Search Results - "DeGraba, T"

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody : A bedside-to-bench study by FURUYA, Kazuhide, TAKEDA, Hidetaka, DEL ZOPPO, Gregory J, HALLENBECK, John M, AZHAR, Salman, MCCARRON, Richard M, YONG CHEN, RUETZLER, Christl A, WOLCOTT, Karen M, DEGRABA, Thomas J, ROTHLEIN, Robert, HUGLI, Tony E

“…Enlimomab, a murine monoclonal anti-human intercellular adhesion molecule (ICAM)-1 antibody, had a negative outcome in a multicenter acute-stroke trial. We did…”
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The role of inflammation after acute stroke: utility of pursuing anti-adhesion molecule therapy by DeGraba, T J

“…A growing body of evidence, primarily from animal models of cerebral ischemia and preliminary human studies, indicates that inflammatory mechanisms contribute…”
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Profile of endothelial and leukocyte activation in fabry patients by DeGraba, Thomas, Azhar, Salman, Dignat-George, Françoise, Brown, Eric, Boutière, Brigitte, Altarescu, Gheona, McCarron, Richard, Schiffmann, Raphael

“…Fabry disease is an X‐linked recessive disorder resulting in the deposition of globotriaosylceramide in numerous cell types including vascular endothelial…”
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Expression of inflammatory mediators and adhesion molecules in human atherosclerotic plaque by DEGRABA, T. J

“…The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Evidence suggests that mediators of inflammation not only are…”
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Why do neuroprotective drugs work in animals but not humans? by DeGraba, T J, Pettigrew, L C

“…Many neuroprotective agents that seemed promising in animal studies of ischemic brain injury prove to have no effect when tested in clinical trials, suggesting…”
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Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque by DEGRABA, T. J, SIREN, A.-L, PENIX, L, MCCARRON, R. M, HARGRAVES, R, SOOD, S, PETTIGREW, K. D, HALLENBECK, J. M

“…The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Evidence suggests that mediators of inflammation are not only…”
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Progression in acute stroke: value of the initial NIH stroke scale score on patient stratification in future trials by DeGraba, T J, Hallenbeck, J M, Pettigrew, K D, Dutka, A J, Kelly, B J

“…The objective was to determine the occurrence of neurological changes during the first 48 hours after acute stroke as it relates to initial stroke severity…”
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Presence of Chlamydia pneumoniae in human symptomatic and asymptomatic carotid atherosclerotic plaque by LABICHE, Ronald, KOZIOL, Deloris, QUINN, Thomas C, GAYDOS, Charlotte, AZHAR, Salman, KETRON, Gary, SOOD, Suman, DEGRABA, Thomas J

“…Chlamydia pneumoniae has been identified in atherosclerotic plaques of patients with cerebrovascular and cardiovascular disease. However, the direct causative…”
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Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis by WORRALL, Bradford B, AZHAR, Salman, NYQUIST, Paul A, ACKERMAN, Robert H, HAMM, Theresa L, DEGRABA, Thomas J

“…Inflammation plays an important role in the development of atherosclerosis. The gene for the counterinflammatory cytokine interleukin-1 receptor antagonist…”
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1103 Understanding the Role of Sleep as a Risk Factor for Suicidal Ideation in Active Duty Service Members by Paxton Willing, M M, Pickett, T C, Tate, L L, Rhodes, C, DeGraba, T

“…Abstract Introduction Suicide is an important public health concern with many factors contributing to increased risk. Sleep is one such factor that may elevate…”
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Threshold of calcium disturbances after focal cerebral ischemia in rats. Implications of the window of therapeutic opportunity by DeGraba, T J, Ostrow, P T, Grotta, J C

“…One explanation for inconclusive results with calcium channel blockers in human acute stroke trials may be incomplete information about the time course of…”
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Motor performance, histologic damage, and calcium influx in rats treated with NBQX after focal ischemia by DeGraba, T J, Ostrow, P, Hanson, S, Grotta, J C

“…2,3-Dihydroxy-6-nitro-7-sulfamoylbenzo(F)-quinoxaline (NBQX), an alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist, has been…”
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Increased CD8(+) T cells associated with Chlamydia pneumoniae in symptomatic carotid plaque by Nadareishvili, Z G, Koziol, D E, Szekely, B, Ruetzler, C, LaBiche, R, McCarron, R, DeGraba, T J

“…The presence of Chlamydia pneumoniae has been reported in carotid atheroma, but its causative effect in the activation of an atherosclerotic plaque to a…”
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Genetics of ischemic stroke by DeGraba, T J, Penix, L

“…Advances in the study of cerebrovascular disease suggest that many risk factors for stroke are under genetic influence. Epidemiologic studies show that…”
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Temporal relation of calcium-calmodulin binding and neuronal damage after global ischemia in rats by DEGRABA, T. J, OSTROW, P. T, STRONG, R. A, EARLS, R. M, ZONG, Z. J, GROTTA, J. C

“…This study explores the temporal relation of the severity of ischemia and calcium-calmodulin binding in vulnerable and resistant brain regions in a commonly…”
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Immunological aspects of acute stroke: therapeutic implications by DeGraba, T J

“…Recent studies strongly suggest that cerebral ischaemia initiates a focal inflammatory response that results in significant secondary injury to brain…”
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Use of anti-ICAM-1 therapy in ischemic stroke: Results of the Enlimomab Acute Stroke Trial

“…There has been recent interest in the possible role of reperfusion-induced inflammation with neuronal injury after stroke. Enlimomab, a murine intercellular…”
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Tissue Plasminogen Activator for Acute Ischemic Stroke by Marler, John R

“…Ischemic stroke affects over 400,000 people in the United States annually, 1 and there is no direct treatment to reduce the extent of neurologic injury…”
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Recombinant Tissue Plasminogen Activator for Minor Strokes: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Experience by The National Institute of Neurological Disorders Stroke rt-PA Stroke Study Group

“…Acute ischemic stroke patients eligible for tissue plasminogen activator and with less severe neurologic deficits, although still generally benefiting from…”
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Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience by Lattimore, Susan Unipan, Chalela, Julio, Davis, Lisa, DeGraba, Thomas, Ezzeddine, Mustapha, Haymore, Joseph, Nyquist, Paul, Baird, Alison E, Hallenbeck, John, Warach, Steven

“…To increase the proportion of ischemic stroke patients treated with thrombolytic therapy, the establishment of primary stroke centers in community hospitals…”
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