Search Results - "DeLeeuw, Lynn W"

Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Monsen, Robert C, Maguire, Jon M, DeLeeuw, Lynn W, Chaires, Jonathan B, Trent, John O

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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Human POT1 unfolds G-quadruplexes by conformational selection by Chaires, Jonathan B, Gray, Robert D, Dean, William L, Monsen, Robert, DeLeeuw, Lynn W, Stribinskis, Vilius, Trent, John O

“…Abstract The reaction mechanism by which the shelterin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully…”
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Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences by Monsen, Robert C, DeLeeuw, Lynn W, Dean, William L, Gray, Robert D, Chakravarthy, Srinivas, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Abstract We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach…”
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Structural characterization and targeting of higher-order promoter G-quadruplexes by Monsen, Robert C., DeLeeuw, Lynn W., Dean, William L., Gray, Robert D., Chakravarthy, Srinivas, Hopkins, Jesse B., Chaires, Jonathan B., Trent, John O.

“…Abstract only…”
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Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Robert C Monsen, Jon M Maguire, Lynn W DeLeeuw, Jonathan B Chaires, John O Trent

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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Thermodynamics and specificity of the yeast transcription factor Mbp1-DNA interaction by DeLeeuw, Lynn W

“…Mbp1, (Mlu-1 box Binding Protein) a transcription factor from the budding yeast, Saccharomyces cerevisiae, plays a key role in the G1/S transition in the cell…”
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