Search Results - "DeLuca, Jesse"
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Hemoperfusion with Seraph 100 Microbind Affinity Blood Filter Unlikely to Require Increased Antibiotic Dosing: A Simulations Study Using a Pharmacokinetic/Pharmacodynamic Approach
Published in Blood purification (2023)“…The Seraph® 100 Microbind® Affinity Blood Filter (Seraph 100) is a hemoperfusion device that can remove pathogens from central circulation. However, the effect…”
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Pharmacokinetics, safety and efficacy of intra‐articular non‐steroidal anti‐inflammatory drug injections for the treatment of osteoarthritis: A narrative review
Published in Journal of clinical pharmacy and therapeutics (01-08-2022)“…What is known and Objective Osteoarthritis (OA) is a common cause of joint disease and activity limitation in adults. Common therapies to treat OA‐related pain…”
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Impact of Blast Overpressure on the Pharmacokinetics of Various Antibiotics in Sprague Dawley Rats
Published in Military medicine (08-11-2023)“…ABSTRACT Introduction Combat injuries are complex and multimodal. Most injuries to the extremities occur because of explosive devices such as improvised…”
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Semimechanistic Modeling of the Effects of Blast Overpressure Exposure on Cefazolin Pharmacokinetics in Mice
Published in The Journal of pharmacology and experimental therapeutics (01-11-2021)“…Cefazolin is a first-line antibiotic to treat infection related to deployment-associated blast injuries. Prior literature demonstrated a 331% increase…”
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Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users
Published in Journal of xenobiotics (10-05-2023)“…Selective Androgen Receptor Modulators (SARMs) are not FDA approved, and obtaining SARMs for personal use is illegal. Nevertheless, SARM use is increasingly…”
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Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini‐review and population pharmacokinetic analysis
Published in Journal of clinical pharmacy and therapeutics (01-08-2022)“…What is known and objective Timely and appropriate dosing of antibiotics is essential for the treatment of bacterial sepsis. Critically ill patients treated…”
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Evaluation of Pharmacogenomics Testing of Cytochrome P450 Enzymes in the Military Health System From 2015 to 2020
Published in Military medicine (30-12-2021)“…ABSTRACT Pharmacogenomics (PGx) plays a fundamental role in personalized medicine, providing an evidence-based treatment approach centered on the relationship…”
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Systematic Review and Meta-Analysis of the Effect of Loop Diuretics on Antibiotic Pharmacokinetics
Published in Pharmaceutics (05-05-2023)“…Loop diuretics and antibiotics are commonly co-prescribed across many clinical care settings. Loop diuretics may alter antibiotic pharmacokinetics (PK) via…”
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Daily Naltrexone Use Does Not Adversely Affect Physical, Cognitive or Marksmanship Performance in U.S. Army Soldiers
Published in Military medicine (27-02-2024)“…ABSTRACT Introduction Considering the potential of weaponized opioids, evaluating how prophylactic countermeasures affect military-relevant performance is…”
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Plerixafor for pathogen‐agnostic treatment in murine thigh infection and zebrafish sepsis
Published in Clinical and translational science (01-07-2024)“…Plerixafor is a CXCR4 antagonist approved in 2008 by the FDA for hematopoietic stem cell collection. Subsequently, plerixafor has shown promise as a potential…”
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Applying Pharmacogenomic Guidelines to Combat Medical Care
Published in Military medicine (01-01-2022)“…ABSTRACT Pharmacogenomics is a pillar of personalized medicine that has the potential to deliver optimized treatment in many medical settings. Military…”
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Beta-Lactam Probability of Target Attainment Success: Cefepime as a Case Study
Published in Antibiotics (Basel) (23-02-2023)“…Probability of target attainment (PTA) analysis using Monte Carlo simulations has become a mainstay of dose optimization. We highlight the technical and…”
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Prescription Patterns and Relationship to Pharmacogenomics Testing in the Military Health System
Published in Military medicine (01-01-2022)“…ABSTRACT Introduction Clinical utilization of pharmacogenomics (PGx) testing is highly institutionally dependent, and little information is known about…”
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Toward Personalized Medicine Implementation: Survey of Military Medicine Providers in the Area of Pharmacogenomics
Published in Military medicine (02-03-2020)“…Abstract Introduction Personalized medicine is the right treatment, to the right patient, at the right dose. Knowledge of genetic predisposition to variable…”
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Risk of type 2 diabetes mellitus by antimuscarinic agents among adult females receiving care in the military health system
Published in Pharmacoepidemiology and drug safety (01-12-2020)“…Purpose To explore patterns of antimuscarinic medication as a risk factor for type 2 diabetes mellitus (T2DM). Methods This is a retrospective cohort study of…”
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Comparison of Piperacillin and Tazobactam Pharmacokinetics in Critically Ill Patients with Trauma or with Burn
Published in Antibiotics (Basel) (04-05-2022)“…Critical illness caused by burn and sepsis is associated with pathophysiologic changes that may result in the alteration of pharmacokinetics (PK) of…”
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An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model
Published in Malaria journal (16-09-2020)“…Malaria remains the top infectious disease threat facing the U.S. military in many forward operating environments. Compliance with malaria chemoprophylaxis…”
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Technical Innovation Case Report: Ultrasound-Guided Prolotherapy Injection for Insertional Achilles Calcific Tendinosis
Published in Case reports in orthopedics (01-01-2016)“…We describe the use of ultrasound guidance for hyperosmolar dextrose (prolotherapy) injection of the distal calcaneal tendon specifically just anterior to…”
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Kinematic Modeling and L1 Adaptive Position Control of a 6 Degree of Freedom Robot Arm
Published 01-01-2021“…In recent decades robots have become more commonly used in industrial settings and in everyday life. As they become more common, they are being used to solve…”
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Dissertation -
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Treatment of Acute Carpal Bone Fractures
Published in Current sports medicine reports (01-09-2017)“…Carpal bone fractures are common hand fractures that can be complicated by concomitant damage to surrounding structures, chronic comorbidities, or delays in…”
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