heterochromatin…”
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Cytoskeletal alterations associated with donor age and culture interval for equine oocytes and potential zygotes that failed to cleave after intracytoplasmic sperm injection by Ruggeri, Elena, DeLuca, Keith F, Galli, Cesare, Lazzari, Giovanna, DeLuca, Jennifer G, Carnevale, Elaine M

“…Intracytoplasmic sperm injection (ICSI) is an established method to fertilise equine oocytes, but not all oocytes cleave after ICSI. The aims of the present…”
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Incremental Phosphorylation of a Dynamic Lawn of NDC80 Complexes Provides Graded Control of Kinetochore-Microtubule Affinity by Zaytsev, Anatoly, Sundin, Lynsie J.R., Nikashin, Boris, DeLuca, Keith F., Mick, Jeanne, Guimaraes, Geoffrey J., Ataullakhanov, Fazly I., Grishchuk, Ekaterina L., DeLuca, Jennifer G.

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Super-resolved multimodal multiphoton microscopy with spatial frequency-modulated imaging by Field, Jeffrey J, Wernsing, Keith W, Domingue, Scott R, Motz, Alyssa M. Allende, DeLuca, Keith F, DeLuca, Jennifer G, Kuciauskas, Darius, Levi, Dean H, Squier, Jeff A, Bartels, Randy A

“…Super-resolved far-field microscopy has emerged as a powerful tool for investigating the structure of objects with resolution well below the diffraction limit…”
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