Search Results - "DeCaen, Paul"

Primary cilia are specialized calcium signalling organelles by Delling, Markus, DeCaen, Paul G., Doerner, Julia F., Febvay, Sebastien, Clapham, David E.

“…Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of…”
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Direct recording and molecular identification of the calcium channel of primary cilia by DeCaen, Paul G., Delling, Markus, Vien, Thuy N., Clapham, David E.

“…Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of…”
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Polycystin Channel Complexes by Esarte Palomero, Orhi, Larmore, Megan, DeCaen, Paul G

“…Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels…”
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The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs by Shen, Peter S., Yang, Xiaoyong, DeCaen, Paul G., Liu, Xiaowen, Bulkley, David, Clapham, David E., Cao, Erhu

“…The Polycystic Kidney Disease 2 (Pkd2) gene is mutated in autosomal dominant polycystic kidney disease (ADPKD), one of the most common human monogenic…”
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The complete structure of an activated open sodium channel by Sula, Altin, Booker, Jennifer, Ng, Leo C. T., Naylor, Claire E., DeCaen, Paul G., Wallace, B. A.

“…Voltage-gated sodium channels (Navs) play essential roles in excitable tissues, with their activation and opening resulting in the initial phase of the action…”
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Primary cilia TRP channel regulates hippocampal excitability by Vien, Thuy N, Ta, My C, Kimura, Louise F, Onay, Tuncer, DeCaen, Paul G

“…Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2…”
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Primary cilia TRP channels regulate hippocampal excitability by Vien, Thuy, Ta, My C., DeCaen, Paul G.

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TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles by Abiria, Sunday A., Krapivinsky, Grigory, Sah, Rajan, Santa-Cruz, Ana G., Chaudhuri, Dipayan, Zhang, Jin, Adstamongkonkul, Pichet, DeCaen, Paul G., Clapham, David E.

“…TRPM7 (transient receptor potential cation channel subfamily M member 7) regulates gene expression and stress-induced cytotoxicity and is required in early…”
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Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium by Liu, Xiaowen, Vien, Thuy, Duan, Jingjing, Sheu, Shu-Hsien, DeCaen, Paul G, Clapham, David E

“…Mutations in the polycystin genes, or results in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Although a genetic basis of ADPKD is established, we…”
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Molecular basis of ion permeability in a voltage-gated sodium channel by Naylor, Claire E, Bagnéris, Claire, DeCaen, Paul G, Sula, Altin, Scaglione, Antonella, Clapham, David E, Wallace, BA

“…Voltage‐gated sodium channels are essential for electrical signalling across cell membranes. They exhibit strong selectivities for sodium ions over other…”
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Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel by Zhang, Xu, Ren, Wenlin, DeCaen, Paul, Yan, Chuangye, Tao, Xiao, Tang, Lin, Wang, Jingjing, Hasegawa, Kazuya, Kumasaka, Takashi, He, Jianhua, Wang, Jiawei, Clapham, David E., Yan, Nieng

“…The crystal structure of Na v Rh, a NaChBac orthologue from the marine Rickettsiales sp. HIMB114 , defines an ion binding site within the selectivity filter,…”
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Structural basis for gating charge movement in the voltage sensor of a sodium channel by Yarov-Yarovoy, Vladimir, DeCaen, Paul G, Westenbroek, Ruth E, Pan, Chien-Yuan, Scheuer, Todd, Baker, David, Catterall, William A

“…Voltage-dependent gating of ion channels is essential for electrical signaling in excitable cells, but the structural basis for voltage sensor function is…”
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A synthetic approach to yugO K+ channel biophysics by Larmore, Megan, Esarte Polomero, Orhi, Kamat, Neha P., DeCaen, Paul G.

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William A. Catterall (1946-2024) by Scheuer, Todd, Westenbroek, Ruth, Zheng, Ning, Kalume, Franck, Vien, Thuy N, Payandeh, Jian, DeCaen, Paul G

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Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism by Bagnéris, Claire, DeCaen, Paul G., Naylor, Claire E., Pryde, David C., Nobeli, Irene, Clapham, David E., Wallace, B. A.

“…Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms…”
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Progress in ciliary ion channel physiology by Pablo, Juan Lorenzo, DeCaen, Paul G, Clapham, David E

“…Mammalian cilia are ubiquitous appendages found on the apical surface of cells. Primary and motile cilia are distinct in both morphology and function. Most…”
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Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel by Ulmschneider, Martin B., Bagnéris, Claire, McCusker, Emily C., DeCaen, Paul G., Delling, Markus, Clapham, David E., Ulmschneider, Jakob P., Wallace, B. A.

“…The crystal structure of the open conformation of a bacterial voltage-gated sodium channel pore from Magnetococcus sp . (NaVMs) has provided the basis for a…”
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A tamoxifen receptor within a voltage-gated sodium channel by Sula, Altin, Hollingworth, David, Ng, Leo C.T., Larmore, Megan, DeCaen, Paul G., Wallace, B.A.

“…Voltage-gated sodium channels are targets for many analgesic and antiepileptic drugs whose therapeutic mechanisms and binding sites have been well…”
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Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain by Vien, Thuy N., Wang, Jinliang, Ng, Leo C. T., Cao, Erhu, DeCaen, Paul G.

“…Genetic variants in PKD2 which encodes for the polycystin-2 ion channel are responsible for many clinical cases of autosomal dominant polycystic kidney disease…”
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Gating charge interactions with the S1 segment during activation of a Na+ channel voltage sensor by DeCaen, Paul G, Yarov-Yarovoy, Vladimir, Scheuer, Todd, Catterall, William A

“…Voltage-gated Na+ channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion…”
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