Search Results - "DeLeeuw, Lynn"

Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Monsen, Robert C, Maguire, Jon M, DeLeeuw, Lynn W, Chaires, Jonathan B, Trent, John O

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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The hTERT core promoter forms three parallel G-quadruplexes by Monsen, Robert C, DeLeeuw, Lynn, Dean, William L, Gray, Robert D, Sabo, T Michael, Chakravarthy, Srinivas, Chaires, Jonathan B, Trent, John O

“…The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter is disputed. One model features a structure with three…”
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Human POT1 unfolds G-quadruplexes by conformational selection by Chaires, Jonathan B, Gray, Robert D, Dean, William L, Monsen, Robert, DeLeeuw, Lynn W, Stribinskis, Vilius, Trent, John O

“…Abstract The reaction mechanism by which the shelterin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully…”
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Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences by Monsen, Robert C, DeLeeuw, Lynn W, Dean, William L, Gray, Robert D, Chakravarthy, Srinivas, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Abstract We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach…”
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Activation of the Proapoptotic Bcl-2 Protein Bax by a Small Molecule Induces Tumor Cell Apoptosis by Zhao, Guoping, Zhu, Yanglong, Eno, Colins O., Liu, Yanlong, DeLeeuw, Lynn, Burlison, Joseph A., Chaires, Jonathan B., Trent, John O., Li, Chi

“…The proapoptotic Bcl-2 protein Bax by itself is sufficient to initiate apoptosis in almost all apoptotic paradigms. Thus, compounds that can facilitate…”
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Multi-group diagnostic classification of high-dimensional data using differential scanning calorimetry plasma thermograms by Rai, Shesh N, Srivastava, Sudhir, Pan, Jianmin, Wu, Xiaoyong, Rai, Somesh P, Mekmaysy, Chongkham S, DeLeeuw, Lynn, Chaires, Jonathan B, Garbett, Nichola C

“…The thermoanalytical technique differential scanning calorimetry (DSC) has been applied to characterize protein denaturation patterns (thermograms) in blood…”
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Characterization and classification of lupus patients based on plasma thermograms by Garbett, Nichola C, Brock, Guy N, Chaires, Jonathan B, Mekmaysy, Chongkham S, DeLeeuw, Lynn, Sivils, Kathy L, Harley, John B, Rovin, Brad H, Kulasekera, K B, Jarjour, Wael N

“…Plasma thermograms (thermal stability profiles of blood plasma) are being utilized as a new diagnostic approach for clinical assessment. In this study, we…”
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Abstract 1789 Structural Characterization and Targeting of Higher-order DNA G-quadruplexes by Monsen, Robert, DeLeeuw, Lynn, Chaires, Jonathan, Trent, John

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Clinical application of plasma thermograms. Utility, practical approaches and considerations by Garbett, Nichola C., Mekmaysy, Chongkham S., DeLeeuw, Lynn, Chaires, Jonathan B.

“…•DSC analysis of biofluids is an emerging area with application to clinical diagnostics.•DSC profiles are sensitive to changes in the thermal properties of…”
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Structural characterization and targeting of higher-order promoter G-quadruplexes by Monsen, Robert C., DeLeeuw, Lynn W., Dean, William L., Gray, Robert D., Chakravarthy, Srinivas, Hopkins, Jesse B., Chaires, Jonathan B., Trent, John O.

“…Abstract only…”
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Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer by Khan, Nazimuddin, Shah, Parag P., Ban, David, Trigo-Mouriño, Pablo, Carneiro, Marta G., DeLeeuw, Lynn, Dean, William L., Trent, John O., Beverly, Levi J., Konrad, Manfred, Lee, Donghan, Sabo, T. Michael

“…Human guanylate kinase (hGMPK) is the only known enzyme responsible for cellular GDP production, making it essential for cellular viability and proliferation…”
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Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation by Dean, William L, Gray, Robert D, DeLeeuw, Lynn, Monsen, Robert C, Chaires, Jonathan B

“…Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This…”
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Thermodynamics and Specificity of the Mbp1−DNA Interaction by Deleeuw, Lynn, Tchernatynskaia, Anna V, Lane, Andrew N

“…The DNA binding domain of the yeast transcription factor Mbp1 is a winged helix−turn−helix structure, with an extended DNA binding site involving C-terminal…”
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Thermodynamics and Specificity of the Mbp1-DNA Interaction super([dagger]) by Tchernatynskaia, Anna V, Deleeuw, Lynn, Lane, Andrew N

“…The DNA binding domain of the yeast transcription factor Mbp1 is a winged helix-turn-helix structure, with an extended DNA binding site involving C- terminal…”
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Structural analysis of the DNA target site and its interaction with Mbp1 by Chernatynskaya, Anna V, Deleeuw, Lynn, Trent, John O, Brown, Tom, Lane, Andrew N

“…The solution structure of a 14 base-pair non-self complementary DNA duplex containing the consensus-binding site of the yeast transcription factor Mbp1 has…”
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Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Robert C Monsen, Jon M Maguire, Lynn W DeLeeuw, Jonathan B Chaires, John O Trent

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1 alpha, and vMIP-II Binding by Navenot, J M, Wang, Z X, Trent, J O, Murray, J L, Hu, Q X, DeLeeuw, L, Moore, P S, Chang, Y, Peiper, S C

“…Molecular analysis of CCR5, the cardinal coreceptor for HIV-1 infection, has implicated the N-terminal extracellular domain (N-ter) and regions vicinal to the…”
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Thermodynamics and specificity of the yeast transcription factor Mbp1-DNA interaction by DeLeeuw, Lynn W

“…Mbp1, (Mlu-1 box Binding Protein) a transcription factor from the budding yeast, Saccharomyces cerevisiae, plays a key role in the G1/S transition in the cell…”
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Molecular anatomy of CCR5 engagement by physiologic and viral chemokines and HIV-1 envelope glycoproteins: differences in primary structural requirements for RANTES, MIP-1α, and vMIP-II binding 1 1Edited by P. E. Wright by Navenot, Jean-Marc, Wang, Zi-xuan, Trent, John O, Murray, James L, Hu, Qin-xue, DeLeeuw, Lynn, Moore, Patrick S, Chang, Yuan, Peiper, Stephen C

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