Search Results - "DeLano, Frank"

Aging by autodigestion by DeLano, Frank A, Schmid-Schönbein, Geert W

“…The mechanism that triggers the progressive dysregulation of cell functions, inflammation, and breakdown of tissues during aging is currently unknown. We…”
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Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock by DeLano, Frank A, Hoyt, David B, Schmid-Schönbein, Geert W

“…Shock, sepsis, and multiorgan failure are associated with inflammation, morbidity, and high mortality. The underlying pathophysiological mechanism is unknown,…”
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Volatile Decay Products in Breath During Peritonitis Shock are Attenuated by Enteral Blockade of Pancreatic Digestive Proteases by DeLano, Frank A, Chow, Jason, Schmid-Schönbein, Geert W

“…ABSTRACTThere is a need to develop markers for early detection of organ failure in shock that can be noninvasively measured at point of care. We explore here…”
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Proteinase Activity and Receptor Cleavage: Mechanism for Insulin Resistance in the Spontaneously Hypertensive Rat by DeLano, Frank A, Schmid-Schönbein, Geert W

“…Arterial hypertension is associated with organ dysfunctions, but the mechanisms are uncertain. We hypothesized that enhanced proteolytic activity in the…”
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Continuous enteral protease inhibition as a novel treatment for experimental trauma/hemorrhagic shock by Aletti, Federico, DeLano, Frank A., Maffioli, Elisa, Mu, Hao, Schmid-Schönbein, Geert W., Tedeschi, Gabriella, Kistler, Erik B.

“…Purpose Trauma and hemorrhagic shock (T/HS) is a major cause of morbidity and mortality. Existing treatment options are largely limited to source control and…”
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Pancreatic Digestive Enzyme Blockade in the Small Intestine Prevents Insulin Resistance in Hemorrhagic Shock by DeLano, Frank A, Schmid-Schönbein, Geert W

“…ABSTRACTHemorrhagic shock is associated with metabolic defects, including hyperglycemia and insulin resistance, but the mechanisms are unknown. We recently…”
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Peptidomic Analysis of Rat Plasma: Proteolysis in Hemorrhagic Shock by Aletti, Federico, Maffioli, Elisa, Negri, Armando, Santamaria, Marco H, DeLano, Frank A, Kistler, Erik B, Schmid-Schönbein, Geert W, Tedeschi, Gabriella

“…ABSTRACTIt has been previously shown that intestinal proteases translocate into the circulation during hemorrhagic shock and contribute to proteolysis in…”
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Enhanced matrix metalloproteinase activity in the spontaneously hypertensive rat: VEGFR-2 cleavage, endothelial apoptosis, and capillary rarefaction by Tran, Edward D, DeLano, Frank A, Schmid-Schönbein, Geert W

“…Besides an elevated blood pressure, the spontaneously hypertensive rat (SHR) has multiple microvascular complications including endothelial apoptosis with…”
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Oxidative Stress Promotes Endothelial Cell Apoptosis and Loss of Microvessels in the Spontaneously Hypertensive Rats by Kobayashi, Nobuhiko, DeLano, Frank A, Schmid-Schönbein, Geert W

“…OBJECTIVE—Endothelial cell apoptosis caused by oxidative stress may lead to the loss of microvessels (rarefaction) in hypertension. We examine here the effects…”
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Receptor cleavage and P-selectin-dependent reduction of leukocyte adhesion in the spontaneously hypertensive rat by Chen, Angela Y., Ha, Jessica N., DeLano, Frank A., Schmid‐Schönbein, Geert W.

“…Elevated matrix metalloproteinase activity in the plasma of the spontaneously hypertensive rat is associated with reduced mesenteric venular extracellular…”
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Receptor cleavage reduces the fluid shear response in neutrophils of the spontaneously hypertensive rat by Chen, Angela Y, DeLano, Frank A, Valdez, Shakti R, Ha, Jessica N, Shin, Hainsworth Y, Schmid-Schönbein, Geert W

“…Physiological fluid shear stress evokes pseudopod retraction in normal leukocytes by a mechanism that involves the formyl peptide receptor (FPR) as…”
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The Inflammatory Aspect of the Microcirculation in Hypertension: Oxidative Stress, Leukocytes/Endothelial Interaction, Apoptosis by Suematsu, Makoto, Suzuki, Hidekazu, Delano, Frank A., Schmid-Schönbein, Geert W.

“…Evidence is increasing in hypertensive models for an inflammatory reaction in the microcirculation with abnormal leukocyte counts and adhesion to the…”
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Oxidative Stress in the Dahl Hypertensive Rat by Swei, Allen, Lacy, Fred, DeLano, Frank A, Schmid-Schonbein, Geert W

“…Enhanced production of oxygen free radicals may play a role in hypertension by affecting vascular smooth muscle contraction, resistance to blood flow, and…”
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Matrix Metalloproteinase Activity Causes VEGFR-2 Cleavage and Microvascular Rarefaction in Rat Mesentery by TRAN, EDWARD D., YANG, MING, CHEN, ANDREW, DELANO, FRANK A., MURFEE, WALTER L., SCHMID-SCHÖNBEIN, GEERT W.

“…Please cite this paper as: Tran, Yang, Chen, DeLano, Murfee and Schmid‐Schönbein (2011). Matrix Metalloproteinase Activity Causes VEGFR‐2 Cleavage and…”
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Xanthine Oxidase Activity Associated with Arterial Blood Pressure in Spontaneously Hypertensive Rats by Suzuki, Hidekazu, DeLano, Frank A., Parks, Dale A., Jamshidi, Neema, Granger, D. Neil, Ishii, Hiromasa, Suematsu, Makoto, Zweifach, Benjamin W., Schmid-Schonbein, Geert W.

“…Recent evidence in vivo indicates that spontaneously hypertensive rats (SHR) exhibit an increase in oxyradical production in and around microvascular…”
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The primary valves in the initial lymphatics during inflammation by Lynch, Patrick M, Delano, Frank A, Schmid-Schönbein, Geert W

“…The primary valve system in the initial lymphatics prevents fluid transport from the initial lymphatics back into the interstitium. The authors hypothesize…”
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The importance of organizational level decision latitude for well-being and organizational commitment by Dhondt, Steven, Delano Pot, Frank, O. Kraan, Karolus

“…Purpose - This paper aims to focus on participation in the workplace and examines the relative importance of different dimensions of job control in relation to…”
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The Leukocyte Response to Fluid Stress by Moazzam, Fariborz, DeLano, Frank A., Zweifach, Benjamin W., Schmid-Schönbein, Geert W.

“…Leukocyte migration from a hemopoietic pool across marrow endothelium requires active pseudopod formation and adhesion. Leukocytes rarely show pseudopod…”
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Microvascular Display of Xanthine Oxidase and NADPH Oxidase in the Spontaneously Hypertensive Rat by Delano, Frank A., Parks, Dale A., Ruedi, Julie M., Babior, Bernard M., Schmid-Schönbein, Geert W.

“…Objective: Oxygen free radical production in hypertension may be associated with elevated arteriolar tone and organ injury. Previous results suggest an…”
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Enteral and peritoneal blockade of serine proteolytic enzymes accelerates post-surgical bowel function recovery by Saltzman, Darin J., MD, PhD, DeLano, Frank A., MS, Schmid-Schönbein, Geert W., PhD

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