Search Results - "DeBerg, Hannah A"

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy by Sheih, Alyssa, Voillet, Valentin, Hanafi, Laïla-Aïcha, DeBerg, Hannah A., Yajima, Masanao, Hawkins, Reed, Gersuk, Vivian, Riddell, Stanley R., Maloney, David G., Wohlfahrt, Martin E., Pande, Dnyanada, Enstrom, Mark R., Kiem, Hans-Peter, Adair, Jennifer E., Gottardo, Raphaël, Linsley, Peter S., Turtle, Cameron J.

“…Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and…”
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Double electron–electron resonance reveals cAMP-induced conformational change in HCN channels by Puljung, Michael C., DeBerg, Hannah A., Zagotta, William N., Stoll, Stefan

“…Binding of 3′,5′-cyclic adenosine monophosphate (cAMP) to hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels regulates their gating. cAMP…”
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Rates and equilibrium constants of the ligand-induced conformational transition of an HCN ion channel protein domain determined by DEER spectroscopy by Collauto, Alberto, DeBerg, Hannah A, Kaufmann, Royi, Zagotta, William N, Stoll, Stefan, Goldfarb, Daniella

“…Ligand binding can induce significant conformational changes in proteins. The mechanism of this process couples equilibria associated with the ligand binding…”
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Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel by Wang, Yong, Liu, Yanxin, Deberg, Hannah A, Nomura, Takeshi, Hoffman, Melinda Tonks, Rohde, Paul R, Schulten, Klaus, Martinac, Boris, Selvin, Paul R

“…The mechanosensitive channel of large conductance, which serves as a model system for mechanosensitive channels, has previously been crystallized in the closed…”
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Incidence of Skin and Respiratory Immune-Related Adverse Events Correlates With Specific Tumor Types in Patients Treated With Checkpoint Inhibitors by Rose, Lynn M, DeBerg, Hannah A, Vishnu, Prakash, Frankel, Jason K, Manjunath, Adarsh B, Flores, John Paul E, Aboulafia, David M

“…Checkpoint inhibitors (CPIs) increase antitumor activity by unblocking regulators of the immune response. This action can provoke a wide range of immunologic…”
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Single-cell census of mechanosensitive channels in living bacteria by Bialecka-Fornal, Maja, Lee, Heun Jin, DeBerg, Hannah A, Gandhi, Chris S, Phillips, Rob

“…Bacteria are subjected to a host of different environmental stresses. One such insult occurs when cells encounter changes in the osmolarity of the surrounding…”
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Structural Mechanism for the Regulation of HCN Ion Channels by the Accessory Protein TRIP8b by DeBerg, Hannah A., Bankston, John R., Rosenbaum, Joel C., Brzovic, Peter S., Zagotta, William N., Stoll, Stefan

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels underlie the cationic Ih current present in many neurons. The direct binding of cyclic…”
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Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling by DeBerg, Hannah A, Zaidi, Mussaret B, Altman, Matthew C, Khaenam, Prasong, Gersuk, Vivian H, Campos, Freddy D, Perez-Martinez, Iza, Meza-Segura, Mario, Chaussabel, Damien, Banchereau, Jacques, Estrada-Garcia, Teresa, Linsley, Peter S

“…Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who…”
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Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes by Balmas, Elisa, Chen, Janice, Hu, Alex K, DeBerg, Hannah A, Rosasco, Mario G, Gersuk, Vivian H, Serti, Elisavet, Speake, Cate, Greenbaum, Carla J, Nepom, Gerald T, Linsley, Peter S, Cerosaletti, Karen

“…Variation in the preservation of β cell function in clinical trials in type 1 diabetes (T1D) has emphasized the need to define biomarkers to predict treatment…”
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Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes by Linsley, Peter S, Barahmand-Pour-Whitman, Fariba, Balmas, Elisa, DeBerg, Hannah A, Flynn, Kaitlin J, Hu, Alex K, Rosasco, Mario G, Chen, Janice, O'Rourke, Colin, Serti, Elisavet, Gersuk, Vivian H, Motwani, Keshav, Seay, Howard R, Brusko, Todd M, Kwok, William W, Speake, Cate, Greenbaum, Carla J, Nepom, Gerald T, Cerosaletti, Karen

“…Human islet antigen reactive CD4+ memory T cells (IAR T cells) play a key role in the pathogenesis of autoimmune type 1 diabetes (T1D). Using single-cell RNA…”
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Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells by Berkson, Julia D, Slichter, Chloe K, DeBerg, Hannah A, Delaney, Martha A, Woodward-Davis, Amanda S, Maurice, Nicholas J, Lwo, Yu, Ko, Alex, Hsu, Jessica, Chiu, Yu-Wen, Linsley, Peter S, Dixon, Douglas, Prlic, Martin

“…Mucosal-associated invariant T (MAIT) cells acquire effector function in response to proinflammatory signals, which synergize with TCR-mediated signals. We…”
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Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression by Wiedeman, Alice E, Muir, Virginia S, Rosasco, Mario G, DeBerg, Hannah A, Presnell, Scott, Haas, Bertrand, Dufort, Matthew J, Speake, Cate, Greenbaum, Carla J, Serti, Elisavet, Nepom, Gerald T, Blahnik, Gabriele, Kus, Anna M, James, Eddie A, Linsley, Peter S, Long, S Alice

“…Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell…”
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Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b by Bankston, John R., DeBerg, Hannah A., Stoll, Stefan, Zagotta, William N.

“…TRIP8b, an accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels, alters both the cell surface expression and cyclic…”
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Safety and immunopharmacology of ASP0892 in adults or adolescents with peanut allergy: two randomized trials by Ferslew, Brian C., Smulders, Ronald, Zhu, Tong, Blauwet, Mary B., Kusawake, Tomohiro, Spence, Anna, Aldridge, Kelly, DeBerg, Hannah A., Khosa, Sugandhika, Wambre, Erik, Chichili, Gurunadh R.

“…Background New treatment options with improved safety and novel mechanisms of actions are needed for patients with peanut allergy. Objectives To evaluate the…”
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Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells by Mouri, Kousuke, Guo, Michael H., de Boer, Carl G., Lissner, Michelle M., Harten, Ingrid A., Newby, Gregory A., DeBerg, Hannah A., Platt, Winona F., Gentili, Matteo, Liu, David R., Campbell, Daniel J., Hacohen, Nir, Tewhey, Ryan, Ray, John P.

“…Genome-wide association studies (GWASs) have uncovered hundreds of autoimmune disease-associated loci; however, the causal genetic variants within each locus…”
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Oral desensitization therapy for peanut allergy induces dynamic changes in peanut‐specific immune responses by Bajzik, Veronique, DeBerg, Hannah A., Garabatos, Nahir, Rust, Blake J., Obrien, Kimberly K., Nguyen, Quynh‐Anh, O’Rourke, Colin, Smith, Alex, Walker, Alex H., Quinn, Charlie, Gersuk, Vivian H., Farrington, Mary, Jeong, David, Vickery, Brian P., Adelman, Daniel C., Wambre, Erik

“…Background The PALISADE study, an international, phase 3 trial of peanut oral immunotherapy (POIT) with AR101, resulted in desensitization in children and…”
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Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides by DeBerg, Hannah A., Brzovic, Peter S., Flynn, Galen E., Zagotta, William N., Stoll, Stefan

“…Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain. They…”
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Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy by Voskamp, Astrid L., Khosa, Sugandhika, Phan, Tracy, DeBerg, Hannah A., Bingham, Judy, Hew, Mark, Smith, William, Abramovitch, Jodie, Rolland, Jennifer M., Moyle, Matthew, Nadeau, Kari C., Lack, Gideon, Larché, Mark, Wambre, Erik, O'Hehir, Robyn E., Hickey, Pascal, Prickett, Sara R.

“…Background Food allergy is a leading cause of anaphylaxis worldwide. Allergen‐specific immunotherapy is the only treatment shown to modify the natural history…”
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An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy by Jamison, Braxton L., Lawrance, Matthew, Wang, Chun Jing, DeBerg, Hannah A., Ziegler, Lauren J., Sansom, David M., Gavin, Marc A., Walker, Lucy S.K., Campbell, Daniel J.

“…Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3+ regulatory T (TR) cells are in clinical trials for treating…”
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Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4 + T Cells in Peripheral Blood of Subjects with Type 1 Diabetes by Cerosaletti, Karen, Barahmand-Pour-Whitman, Fariba, Yang, Junbao, DeBerg, Hannah A, Dufort, Matthew J, Murray, Sara A, Israelsson, Elisabeth, Speake, Cate, Gersuk, Vivian H, Eddy, James A, Reijonen, Helena, Greenbaum, Carla J, Kwok, William W, Wambre, Erik, Prlic, Martin, Gottardo, Raphael, Nepom, Gerald T, Linsley, Peter S

“…The significance of islet Ag-reactive T cells found in peripheral blood of type 1 diabetes (T1D) subjects is unclear, partly because similar cells are also…”
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