Histamine receptors in urethrovesical smooth muscle

Histamine receptors in urethrovesical smooth muscle

Through the method of pharmacologic antagonism, the contractile effect of histamine was studied simultaneously on isolated smooth muscle preparations obtained from the body and base of the bladder and from the proximal urethra of the guinea pig. Histamine had a contractile effect mediated specifical...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) Vol. 10; no. 4; p. 375
Main Authors: Khanna, O P, DeGregorio, G J, Sample, R C, McMichael, R F
Format: Journal Article
Language:English
Published: United States 01-10-1977
Subjects:
Acetylcholine - pharmacology
Animals
Dogs
Female
Guinea Pigs
Histamine - pharmacology
Humans
Male
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
Receptors, Histamine - physiology
Receptors, Histamine H1 - physiology
Receptors, Histamine H2 - physiology
Urethra - drug effects
Urethra - physiology
Urinary Bladder - drug effects
Urinary Bladder - physiology
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Summary:Through the method of pharmacologic antagonism, the contractile effect of histamine was studied simultaneously on isolated smooth muscle preparations obtained from the body and base of the bladder and from the proximal urethra of the guinea pig. Histamine had a contractile effect mediated specifically through H1 receptors, with no H2 activity. This effect was most marked in the body of the bladder, comparatively moderate in the base, and slight in the proximal urethra. It appears that histamine effect is not mediated through either a cholinergic or an adrenergic mechanism. Clinical implications are discussed.
ISSN:0090-4295
DOI:10.1016/0090-4295(77)90171-6