Search Results - "DeClue, JE"

Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis by Ling, Benjamin C., Wu, Jianqiang, Miller, Shyra J., Monk, Kelly R., Shamekh, Rania, Rizvi, Tilat A., DeCourten-Myers, Gabrielle, Vogel, Kristine S., DeClue, Jeffrey E., Ratner, Nancy

“…Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor…”
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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination by Benvenuto, G, Li, S, Brown, S J, Braverman, R, Vass, W C, Cheadle, J P, Halley, D J, Sampson, J R, Wienecke, R, DeClue, J E

“…We report here that overexpression of the tuberous sclerosis-1 (TSC1) gene product hamartin results in the inhibition of growth, as well as changes in cell…”
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Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY by Wienecke, Ralf, König, Adrian, DeClue, Jeffrey E.

“…Tuberous sclerosis (TSC) is a human genetic syndrome characterized by the development of benign tumors in a variety of tissues, as well as rare malignancies…”
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Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models by DeClue, J E, Heffelfinger, S, Benvenuto, G, Ling, B, Li, S, Rui, W, Vass, W C, Viskochil, D, Ratner, N

“…We have found that EGF-R expression is associated with the development of the Schwann cell-derived tumors characteristic of neurofibromatosis type 1 (NF1) and…”
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Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase by Soucek, T, Pusch, O, Wienecke, R, DeClue, J E, Hengstschläger, M

“…Tuberous sclerosis is an autosomal dominant disorder characterized by the development of benign growths in many tissues and organs. Linkage analysis revealed…”
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Epidermal growth factor receptor signaling pathways are associated with tumorigenesis in the Nf1:p53 mouse tumor model by HONGZHEN LI, VELASCO-MIGUEL, Susana, VASS, William C, PARADA, Luis F, DECLUE, Jeffrey E

“…The human disease neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene, and is characterized by the formation of benign and malignant tumors…”
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Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin by HODGES, Angela K, SHAOWEI LI, MAYNARD, Julie, PARRY, Lee, BRAVERMAN, Richard, CHEADLE, Jeremy P, DECLUE, Jeffrey E, SAMPSON, Julian R

“…Critical functions of hamartin and tuberin, encoded by the TSC1 and TSC2 genes, are likely to be closely linked. The proteins interact directly with one…”
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cAMP-dependent protein kinase A is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways by Kim, Haesun A., DeClue, Jeffrey E., Ratner, Nancy

“…Schwann cell proliferation is stimulated by contact with neurons or exposure to growth factor ligands for tyrosine kinase receptors, effects of which are…”
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Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology by Ess, Kevin C., Uhlmann, Erik J., Li, Wen, Li, Hongzhen, Declue, Jeffrey E., Crino, Peter B., Gutmann, David H.

“…Individuals with tuberous sclerosis complex (TSC) exhibit a variety of neurologic abnormalities, including mental retardation, epilepsy, and autism…”
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Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf by Anborgh, Pieter H., Qian, Xiaolan, Papageorge, Alex G., Vass, William C., DeClue, Jeffrey E., Lowy, Douglas R.

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Suppression of Tumorigenicity by the Wild-Type Tuberous Sclerosis 2 (Tsc2) Gene and its C-Terminal Region by Jin, Fang, Wienecke, Ralf, Xiao, Guang-Hui, Maize, John C., DeClue, Jeffrey E., Yeung, Raymond S.

“…The Tsc2 gene, which is mutationally inactivated in the germ line of some families with tuberous sclerosis, encodes a large, membrane-associated GTPase…”
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Brain Lipid Binding Protein in Axon-Schwann Cell Interactions and Peripheral Nerve Tumorigenesis by Miller, Shyra J., Li, Hongzhen, Rizvi, Tilat A., Huang, Yuan, Johansson, Gunnar, Bowersock, Jason, Sidani, Amer, Vitullo, John, Vogel, Kristine, Parysek, Linda M., DeClue, Jeffrey E., Ratner, Nancy

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus by Wienecke, R, Maize, Jr, J C, Shoarinejad, F, Vass, W C, Reed, J, Bonifacino, J S, Resau, J H, de Gunzburg, J, Yeung, R S, DeClue, J E

“…Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome…”
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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras by JOHNSON, M. R, LOOK, T, DECLUE, J. E, VALENTINE, M. B, LOWY, D. R

“…The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively…”
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Identification and Characterization of the Neurofibromatosis Type 1 Protein Product by DeClue, Jeffrey E., Cohen, Bruce D., Lowy, Douglas R.

“…The neurofibromatosis type 1 (NF1) gene responsible for von Recklinghausen neurofibromatosis is related to regulators of ras proteins, and a portion of NF1…”
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Inactivation of the NF1 Gene in Human Melanoma and Neuroblastoma Cell Lines Without Impaired Regulation of GTP·Ras by Johnson, Maureen R., Look, A. Thomas, DeClue, Jeffrey E., Valentine, Marcus B., Lowy, Douglas R.

“…The NF1 gene, which is altered in patients with type 1 neurofibromatosis, encodes neurofibromin, a protein whose GTPase-activating function can negatively…”
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Tuberous sclerosis in a 20-week gestation fetus : immunohistochemical study by PARK, S.-H, PEPKOWITZ, S. H, KERFOOT, C, DE ROSA, M. J, POUKENS, V, WIENECKE, R, DECLUE, J. E, VINTERS, H. V

“…We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical…”
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Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues by Wienecke, R, Maize, JC, Jr, Reed, JA, de Gunzburg, J, Yeung, RS, DeClue, JE

“…The tuberous sclerosis-2 (TSC2) gene is linked to tuberous sclerosis (TSC), a dominantly inherited genetic syndrome in which inactivation of the normal TSC2…”
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Regulation of cell morphology and adhesion by the tuberous sclerosis complex (TSC1/2) gene products in human kidney epithelial cells through increased E- cadherin/[beta]-catenin activity by Li, S, Braverman, R, Li, H, Vass, W C, Lowy, DR, DeClue, JE

“…We investigated the effects of overexpression of the tuberous sclerosis-1 and-2 (TSC1/2) gene products (hamartin and tuberin, respectively) in the human kidney…”
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Suppression of c- ras transformation by GTPase-activating protein by Zhang, Ke, DeClue, Jeffrey E, Vass, William C, Papageorge, Alex G, McCormick, Frank, Lowy, Douglas R

“…The ras genes are required for normal cell growth and mediate transformation by oncogenes encoding protein tyrosine kinases. Normal ras can transform cells in…”
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