Search Results - "DeLisle, Robert K."

Impact of Kidney Function on the Blood Proteome and on Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease by Yang, Joseph, Brody, Edward N, Murthy, Ashwin C, Mehler, Robert E, Weiss, Sophie J, DeLisle, Robert K, Ostroff, Rachel, Williams, Stephen A, Ganz, Peter

“…Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological…”
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Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection by Hanson, Barbara A., Visvabharathy, Lavanya, Orban, Zachary S., Jimenez, Millenia, Batra, Ayush, Liotta, Eric M., DeLisle, Robert K., Klausner, Jeffrey D., Cohen, Pinchas, Padhye, Advait S., Tachas, George, Koralnik, Igor J.

“…•Neuro-PASC patients show plasma proteomic alterations 3–9 months post infection.•Plasma proteome differences are identified based on PASC symptoms.•Proteomic…”
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Improving Assessment of Drug Safety Through Proteomics: Early Detection and Mechanistic Characterization of the Unforeseen Harmful Effects of Torcetrapib by Williams, Stephen A, Murthy, Ashwin C, DeLisle, Robert K, Hyde, Craig, Malarstig, Anders, Ostroff, Rachel, Weiss, Sophie J, Segal, Mark R, Ganz, Peter

“…BACKGROUND:Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug…”
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The Impact of the Glomerular Filtration Rate on the Human Plasma Proteome by Christensson, Anders, Ash, Jessica A., DeLisle, Robert K., Gaspar, Fraser W., Ostroff, Rachel, Grubb, Anders, Lindström, Veronica, Bruun, Laila, Williams, Steve A.

“…Purpose The application of proteomics in chronic kidney disease (CKD) can potentially uncover biomarkers and pathways that are predictive of disease…”
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EARLY DETECTION OF THE UNEXPECTED, HARMFUL, PHARMACOLOGIC EFFECTS OF TORCETRAPIB: A RETROSPECTIVE PROTEOMICS ANALYSIS OF PLASMA SAMPLES FROM THE ILLUMINATE TRIAL by Williams, Stephen, DeLisle, Robert K, Hyde, Craig L, Malarstig, Anders, Ostroff, Rachel, Weiss, Sophie

“…Background: Early detection of adverse effects of novel therapies and their mechanistic understanding prior to large-scale clinical trials could prevent harm…”
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Elucidation of the Na +, K +-ATPase digitalis binding site by Keenan, Susan M., DeLisle, Robert K., Welsh, William J., Paula, Stefan, Ball, William J.

“…Despite controversy over their use and the potential for toxic side effects, cardiac glycosides have remained an important clinical component for the treatment…”
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Spirocyclic β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (CSF) Amyloid β in a Higher Species by Hunt, Kevin W, Cook, Adam W, Watts, Ryan J, Clark, Christopher T, Vigers, Guy, Smith, Darin, Metcalf, Andrew T, Gunawardana, Indrani W, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Thomas, Allen A, Rana, Sumeet, Kallan, Nicholas C, DeLisle, Robert K, Rizzi, James P, Regal, Kelly, Sammond, Douglas, Groneberg, Robert, Siu, Michael, Purkey, Hans, Lyssikatos, Joseph P, Marlow, Allison, Liu, Xingrong, Tang, Tony P

“…A hallmark of Alzheimer’s disease is the brain deposition of amyloid beta (Aβ), a peptide of 36–43 amino acids that is likely a primary driver of…”
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Discovery of 7‑Tetrahydropyran-2-yl Chromans: β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β‑Protein (Aβ) in the Central Nervous System by Thomas, Allen A, Hunt, Kevin W, Volgraf, Matthew, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Sammond, Douglas, Tang, Tony P, Rhodes, Susan P, Metcalf, Andrew T, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Do, Mary K. Geck, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P, Gunawardana, Indrani W

“…In an attempt to increase selectivity vs Cathepsin D (CatD) in our BACE1 program, a series of 1,3,4,4a,10,10a-hexahydropyrano[4,3-b]chromene analogues was…”
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8‑Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors by Thomas, Allen A, Hunt, Kevin W, Newhouse, Brad, Watts, Ryan J, Liu, Xingrong, Vigers, Guy, Smith, Darin, Rhodes, Susan P, Brown, Karin D, Otten, Jennifer N, Burkard, Michael, Cox, April A, Geck Do, Mary K, Dutcher, Darrin, Rana, Sumeet, DeLisle, Robert K, Regal, Kelly, Wright, Albion D, Groneberg, Robert, Liao, Jiangpeng, Scearce-Levie, Kimberly, Siu, Michael, Purkey, Hans E, Lyssikatos, Joseph P

“…A series of 2,3,4,4a,10,10a-hexahydropyrano[3,2-b]chromene analogs was developed that demonstrated high selectivity (>2000-fold) for BACE1 vs Cathepsin D…”
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Technique for Generating Three-Dimensional Alignments of Multiple Ligands from One-Dimensional Alignments by Anghelescu, Andrei V, DeLisle, Robert K, Lowrie, Jeffrey F, Klon, Anthony E, Xie, Xiaoming, Diller, David J

“…We describe and demonstrate a method for the simultaneous, fully flexible alignment of multiple molecules with a common biological activity. The key aspect of…”
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Fast Small Molecule Similarity Searching with Multiple Alignment Profiles of Molecules Represented in One-Dimension by Wang, Norman, DeLisle, Robert K, Diller, David J

“…Multiple sequence alignment has proven to be a powerful method for creating protein and DNA sequence alignment profiles. These profiles of protein families are…”
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Interaction of Organophosphate Pesticides and Related Compounds with the Androgen Receptor by Tamura, Hiroto, Yoshikawa, Hiromichi, Gaido, Kevin W., Ross, Susan M., DeLisle, Robert K., Welsh, William J., Richard, Ann M.

“…Identification of several environmental chemicals capable of binding to the androgen receptor (AR) and interfering with its normal function has heightened…”
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The Vitamin D Receptor Interacts with General Transcription Factor IIB (∗) by MacDonald, Paul N., Sherman, David R., Dowd, Diane R., Jefcoat, Stephen C., DeLisle, Robert K.

“…The vitamin D receptor (VDR) heterodimerizes with retinoid X receptors (RXR) on many vitamin D-responsive promoter elements, suggesting that this complex is…”
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Computational Models for Predicting the Binding Affinities of Ligands for the Wild-Type Androgen Receptor and a Mutated Variant Associated with Human Prostate Cancer by Ai, Ni, DeLisle, Robert K, Yu, Seong Jae, Welsh, William J

“…In the present study, values of the binding energy (BE) were calculated for the rat androgen receptor on a data set of 25 steroidal and nonsteroidal compounds…”
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The Autonomous Transactivation Domain in Helix H3 of the Vitamin D Receptor Is Required For Transactivation and Coactivator Interaction by Kraichely, Dennis M., Collins, John J., DeLisle, Robert K., MacDonald, Paul N.

“…A ligand-inducible transactivation function (AF-2) exists in the extreme carboxyl terminus of the vitamin D receptor (VDR) that is essential for…”
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Three-Dimensional Structure-Activity Relationship Modeling of Digoxin Inhibition and Docking to Na+,K+-ATPase by BALL JR, W. JAMES, FARR, CAROL D., PAULA, STEFAN, KEENAN, SUSAN M., DELISLE, ROBERT K., WELSH, WILLIAM J.

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Trauma-induced neurotoxicity in rat hippocampal neurons by Yoon, K W, Mitchell, H L, Broder, L D, Brooker, R W, Delisle, R K

“…We have previously shown that traumatic injury of hippocampal cells triggers release of a soluble neurotoxin that can be transferred to an uninjured culture…”
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Abstract 551: A potent and selective cFMS inhibitor regulates the tumor macrophage microenvironment leading to tumor growth inhibition by Wright, Albion D., Willis, Brandon S., Gomez, Anna, Boys, Mark L., DeLisle, Robert K., Burgess, Laurence E., Munson, Mark C., Kennedy, April L., Topalov, George T., Zhao, Qian, Rodriguez, Martha E., Rast, Bryson, Rizzi, James P., DeWolf, Walter E., Lemieux, Christine, Anderson, Deborah, Neale, Jason R., Martinson, Matthew, Gross, Stefan D., Callejo, Michele, Risom, Tyler, Lee, Patrice A.

“…Abstract Increasing evidence suggests that interactions between tumor cells, stromal cells, macrophages and the extracellular matrix are pivotal to the…”
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Abstract 14408: The Impact of Kidney Function on the Blood Proteome and Protein Cardiovascular Risk Biomarkers in Patients With Stable Coronary Heart Disease by Yang, Joseph, Brody, Edward N, Mehler, Robert E, Weiss, Sophie J, DeLisle, Robert K, Ostroff, Rachel, Williams, Stephen A, Ganz, Peter

“…IntroductionChronic kidney disease (CKD) confers increased risk of cardiovascular (CV) events. Traditional risk factors, such as hypertension and diabetes…”
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Abstract 17082: Translation From Highly Multiplexed Biomarker Discovery to a Targeted Protein Panel to Stratify Cardiovascular Risk in Patients With Coronary Heart Disease by DeLisle, Robert K, Ganz, Peter, Katilius, Evaldas, Kato, Shintaro, Ostroff, Rachel, Sterling, David, Williams, Stephen

“…IntroductionFailure to translate biomarkers from research publication to practical clinical measurements is well-recognized. The objective of this study was to…”
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