Search Results - "DeLanney, L.E."

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum by Ricaurte, G A, Langston, J W, DeLanney, L E, Irwin, I, Brooks, J D

“…1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a recently described neurotoxin, produces a marked dopamine (DA) depletion in the mouse striatum. In this…”
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Novel observations with FDOPA-PET imaging after early nigrostriatal damage by Yee, R.E., Irwin, I., Milonas, C., Stout, D.B., Huang, S-C., Shoghi-Jadid, K., Satyamurthy, N., Delanney, L.E., Togasaki, D.M., Farahani, K.F., Delfani, K., Janson, A.M., Phelps, M.E., Langston, J.W., Barrio, J.R.

“…Striatal 6‐[18F]fluoro‐L‐DOPA (FDOPA) kinetic rate constants were measured by positron emission tomography (PET) in…”
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Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration by Ricaurte, G A, DeLanney, L E, Irwin, I, Langston, J W

“…This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central…”
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Nigrostriatal Reduction of Aromatic L‐Amino Acid Decarboxylase Activity in MPTP‐Treated Squirrel Monkeys: In Vivo and In Vitro Investigations by Yee, R.E., Huang, S.‐C., Stout, D.B., Irwin, I., Shoghi‐Jadid, K., Togaski, D.M., DeLanney, L.E., Langston, J.W., Satyamurthy, N., Farahani, K.F., Phelps, M.E., Barrio, J.R.

“…Aromatic L‐amino acid decarboxylase (AAAD) activity was examined in vivo with positron emission tomography (PET) using 6‐[18F]fluoro‐L‐DOPA (FDOPA) in squirrel…”
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Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra by Ricaurte, G A, Irwin, I, Forno, L S, DeLanney, L E, Langston, E, Langston, J W

“…This study assessed the influence of aging on substantia nigra degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Extensive neuronal…”
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5-Hydroxyindoleacetic acid in cerebrospinal fluid reflects serotonergic damage induced by 3,4-methylenedioxymethamphetamine in CNS of non-human primates by Ricaurte, G A, DeLanney, L E, Wiener, S G, Irwin, I, Langston, J W

“…This study examined whether 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) could be used to detect serotonergic damage induced by…”
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Older dopaminergic neurons do not recover from the effects of MPTP by Ricaurte, G A, DeLanney, L E, Irwin, I, Langston, J W

“…Recent studies have shown that dopaminergic neurons in young mature mice recover fully from toxic injury induced by MPTP. The aim of the present study was to…”
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3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain by Ricaurte, G A, Finnegan, K F, Nichols, D E, DeLanney, L E, Irwin, I, Langston, J W

“…The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic…”
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Evaluation of the neurotoxic potential of N,N-dimethylamphetamine: an illicit analog of methamphetamine by Ricaurte, G A, DeLanney, L E, Irwin, I, Witkin, J M, Katz, J L, Langston, J W

“…The purpose of this study was to evaluate the neurotoxic potential of N,N-dimethylamphetamine (N,N-DMA), a controlled substance analog that has recently…”
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The dopamine-depleting effect of 6-hydroxydopamine does not increase with aging by Ricaurte, G A, DeLanney, L E, Finnegan, K T, Irwin, I, Langston, J W

“…The dopamine-depleting effects of intracerebroventricularly administered 6-hydroxydopamine (6-OHDA) were studied in young mature (6-8 weeks), older (8-12…”
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