Search Results - "DeAngelis, Paul L"

Nanoparticle Toxicology by Yang, Wen, Wang, Lin, Mettenbrink, Evan M, DeAngelis, Paul L, Wilhelm, Stefan

“…Nanoparticles from natural and anthropogenic sources are abundant in the environment, thus human exposure to nanoparticles is inevitable. Due to this constant…”
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Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases by Weigel, Paul H., DeAngelis, Paul L.

“…Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two…”
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Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores by Rivas, Felipe, DeAngelis, Paul L., Rahbar, Elaheh, Hall, Adam R.

“…Hyaluronan (HA) is an essential carbohydrate in vertebrates that is a potentially robust bioindicator due to its critical roles in diverse physiological…”
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Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor by Rivas, Felipe, Zahid, Osama K., Reesink, Heidi L., Peal, Bridgette T., Nixon, Alan J., DeAngelis, Paul L., Skardal, Aleksander, Rahbar, Elaheh, Hall, Adam R.

“…Hyaluronan (or hyaluronic acid, HA) is a ubiquitous molecule that plays critical roles in numerous physiological functions in vivo, including tissue hydration,…”
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Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors by He, Peng, Zhang, Xing, Xia, Ke, Green, Dixy E., Baytas, Sultan, Xu, Yongmei, Pham, Truong, Liu, Jian, Zhang, Fuming, Almond, Andrew, Linhardt, Robert J., DeAngelis, Paul L.

“…Complex carbohydrates (glycans) are major players in all organisms due to their structural, energy, and communication roles. This last essential role involves…”
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Methods for isolating and analyzing physiological hyaluronan: a review by Rivas, Felipe, Erxleben, Dorothea, Smith, Ian, Rahbar, Elaheh, DeAngelis, Paul L, Cowman, Mary K, Hall, Adam R

“…The carbohydrate hyaluronan (or hyaluronic acid, HA) is found in all human tissues and biofluids where it has wide-ranging functions in health and disease that…”
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Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c by Schultz, Victor, Suflita, Mathew, Liu, Xinyue, Zhang, Xing, Yu, Yanlei, Li, Lingyun, Green, Dixy E., Xu, Yongmei, Zhang, Fuming, DeAngelis, Paul L., Liu, Jian, Linhardt, Robert J.

“…A small library of well defined heparan sulfate (HS) polysaccharides was chemoenzymatically synthesized and used for a detailed structure-activity study of…”
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A quartz crystal microbalance method to quantify the size of hyaluronan and other glycosaminoglycans on surfaces by Srimasorn, Sumitra, Souter, Luke, Green, Dixy E., Djerbal, Lynda, Goodenough, Ashleigh, Duncan, James A., Roberts, Abigail R. E., Zhang, Xiaoli, Débarre, Delphine, DeAngelis, Paul L., Kwok, Jessica C. F., Richter, Ralf P.

“…Hyaluronan (HA) is a major component of peri- and extra-cellular matrices and plays important roles in many biological processes such as cell adhesion,…”
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Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation by Fasanello, Diana C, Su, Jin, Deng, Siyu, Yin, Rose, Colville, Marshall J, Berenson, Joshua M, Kelly, Carolyn M, Freer, Heather, Rollins, Alicia, Wagner, Bettina, Rivas, Felipe, Hall, Adam R, Rahbar, Elaheh, DeAngelis, Paul L, Paszek, Matthew J, Reesink, Heidi L

“…TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the…”
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CSPG4-dependent cytotoxicity for C. difficile TcdB is influenced by extracellular calcium and chondroitin sulfate by Doyle, D Annie, DeAngelis, Paul L, Ballard, Jimmy D

“…TcdB is an intracellular bacterial toxin indispensable to infections. The ability to use chondroitin sulfate proteoglycan 4 (CSPG4) as a primary cell surface…”
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Synchronized Chemoenzymatic Synthesis of Monodisperse Hyaluronan Polymers by Jing, Wei, DeAngelis, Paul L

“…The length of the hyaluronan (HA) polysaccharide chain dictates its biological effects in many cellular and tissue systems. Long and short HA polymers often…”
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Chemoenzymatic Synthesis of Uridine Diphosphate-GlcNAc and Uridine Diphosphate-GalNAc Analogs for the Preparation of Unnatural Glycosaminoglycans by Masuko, Sayaka, Bera, Smritilekha, Green, Dixy E, Weïwer, Michel, Liu, Jian, DeAngelis, Paul L, Linhardt, Robert J

“…Eight N-acetylglucosamine-1-phosphate and N-acetylgalactosamine-1-phosphate analogs have been synthesized chemically and were tested for their recognition by…”
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Hyaluronic Acid Production in Bacillus subtilis by Widner, Bill, Behr, Régine, Von Dollen, Steve, Tang, Maria, Heu, Tia, Sloma, Alan, Sternberg, Dave, DeAngelis, Paul L, Weigel, Paul H, Brown, Steve

“…The hasA gene from Streptococcus equisimilis, which encodes the enzyme hyaluronan synthase, has been expressed in Bacillus subtilis, resulting in the…”
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Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow by DeAngelis, Paul L.

“…Glycosaminoglycans [GAGs] are essential heteropolysaccharides in vertebrate tissues that are also, in certain cases, employed as virulence factors by microbes…”
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Hyaluronan synthases; mechanisms, myths, & mysteries of three types of unique bifunctional glycosyltransferases by DeAngelis, Paul L, Zimmer, Jochen

“…Abstract Hyaluronan (HA), the essential [-3-GlcNAc-1-β-4-GlcA-1-β-]n matrix polysaccharide in vertebrates and molecular camouflage coating in select pathogens,…”
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Hyaluronan: the absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models by Blundell, Charles D, Deangelis, Paul L, Almond, Andrew

“…Contradictory descriptions for the aqueous solution conformation of the glycosaminoglycan hyaluronan (HA) exist in the literature. According to hydrodynamic…”
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A primer for initiation of commercialization of glycobiological discoveries by DeAngelis, Paul L

“…In this age of translational science, blossoming biotechnology and increasingly elusive federal funding, a working knowledge of commercialization beyond…”
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N-Sulfotestosteronan, A Novel Substrate for Heparan Sulfate 6-O-Sulfotransferases and its Analysis by Oxidative Degradation by Li, Guoyun, Masuko, Sayaka, Green, Dixy E., Xu, Yongmei, Li, Lingyun, Zhang, Fuming, Xue, Changhu, Liu, Jian, DeAngelis, Paul L., Linhardt, Robert J.

“…ABSTRACT Testosteronan, an unusual glycosaminoglycan (GAG) first isolated from the microbe Comamonas testosteroni, was enzymatically synthesized in vitro by…”
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Functional Characterization of PmHS1, a Pasteurella multocida Heparosan Synthase by Kane, Tasha A., White, Carissa L., DeAngelis, Paul L.

“…Heparosan synthase 1 (PmHS1) from Pasteurella multocida Type D is a dual action glycosyltransferase enzyme that transfers monosaccharide units from uridine…”
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Heparosan, a promising 'naturally good' polymeric conjugating vehicle for delivery of injectable therapeutics by DeAngelis, Paul L

“…Many therapeutics have issues with delivery due to nonoptimal pharmacokinetics and/or detrimental side effects due to their nonhuman nature. Injectable…”
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