Search Results - "DeAizpurua, H J"

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells by JIANG, F.-X, CRAM, D. S, DEAIZPURUA, H. J, HARRISON, L. C

“…Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells. F X Jiang , D S Cram , H J DeAizpurua and L C Harrison Autoimmunity and…”
Get full text

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes by Harrison, L C, Honeyman, M C, DeAizpurua, H J, Schmidli, R S, Colman, P G, Tait, B D, Cram, D S

“…Glutamic acid decarboxylase (GAD) in pancreatic beta cells is an autoantigen in insulin-dependent diabetes (IDD). We measured immunity to GAD in 31…”
Get more information

An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM by DeAizpurua, H. J., Harrison, L. C., Cram, D. S.

“…An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM. H J DeAizpurua , L C Harrison and D S Cram Burnet Clinical Research Unit, Walter…”
Get full text

Differential mRNA display analysis of two related but functionally distinct rat insulinoma (RIN) cell lines: identification of CD24 and its expression in the developing pancreas by Cram, David S., McIntosh, Annette, Oxbrow, Leonie, Johnston, Anne M., DeAizpurua, Henry J.

“…To identify genes that might play a role in growth and differentiation of pancreatic β-cells, we have applied the technique of differential mRNA display to the…”
Get full text

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway by JOHNSTON, Anne M, NASELLI, Gaetano, GONEZ, L. Jorge, MARTIN, Roland M, HARRISON, Leonard C, DEAIZPURUA, Henry J

“…We have cloned a member of the STE20/SPS1 protein kinase family from a transformed rat pancreatic beta cell line. SPAK (STE20/SPS1-related, proline…”
Get full text

Antibodies to glutamic acid decarboxylase in at-risk and clinical insulin-dependent diabetic subjects: relationship to age, sex and islet cell antibody status, and temporal profile by Schmidli, R S, DeAizpurua, H J, Harrison, L C, Colman, P G

“…Antibodies to glutamic decarboxylase (GADAb) are present in insulin-dependent diabetes (IDD) but their association with age and sex and their temporal profile…”
Get more information

Antibodies to the Protein Tyrosine Phosphatases IAR and IA-2 are Associated with Progression to Insulin-Dependent Diabetes (IDDM) in First-Degree Relatives At-Risk for IDDM by Schmidli, Robert S., Colman, Peter G., Cui, Lin, Yu, Wei-Ping, Kewming, Kim, Jankulovski, Connie, Harrison, Leonard C., Pallen, Catherine J., Deaizpurua, Henry J.

“…Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP)…”
Get full text

Cloning and Characterization of Islet Cell Antigen-related Protein-tyrosine Phosphatase (PTP), a Novel Receptor-like PTP and Autoantigen in Insulin-dependent Diabetes by Cui, L, Yu, W P, DeAizpurua, H J, Schmidli, R S, Pallen, C J

“…Cloning of the cDNA encoding a novel human protein- tyrosine phosphatase (PTP) called islet cell antigen-related PTP (IAR) predicts a receptor-like molecule…”
Get full text

An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM by DEAIZPURUA, H. J, HARRISON, L. C, CRAM, D. S

“…To detect serum antibodies to GAD in subjects with IDDM, three recombinant mBGAD 67 peptides encompassing the full-length protein were used in an ELISA. In…”
Get full text

Expression of Mixed Lineage Kinase-1 in Pancreatic β-Cell Lines at Different Stages of Maturation and during Embryonic Pancreas Development by DeAizpurua, Henry J., Cram, David S., Naselli, Gaetano, Devereux, Lisa, Dorow, Donna S.

“…Events controlling differentiation to insulin-secreting β-cells in the pancreas are not well understood, although β-cells are thought to arise from pluripotent…”
Get full text

A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes by DeAizpurua, H J, Honeyman, M C, Harrison, L C

“…The development of insulin-dependent diabetes mellitus (IDDM) is associated with circulating antibodies to a pancreatic islet protein of MW 64,000 (64 kDa),…”
Get more information

Lack of expression of Gp-130 makes pancreatic beta cell lines unresponsive to the IL-6 family of cytokines by Naselli, G, Deaizpurua, H J, Thomas, H E, Johnston, A M, Kay, T W

“…Cytokine receptors from the IL-6 receptor family are comprised of ligand specific alpha chains and a common signalling chain, gp-130, which is also required…”
Get full text

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes by HARRISON, L. C, CHU, S. X, DEAIZPURUA, H.J, GRAHAML, M, HONEYMAN, M. C, COLMAN, P. G

“…The destruction of pancreatic islet beta cells in insulin-dependent diabetes mellitus (IDDM) is thought to be T cell mediated. To directly identify…”
Get full text

Glutamic acid decarboxylase in insulin-dependent diabetes mellitus by DeAizpurua, H J, Harrison, L C

Get more information

Cytokine regulation of glutamate decarboxylase biosynthesis in isolated rat islets of Langerhans by Schmidli, R S, Faulkner-Jones, B E, Harrison, L C, James, R F, DeAizpurua, H J

“…Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease in which cytokines are thought to play an important role in beta-cell destruction and…”
Get full text

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes by Atkinson, M, Leslie, D R

Get full text

Identification of pancreatic beta cell-related genes by representational difference analysis by Niwa, H, Harrison, L C, DeAizpurua, H J, Cram, D S

“…A knowledge of beta cell-specific gene expression provides a basis for identifying proteins potentially involved in beta cell function and pathology. To…”
Get full text

Oral vaccination: identification of classes of proteins that provoke an immune response upon oral feeding by DE AIZPURUA, H. J, RUSSELL-JONES, G. J

“…Oral immunization of an animal is generally hard to achieve unless large quantities of antigen are administered. In this study a number of antigens were tested…”
Get full text

Glutamic Acid Decarboxylase Autoantibodies in Preclinical Insulin-Dependent Diabetes by De Aizpurua, Henry J., Wilson, Yvette M., Harrison, Leonard C.

“…Insulin-dependent diabetes mellitus (IDDM) is associated with serum antibodies that precipitate a 64-kDa pancreatic islet cell protein reported to be glutamic…”
Get full text

Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies ω-conotoxin and adenosine by DE AIZPURUA, H. J, LAMBERT, E. H, GRIESMANN, G. E, OLIVERA, B. M, LENNON, V. A

“…The Lambert-Eaton myasthenic syndrome (LES) is an autoimmune presynaptic disorder of peripheral cholinergic neurotransmission in which there is often an…”
Get full text