Search Results - "DeGregori, James"

Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments by DeGregori, James

“…In a recent article in , Tomasetti and colleagues present an expanded model for cancer risk, which they claim demonstrates the relative contribution of…”
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Cancer as a disease of old age: changing mutational and microenvironmental landscapes by Laconi, Ezio, Marongiu, Fabio, DeGregori, James

“…Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and…”
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Of mice, genes and aging by DeGregori, James

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The special issue on cancer and evolution: Lessons learned by DeGregori, James

“…This special issue of evolutionary applications focused on the evolution of cancer has provided a wealth of different viewpoints and results from leaders in…”
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The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease by Marongiu, Fabio, DeGregori, James

“…Aging represents the major risk factor for the development of cancer and many other diseases. Recent findings show that normal tissues become riddled with…”
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Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations by Rozhok, Andrii I, James DeGregori

“…Our understanding of cancer has greatly advanced since Nordling [Nordling CO (1953) Br J Cancer 7(1):68–72] and Armitage and Doll [Armitage P, Doll R (1954)…”
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Aging and Cancer: A new forum for research that spans disciplines and seeks new answers by DeGregori, James

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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells by Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

“…In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We…”
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A generalized theory of age-dependent carcinogenesis by Rozhok, Andrii, DeGregori, James

“…The Multi-Stage Model of Carcinogenesis (MMC), developed in the 1950 s-70s, postulated carcinogenesis as a Darwinian somatic selection process. The cellular…”
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Targeting Glutamine Metabolism and Redox State for Leukemia Therapy by Gregory, Mark A, Nemkov, Travis, Park, Hae J, Zaberezhnyy, Vadym, Gehrke, Sarah, Adane, Biniam, Jordan, Craig T, Hansen, Kirk C, D'Alessandro, Angelo, DeGregori, James

“…Acute myeloid leukemia (AML) is a hematologic malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to…”
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Somatic maintenance impacts the evolution of mutation rate by Rozhok, Andrii, DeGregori, James

“…The evolution of multi-cellular animals has produced a conspicuous trend toward increased body size. This trend has introduced at least two novel problems: an…”
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Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis by DeGregori, James, Johnson, David G

“…Since the discovery almost fifteen years ago that E2F transcription factors are key targets of the retinoblastoma protein (RB), studies of the E2F family have…”
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Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II by Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Culp-Hill, Rachel, Reisz, Julie A., Pei, Shanshan, Gustafson, Annika, Khan, Nabilah, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

“…We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from patients with acute…”
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Clonal hematopoiesis: Mutation-specific adaptation to environmental change by Florez, Marcus A, Tran, Brandon T, Wathan, Trisha K, DeGregori, James, Pietras, Eric M, King, Katherine Y

“…Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially…”
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The genetics of the E2F family of transcription factors: shared functions and unique roles by DeGregori, James

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Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia by Evans, Jr, Edward J, DeGregori, James

“…Individuals with Down syndrome (DS) have more than 100-fold increased risk of acute megakaryoblastic leukemia (AMKL), but its pathogenesis is poorly…”
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Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors by Higa, Kelly C, Goodspeed, Andrew, Chavez, James S, De Dominici, Marco, Danis, Etienne, Zaberezhnyy, Vadym, Rabe, Jennifer L, Tenen, Daniel G, Pietras, Eric M, DeGregori, James

“…The early events that drive myeloid oncogenesis are not well understood. Most studies focus on the cell-intrinsic genetic changes and how they impact cell fate…”
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Trisomy 21 consistently activates the interferon response by Sullivan, Kelly D, Lewis, Hannah C, Hill, Amanda A, Pandey, Ahwan, Jackson, Leisa P, Cabral, Joseph M, Smith, Keith P, Liggett, L Alexander, Gomez, Eliana B, Galbraith, Matthew D, DeGregori, James, Espinosa, Joaquín M

“…Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary…”
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A new role for E2F1 in DNA repair: All for the greater good by DeGregori, James

“…Comment on: Chen J, et al. Cell Cycle 2011; 10:1287-94…”
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The three dimensions of somatic evolution: Integrating the role of genetic damage, life‐history traits, and aging in carcinogenesis by Rozhok, Andrii I., DeGregori, James

“…Tumors result from genetic and epigenetic alterations that change cellular survival and differentiation probabilities, promoting clonal dominance. Subsequent…”
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