Search Results - "DeBell, Karen E."

Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane by Hao, Jian-Jiang, Liu, Yin, Kruhlak, Michael, Debell, Karen E, Rellahan, Barbara L, Shaw, Stephen

“…Mechanisms controlling the disassembly of ezrin/radixin/moesin (ERM) proteins, which link the cytoskeleton to the plasma membrane, are incompletely understood…”
Get full text

Functional requirements for inhibitory signal transmission by the immunomodulatory receptor CD300a by DeBell, Karen E, Simhadri, Venkateswara R, Mariano, John L, Borrego, Francisco

“…Activation signals can be negatively regulated by cell surface receptors bearing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD300a, an ITIM…”
Get full text

Differential expression of CD300a/c on human TH1 and TH17 cells by Simhadri, Venkateswara R, Mariano, John L, Zhou, Qing, DeBell, Karen E, Borrego, Francisco

“…Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (T(EM)) cells are mostly CD300a/c+,…”
Get full text

Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes by Verı́, Maria-Concetta, DeBell, Karen E., Seminario, Maria-Cristina, DiBaldassarre, Angela, Reischl, Ilona, Rawat, Rashmi, Graham, Laurie, Noviello, Cristiana, Rellahan, Barbara L., Miscia, Sebastiano, Wange, Ronald L., Bonvini, Ezio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A dynamic constitutive and inducible binding of c-Cbl by PLCγ1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCγ1 activation in lymphocytes by Rellahan, Barbara L, Graham, Laurie J, Tysgankov, Alexander Y, DeBell, Karen E, Veri, Maria-Concetta, Noviello, Cristiana, Bonvini, Ezio

“…We investigated the structural requirements for c-Cbl-mediated inhibition of Ag receptor-induced PLCγ1 activation. Analysis of site-specific c-Cbl mutants…”
Get full text

Functional Independence and Interdependence of the Src Homology Domains of Phospholipase C-γ1 in B-Cell Receptor Signal Transduction by DeBell, Karen E., Stoica, Bogdan A., Verí, Maria-Concetta, Di Baldassarre, Angela, Miscia, Sebastiano, Graham, Laurie J., Rellahan, Barbara L., Ishiai, Masamichi, Kurosaki, Tomohiro, Bonvini, Ezio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

70Z/3 Cbl induces PLCγ1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism by GRAHAM, Laurie J, VERI, Maria-Concetta, DEBELL, Karen E, NOVIELLO, Cristiana, RAWAT, Rashmi, JEN, Sandy, BONVINI, Ezio, RELLAHAN, Barbara

“…The oncoprotein 70Z/3 Cbl signals in an autonomous fashion or through blockade of endogenous c-Cbl, a negative regulator of signaling. The mechanism of 70Z/3…”
Get full text

Cbl-mediated Regulation of T Cell Receptor-induced AP1 Activation by Rellahan, Barbara L., Graham, Laurie J., Stoica, Bogdan, DeBell, Karen E., Bonvini, Ezio

“…The functional role of Cbl in regulating T cell receptor (TCR)-mediated signal transduction pathways is unknown. This study uses Cbl overexpression in…”
Get full text

Phospholipase C–mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane by Hao, Jian-Jiang, Liu, Yin, Kruhlak, Michael, Debell, Karen E., Rellahan, Barbara L., Shaw, Stephen

Get full text

Differential expression of CD300a/c on human T.sub.H 1 and T.sub.H 17 cells by Simhadri, Venkateswara R, Mariano, John L, Zhou, Qing, DeBell, Karen E, Borrego, Francisco

“…Human memory CD4.sup.+ .sup.T cells can be either CD300a/c.sup.+ .sup.or CD300a/c.sup.- .sup.and subsequent analyses showed that CD4.sup.+ .sup.effector memory…”
Get full text

On the mechanism coupling phospholipase Cγ1 to the B- and T-cell antigen receptors by Bonvini, Ezio, DeBell, Karen E, Verı́, Maria-Concetta, Graham, Laurie, Stoica, Bogdan, Laborda, Jorge, Aman, M.Javad, DiBaldassarre, Angela, Miscia, Sebastiano, Rellahan, Barbara L

Get full text

Differential expression of CD300a/c on human TH 1 and TH 17 cells by Simhadri, Venkateswara R, Mariano, John L, Zhou, Qing, DeBell, Karen E, Borrego, Francisco

“…Abstract Background: Human memory CD4+ T cells can be either CD300a/c+ or CD300a/c- and subsequent analyses showed that CD4+ effector memory T (TEM ) cells are…”
Get full text

The Amino-Terminal Src Homology 2 Domain of Phospholipase Cγ1 Is Essential for TCR-Induced Tyrosine Phosphorylation of Phospholipase Cγ1 by Stoica, Bogdan, DeBell, Karen E., Graham, Laurie, Rellahan, Barbara L., Alava, Maria A., Laborda, Jorge, Bonvini, Ezio

“…TCR engagement activates phospholipase Cγ1 (PLCγ1) via a tyrosine phosphorylation-dependent mechanism. PLCγ1 contains a pair of Src homology 2 (SH2) domains…”
Get full text

Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway by Rellahan, B L, Graham, L J, Stoica, B, DeBell, K E, Bonvini, E

“…The functional role of Cbl in regulating T cell receptor (TCR)-mediated signal transduction pathways is unknown. This study uses Cbl overexpression in…”
Get full text

A dynamic constitutive and inducible binding of c-Cbl by PLCgamma1 SH3 and SH2 domains (negatively) regulates antigen receptor-induced PLCgamma1 activation in lymphocytes by Rellahan, Barbara L, Graham, Laurie J, Tysgankov, Alexander Y, DeBell, Karen E, Veri, Maria-Concetta, Noviello, Cristiana, Bonvini, Ezio

“…We investigated the structural requirements for c-Cbl-mediated inhibition of Ag receptor-induced PLCgamma1 activation. Analysis of site-specific c-Cbl mutants…”
Get full text

70Z 3 Cbl induces PLC 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism by Graham, Laurie J, Maria-Concetta Verí, DeBell, Karen E, Noviello, Cristiana, Rawat, Rashmi, Jen, Sandy, Bonvini, Ezio, Rellahan, Barbara

“…The oncoprotein 70Z/3 Cbl signals in an autonomous fashion or through blockade of endogenous c-Cbl, a negative regulator of signaling. The mechanism of 70Z/3…”
Get full text

70Z/3 Cbl induces PLC gamma 1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism by Graham, Laurie J, Verí, Maria-Concetta, DeBell, Karen E, Noviello, Cristiana, Rawat, Rashmi, Jen, Sandy, Bonvini, Ezio, Rellahan, Barbara

“…The oncoprotein 70Z/3 Cbl signals in an autonomous fashion or through blockade of endogenous c-Cbl, a negative regulator of signaling. The mechanism of 70Z/3…”
Get full text

Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cγ-1 activity by Graham, Laurie J., DeBell, Karen E., Verı́, Maria-Concetta, Stoica, Bogdan, Mostowski, Howard, Bonvini, Ezio, Rellahan, Barbara

“…We demonstrate that the differential effects Cbl and oncogenic 70Z/3 Cbl have on Ca 2+/Ras-sensitive NF-AT reporters is partially due to their opposing ability…”
Get full text

Sequences Surrounding the Src-Homology 3 Domain of Phospholipase Cγ-1 Increase the Domain's Association with Cbl by Graham, Laurie J., Stoica, Bogdan A., Shapiro, Marjorie, DeBell, Karen E., Rellahan, Barbara, Laborda, Jorge, Bonvini, Ezio

“…SH3 domains are protein modules that interact with proline-rich polypeptide fragments. Cbl is an adapter-like protein known to interact with several SH3…”
Get full text

Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes by DeBell, KE, Conti, A, Alava, MA, Hoffman, T, Bonvini, E

“…Cytoskeletal involvement in the response to TCR/CD3 ligation and in signal transduction was investigated in a murine Th cell type 2 clone. Cells coated with…”
Get full text