Search Results - "DeCarvalho, Ana"

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma by deCarvalho, Ana C., Kim, Hoon, Poisson, Laila M., Winn, Mary E., Mueller, Claudius, Cherba, David, Koeman, Julie, Seth, Sahil, Protopopov, Alexei, Felicella, Michelle, Zheng, Siyuan, Multani, Asha, Jiang, Yongying, Zhang, Jianhua, Nam, Do-Hyun, Petricoin, Emanuel F., Chin, Lynda, Mikkelsen, Tom, Verhaak, Roel G. W.

“…To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the…”
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment by Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C., Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Sauvé, Charles-Etienne Gabriel, Olar, Adriana, Lan, Zheng D., Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Gabrusiewicz, Konrad R., Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A., Muller, Florian, Heimberger, Amy B., Sulman, Erik P., Nam, Do-Hyun, Verhaak, Roel G.W.

“…We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene expression profiles to define three tumor-intrinsic transcriptional…”
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Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription by Zhu, Yanfen, Gujar, Amit D., Wong, Chee-Hong, Tjong, Harianto, Ngan, Chew Yee, Gong, Liang, Chen, Yi-An, Kim, Hoon, Liu, Jihe, Li, Meihong, Mil-Homens, Adam, Maurya, Rahul, Kuhlberg, Chris, Sun, Fanyue, Yi, Eunhee, deCarvalho, Ana C., Ruan, Yijun, Verhaak, Roel G.W., Wei, Chia-Lin

“…Extrachromosomal, circular DNA (ecDNA) is emerging as a prevalent yet less characterized oncogenic alteration in cancer genomes. We leverage ChIA-PET and…”
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A serum-based DNA methylation assay provides accurate detection of glioma by Sabedot, Thais S, Malta, Tathiane M, Snyder, James, Nelson, Kevin, Wells, Michael, deCarvalho, Ana C, Mukherjee, Abir, Chitale, Dhananjay A, Mosella, Maritza S, Sokolov, Artem, Asmaro, Karam P, Robin, Adam, Rosenblum, Mark L, Mikkelsen, Tom, Rock, Jack, Poisson, Laila M, Lee, Ian, Walbert, Tobias, Kalkanis, Steven, Iavarone, Antonio, Castro, Ana Valeria, Noushmehr, Houtan

“…Abstract Background The detection of somatic mutations in cell-free DNA (cfDNA) from liquid biopsy has emerged as a noninvasive tool to monitor the follow-up…”
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Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment by Wang, Qianghu, Hu, Baoli, Hu, Xin, Kim, Hoon, Squatrito, Massimo, Scarpace, Lisa, deCarvalho, Ana C., Lyu, Sali, Li, Pengping, Li, Yan, Barthel, Floris, Cho, Hee Jin, Lin, Yu-Hsi, Satani, Nikunj, Martinez-Ledesma, Emmanuel, Zheng, Siyuan, Chang, Edward, Gabriel Sauvé, Charles-Etienne, Olar, Adriana, Lan, Zheng D., Finocchiaro, Gaetano, Phillips, Joanna J., Berger, Mitchel S., Gabrusiewicz, Konrad R., Wang, Guocan, Eskilsson, Eskil, Hu, Jian, Mikkelsen, Tom, DePinho, Ronald A., Muller, Florian, Heimberger, Amy B., Sulman, Erik P., Nam, Do-Hyun, Verhaak, Roel G.W.

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Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells by Shimada, Kenichi, Reznik, Eduard, Stokes, Michael E, Krishnamoorthy, Lakshmi, Bos, Pieter H, Song, Yuyu, Quartararo, Christine E, Pagano, Nen C, Carpizo, Darren R, deCarvalho, Ana C, Lo, Donald C, Stockwell, Brent R

“…Transition metals are essential, but deregulation of their metabolism causes toxicity. Here, we report that the compound NSC319726 binds copper to induce…”
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Mechanisms of Glioma Formation: Iterative Perivascular Glioma Growth and Invasion Leads to Tumor Progression, VEGF-Independent Vascularization, and Resistance to Antiangiogenic Therapy by Baker, Gregory J, Yadav, Viveka Nand, Motsch, Sebastien, Koschmann, Carl, Calinescu, Anda-Alexandra, Mineharu, Yohei, Camelo-Piragua, Sandra Ines, Orringer, Daniel, Bannykh, Serguei, Nichols, Wesley S, deCarvalho, Ana C, Mikkelsen, Tom, Castro, Maria G, Lowenstein, Pedro R

“…Abstract As glioma cells infiltrate the brain they become associated with various microanatomic brain structures such as blood vessels, white matter tracts,…”
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MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1 by Bier, Ariel, Giladi, Nis, Kronfeld, Noan, Lee, Hae Kyung, Cazacu, Simona, Finniss, Susan, Xiang, Cunli, Poisson, Laila, deCarvalho, Ana C, Slavin, Shimon, Jacoby, Elad, Yalon, Michal, Toren, Amos, Mikkelsen, Tom, Brodie, Chaya

“…Glioblastomas (GBM), the most common and aggressive malignant astrocytic tumors, contain a small subpopulation of cancer stem cells (GSCs) that are implicated…”
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Detection of diagnostic and prognostic methylation-based signatures in liquid biopsy specimens from patients with meningiomas by Herrgott, Grayson A., Snyder, James M., She, Ruicong, Malta, Tathiane M., Sabedot, Thais S., Lee, Ian Y., Pawloski, Jacob, Podolsky-Gondim, Guilherme G., Asmaro, Karam P., Zhang, Jiaqi, Cannella, Cara E., Nelson, Kevin, Thomas, Bartow, deCarvalho, Ana C., Hasselbach, Laura A., Tundo, Kelly M., Newaz, Rehnuma, Transou, Andrea, Morosini, Natalia, Francisco, Victor, Poisson, Laila M., Chitale, Dhananjay, Mukherjee, Abir, Mosella, Maritza S., Robin, Adam M., Walbert, Tobias, Rosenblum, Mark, Mikkelsen, Tom, Kalkanis, Steven, Tirapelli, Daniela P. C., Weisenberger, Daniel J., Carlotti, Carlos G., Rock, Jack, Castro, Ana Valeria, Noushmehr, Houtan

“…Recurrence of meningiomas is unpredictable by current invasive methods based on surgically removed specimens. Identification of patients likely to recur using…”
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Sox2 Promotes Malignancy in Glioblastoma by Regulating Plasticity and Astrocytic Differentiation by Berezovsky, Artem D, Poisson, Laila M, Cherba, David, Webb, Craig P, Transou, Andrea D, Lemke, Nancy W, Hong, Xin, Hasselbach, Laura A, Irtenkauf, Susan M, Mikkelsen, Tom, deCarvalho, Ana C

“…Abstract The high-mobility group–box transcription factor sex-determining region Y–box 2 (Sox2) is essential for the maintenance of stem cells from early…”
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Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Barekatain, Yasaman, Ackroyd, Jeffrey J., Yan, Victoria C., Khadka, Sunada, Wang, Lin, Chen, Ko-Chien, Poral, Anton H., Tran, Theresa, Georgiou, Dimitra K., Arthur, Kenisha, Lin, Yu-Hsi, Satani, Nikunj, Ballato, Elliot S., Behr, Eliot I., deCarvalho, Ana C., Verhaak, Roel G. W., de Groot, John, Huse, Jason T., Asara, John M., Kalluri, Raghu, Muller, Florian L.

“…Homozygous deletion of methylthioadenosine phosphorylase ( MTAP ) in cancers such as glioblastoma represents a potentially targetable vulnerability. Homozygous…”
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A Distinct DNA Methylation Shift in a Subset of Glioma CpG Island Methylator Phenotypes during Tumor Recurrence by de Souza, Camila Ferreira, Sabedot, Thais S., Malta, Tathiane M., Stetson, Lindsay, Morozova, Olena, Sokolov, Artem, Laird, Peter W., Wiznerowicz, Maciej, Iavarone, Antonio, Snyder, James, deCarvalho, Ana, Sanborn, Zachary, McDonald, Kerrie L., Friedman, William A., Tirapelli, Daniela, Poisson, Laila, Mikkelsen, Tom, Carlotti, Carlos G., Kalkanis, Steven, Zenklusen, Jean, Salama, Sofie R., Barnholtz-Sloan, Jill S., Noushmehr, Houtan

“…Glioma diagnosis is based on histomorphology and grading; however, such classification does not have predictive clinical outcome after glioblastomas have…”
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CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study by Yadav, Viveka Nand, Zamler, Daniel, Baker, Gregory J, Kadiyala, Padma, Erdreich-Epstein, Anat, DeCarvalho, Ana C, Mikkelsen, Tom, Castro, Maria G, Lowenstein, Pedro R

“…Glioblastoma (GBM) is a highly invasive brain tumor. Perivascular invasion, autovascularization and vascular co-option occur throughout the disease and lead to…”
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Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles by Lubanska, Dorota, Alrashed, Sami, Mason, Gage T., Nadeem, Fatima, Awada, Angela, DiPasquale, Mitchell, Sorge, Alexandra, Malik, Aleena, Kojic, Monika, Soliman, Mohamed A. R., deCarvalho, Ana C., Shamisa, Abdalla, Kulkarni, Swati, Marquardt, Drew, Porter, Lisa A., Rondeau-Gagné, Simon

“…Glioblastoma is one of the most aggressive types of cancer with success of therapy being hampered by the existence of treatment resistant populations of…”
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Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model by Kim, Bryan D, Mondal, Sujan K, Kenyon, Elizabeth, Chen, Ming, Mallett, Christiane L, deCarvalho, Ana C, Medarova, Zdravka, Moore, Anna

“…Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain malignancy for which there is no cure. The blood-brain barrier is a…”
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The Cyclin-like Protein Spy1 Regulates Growth and Division Characteristics of the CD133+ Population in Human Glioma by Lubanska, Dorota, Market-Velker, Brenna A., deCarvalho, Ana C., Mikkelsen, Tom, Fidalgo da Silva, Elizabeth, Porter, Lisa A.

“…The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving…”
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Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors by Herrgott, Grayson A, Asmaro, Karam P, Wells, Michael, Sabedot, Thais S, Malta, Tathiane M, Mosella, Maritza S, Nelson, Kevin, Scarpace, Lisa, Barnholtz-Sloan, Jill S, Sloan, Andrew E, Selman, Warren R, deCarvalho, Ana C, Poisson, Laila M, Mukherjee, Abir, Robin, Adam M, Lee, Ian Y, Snyder, James, Walbert, Tobias, Rosenblum, Mark, Mikkelsen, Tom, Bhan, Arti, Craig, John, Kalkanis, Steven, Rock, Jack, Noushmehr, Houtan, Castro, Ana Valeria

“…Abstract Background DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations…”
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DNA methylation-based signatures classify sporadic pituitary tumors according to clinicopathological features by Mosella, Maritza S, Sabedot, Thais S, Silva, Tiago C, Malta, Tathiane M, Dezem, Felipe Segato, Asmaro, Karam P, Wells, Michael, Mukherjee, Abir, Poisson, Laila M, Snyder, James, deCarvalho, Ana C, Walbert, Tobias, Aho, Todd, Kalkanis, Steven, Elias, Paula C, Antonini, Sonir R, Rock, Jack, Noushmehr, Houtan, Castro, Margaret, Castro, Ana Valeria

“…Abstract Background Distinct genome-wide methylation patterns cluster pituitary neuroendocrine tumors (PitNETs) into molecular groups associated with specific…”
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Glioblastoma Cell Enrichment Is Critical for Analysis of Phosphorylated Drug Targets and Proteomic-Genomic Correlations by MUELLER, Claudius, DECARVALHO, Ana C, MIKKELSEN, Tom, LEHMAN, Norman L, CALVERT, Valerie, ESPINA, Virginia, LIOTTA, Lance A, PETRICOIN, Emanuel F

“…The quality of cancer genomic and proteomic data relies upon the quality of the clinical specimens examined. Here, we show that data derived from…”
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Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery by Ye, Ling F, Reznik, Eduard, Korn, Joshua M, Lin, Fallon, Yang, Guizhi, Malesky, Kimberly, Gao, Hui, Loo, Alice, Pagliarini, Raymond, Mikkelsen, Tom, Lo, Donald C, deCarvalho, Ana C, Stockwell, Brent R

“…There is a compelling need for new therapeutic strategies for glioblastoma multiforme (GBM). Preclinical target and therapeutic discovery for GBMs is primarily…”
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