Search Results - "DeGrange, Paula"

Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques by Srinivasula, Sharat, Degrange, Paula, Perazzolo, Simone, Bonvillain, Andrew, Tobery, Amanda, Kaplan, Jacob, Jang, Hyukjin, Turnier, Refika, Davies, Michael, Cottrell, Mackenzie, Ho, Rodney J Y, Di Mascio, Michele

“…To understand the relationship between immunovirological factors and antiretroviral (ARV) drug levels in lymph nodes (LN) in HIV therapy, we analyzed drug…”
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CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies by Srinivasula, Sharat, Gabriel, Erin, Kim, Insook, DeGrange, Paula, St Claire, Alexis, Mallow, Candace, Donahue, Robert E, Paik, Chang, Lane, H C, Di Mascio, Michele

“…Rapidly increasing number of therapeutic antibodies are being repurposed to imaging probes for noninvasive diagnosis, as well as monitoring during treatment or…”
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Models of Systemic Lupus Erythematosus: Development of Autoimmunity Following Peptide Immunizations of Noninbred Pedigreed Rabbits by Rai, Geeta, Ray, Satyajit, Shaw, Robyn E, DeGrange, Paula F, Mage, Rose G, Newman, Barbara A

“…Reported in this study are the initial results from studies to develop rabbit models of systemic lupus erythematosus (SLE) by immunizations using two distinct…”
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Quantitative PET imaging of the CD4 pool in nonhuman primates by Kim, Insook, Srinivasula, Sharat, DeGrange, Paula, Long, Brad, Jang, Hyukjin, Carrasquillo, Jorge A., Lane, H. Clifford, Di Mascio, Michele

“…Purpose Previous SPECT and PET semi-quantitative in vivo imaging studies in monkeys have demonstrated specific uptake of radiolabeled rhesus recombinant…”
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Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study by Donahue, Robert E., Srinivasula, Sharat, Uchida, Naoya, Kim, Insook, St. Claire, Alexis, Duralde, Gorka, DeGrange, Paula, St. Claire, Marisa, Reba, Richard C., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Paik, Chang H., Lane, H. Clifford, Tisdale, John F., Di Mascio, Michele

“…Ionizing irradiation is used routinely to induce myeloablation and immunosuppression. However, it has not been possible to evaluate the extent of ablation…”
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Decreases in IL-7 levels during antiretroviral treatment of HIV infection suggest a primary mechanism of receptor-mediated clearance by Hodge, Jessica N., Srinivasula, Sharat, Hu, Zonghui, Read, Sarah W., Porter, Brian O., Kim, Insook, Mican, JoAnn M., Paik, Chang, DeGrange, Paula, Di Mascio, Michele, Sereti, Irini

“…IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought to be due to increased…”
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Monitoring Immune Activation with Whole-Body Fluorodeoxyglucose-Positron-Emission Tomography in Simian Immunodeficiency Virus-Infected Rhesus Macaques by Sinharay, Sanhita, Srinivasula, Sharat, Schreiber-Stainthorp, William, Shah, Swati, Degrange, Paula, Bonvillain, Andrew, Wang, Jing, Dodd, Lori, Carrasquillo, Jorge A, Hammoud, Dima A, Di Mascio, Michele

“…This study aimed to assess immune activation in tissues by measuring glucose metabolism with F-fluorodeoxyglucose (FDG) and investigate the associations of…”
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Evaluation of CD4+ Cell Recovery in Vivo Using Single Photon Emission Tomography (SPECT) in Real Time Following CD34+ Cell Transplantation in Rhesus Macaques by Donahue, Robert E., Srinivasula, Sharat, Uchida, Naoya, Kim, Insook, Duralde, Gorka, DeGrange, Paula, St. Claire, Marisa, Reba, Richard C., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Paik, Chang H., Lane, H. Clifford, Tisdale, John F., Di Mascio, Michele

“…It has not been possible to evaluate immune recovery in tissues without invasive biopsy. Investigators have had to rely on peripheral blood lymphocytes (PBLs)…”
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Discordance Between Peripheral Blood and Tissue CD4+ Lymphocyte Reconstitution In Rhesus Monkeys Following Autologous Hematopoietic CD34+ Cell Transplantation: An In Vivo imaging Study by Donahue, Robert E., Srinivasula, Sharat, Uchida, Naoya, Kim, Insook, Duralde, Gorka, DeGrange, Paula, St. Claire, Marisa, Reba, Richard C., Bonifacino, Aylin C., Krouse, Allen E., Metzger, Mark E., Paik, Chang H., Lane, H. Clifford, Tisdale, John F., Di Mascio, Michele

“…Historically lymphocyte (Lc) recovery following hematopoietic transplantation, immunosuppressive therapies, and infectious diseases has relied quite heavily on…”
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Total body CD4+ T cell dynamics in treated and untreated SIV infection revealed by in vivo imaging by Di Mascio, Michele, Srinivasula, Sharat, Kim, Insook, Duralde, Gorka, St Claire, Alexis, DeGrange, Paula, St Claire, Marisa, Reimann, Keith A, Gabriel, Erin E, Carrasquillo, Jorge, Reba, Richard C, Paik, Chang, Lane, Henry C

“…The peripheral blood represents only a small fraction of the total number of lymphocytes in the body. To develop a more thorough understanding of T cell…”
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