Search Results - "DeLong, Mahlon R"

Basal Ganglia Circuits as Targets for Neuromodulation in Parkinson Disease by DeLong, Mahlon R, Wichmann, Thomas

“…The revival of stereotactic surgery for Parkinson disease (PD) in the 1990s, with pallidotomy and then with high-frequency deep brain stimulation (DBS), has…”
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Deep Brain Stimulation for Movement Disorders of Basal Ganglia Origin: Restoring Function or Functionality? by Wichmann, Thomas, DeLong, Mahlon R.

“…Deep brain stimulation (DBS) is highly effective for both hypo- and hyperkinetic movement disorders of basal ganglia origin. The clinical use of DBS is, in…”
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Phenomenology and classification of dystonia: A consensus update by Albanese, Alberto, Bhatia, Kailash, Bressman, Susan B., DeLong, Mahlon R., Fahn, Stanley, Fung, Victor S.C., Hallett, Mark, Jankovic, Joseph, Jinnah, Hyder A., Klein, Christine, Lang, Anthony E., Mink, Jonathan W., Teller, Jan K.

“…ABSTRACT This report describes the consensus outcome of an international panel consisting of investigators with years of experience in this field that reviewed…”
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Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease by Redgrave, Peter, Obeso, Jose A, Rodriguez, Manuel, Smith, Yoland, Rodriguez-Oroz, Maria C, Lehericy, Stephane, Bergman, Hagai, Agid, Yves, DeLong, Mahlon R

“…Key Points The basal ganglia are one of the fundamental processing units of the mammalian brain. Progressive degeneration of one of their major components, the…”
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Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa by SMITH, Yoland, WICHMANN, Thomas, FACTOR, Stewart A, DELONG, Mahlon R

“…The demonstration that dopamine loss is the key pathological feature of Parkinson's disease (PD), and the subsequent introduction of levodopa have…”
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Deep Brain Stimulation for Neurologic and Neuropsychiatric Disorders by Wichmann, Thomas, DeLong, Mahlon R.

“…In the 1960s, ablative stereotactic surgery was employed for a variety of movement disorders and psychiatric conditions. Although largely abandoned in the…”
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Primary motor cortex of the parkinsonian monkey: altered encoding of active movement by Pasquereau, Benjamin, DeLong, Mahlon R, Turner, Robert S

“…Abnormalities in the movement-related activation of the primary motor cortex (M1) are thought to be a major contributor to the motor signs of Parkinson's…”
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Milestones in research on the pathophysiology of Parkinson's disease by Wichmann, Thomas, DeLong, Mahlon R., Guridi, Jorge, Obeso, Jose A.

“…Progress in our understanding of the mechanisms underlying the cardinal motor abnormalities of Parkinson's disease (PD), in particular akinesia and…”
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The focal dystonias: Current views and challenges for future research by Jinnah, H. A., Berardelli, Alfredo, Comella, Cynthia, DeFazio, Giovanni, DeLong, Mahlon R., Factor, Stewart, Galpern, Wendy R., Hallett, Mark, Ludlow, Christy L., Perlmutter, Joel S., Rosen, Ami R.

“…ABSTRACT The most common forms of dystonia are those that develop in adults and affect a relatively isolated region of the body. Although these adult‐onset…”
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Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease by Singh, Arun, Mewes, Klaus, Gross, Robert E., DeLong, Mahlon R., Obeso, José A., Papa, Stella M.

“…Circuitry models of Parkinson’s disease (PD) are based on striatal dopamine loss and aberrant striatal inputs into the basal ganglia network. However,…”
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Mood Disorders in the Medically Ill: Scientific Review and Recommendations by Evans, Dwight L., Charney, Dennis S., Lewis, Lydia, Golden, Robert N., Gorman, Jack M., Krishnan, K. Ranga Rama, Nemeroff, Charles B., Bremner, J. Douglas, Carney, Robert M., Coyne, James C., Delong, Mahlon R., Frasure-Smith, Nancy, Glassman, Alexander H., Gold, Philip W., Grant, Igor, Gwyther, Lisa, Ironson, Gail, Johnson, Robert L., Kanner, Andres M., Katon, Wayne J., Kaufmann, Peter G., Keefe, Francis J., Ketter, Terence, Laughren, Thomas P., Leserman, Jane, Lyketsos, Constantine G., McDonald, William M., McEwen, Bruce S., Miller, Andrew H., Musselman, Dominique, O’Connor, Christopher, Petitto, John M., Pollock, Bruce G., Robinson, Robert G., Roose, Steven P., Rowland, Julia, Sheline, Yvette, Sheps, David S., Simon, Gregory, Spiegel, David, Stunkard, Albert, Sunderland, Trey, Tibbits, Paul, Valvo, William J.

“…The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected…”
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Inversion of Dopamine Responses in Striatal Medium Spiny Neurons and Involuntary Movements by Liang, Li, DeLong, Mahlon R, Papa, Stella M

“…Dopamine influence in the striatum is essential to motor behavior and may lead to involuntary movements in pathologic conditions. The basic mechanisms lie in…”
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Circuits and circuit disorders of the basal ganglia by DeLong, Mahlon R, Wichmann, Thomas

“…Views of the anatomy and function of the basal ganglia and their role in motor and nonmotor disorders have undergone major revisions during the past decades…”
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Patient selection and assessment recommendations for deep brain stimulation in Tourette syndrome by Mink, Jonathan W., Walkup, John, Frey, Kirk A., Como, Peter, Cath, Danielle, DeLong, Mahlon R., Erenberg, Gerald, Jankovic, Joseph, Juncos, Jorge, Leckman, James F., Swerdlow, Neal, Visser-Vandewalle, Veerle, Vitek, Jerrold L.

“…In response to recent publicity regarding the potential use of deep brain stimulation (DBS) for reducing tic severity in Tourette's syndrome (TS), the Tourette…”
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Intraoperative neurophysiology in DBS for dystonia by Vitek, Jerry L., DeLong, Mahlon R., Starr, Philip A., Hariz, Marwan I., Metman, Leo Verhagen

“…Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) has been demonstrated to be an effective therapy for the treatment of primary…”
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Functional and pathophysiological models of the basal ganglia by Wichmann, Thomas, DeLong, Mahlon R

“…Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases)…”
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Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research by Wichmann, Thomas, Bergman, Hagai, DeLong, Mahlon R.

“…Studies in non-human primates (NHPs) have led to major advances in our understanding of the function of the basal ganglia and of the pathophysiologic…”
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Temporal profile of improvement of tardive dystonia after globus pallidus deep brain stimulation by Shaikh, Aasef G, Mewes, Klaus, DeLong, Mahlon R, Gross, Robert E, Triche, Shirley D, Jinnah, H.A, Boulis, Nicholas, Willie, Jon T, Freeman, Alan, Alexander, Garrett E, Aia, Pratibha, Butefisch, Cathrine M, Esper, Christine D, Factor, Stewart A

“…Abstract Background Several case reports and small series have indicated that tardive dystonia is responsive to globus pallidus deep brain stimulation. Whether…”
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Somatotopic organization in the internal segment of the globus pallidus in Parkinson's disease by Baker, Kenneth B., Lee, John Y.K., Mavinkurve, Gaurav, Russo, Gary S., Walter, Benjamin, DeLong, Mahlon R., Bakay, Roy A.E., Vitek, Jerrold L.

“…Ablation or deep brain stimulation in the internal segment of the globus pallidus (GPi) is an effective therapy for the treatment of Parkinson's disease (PD)…”
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Randomized trial of pallidotomy versus medical therapy for Parkinson's disease by Vitek, Jerrold L., Bakay, Roy A. E., Freeman, Alan, Evatt, Marian, Green, Joanne, McDonald, William, Haber, Michael, Barnhart, Huiman, Wahlay, Natalie, Triche, Shirley, Mewes, Klaus, Chockkan, Vijay, Zhang, Jian-Yu, DeLong, Mahlon R.

“…Thirty‐six patients with Parkinson's disease (PD) were randomized to either medical therapy (N = 18) or unilateral GPi pallidotomy (N = 18). The primary…”
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