Increased Activity of the Mg2+/Na+ Exchanger in Red Blood Cells From Essential Hypertensive Patients

Increased Activity of the Mg2+/Na+ Exchanger in Red Blood Cells From Essential Hypertensive Patients

Epidemiological, clinical, and experimental evidence suggests a relation between Mg metabolism and essential hypertension. The aim of the present study was the detection of abnormalities of the erythrocyte Mg/Na exchanger in essential hypertensive patients. We studied 66 untreated essential hyperten...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Vol. 23; no. 6, Part 2; pp. 987 - 991
Main Authors: Picado, María J, De la Siena, Alejandro, Aguilera, María T, Coca, Antonio, Urbano-Márquez, Alvaro
Format: Journal Article
Language:English
Published: Philadelphia, PA American Heart Association, Inc 01-06-1994
Hagerstown, MD Lippincott
Subjects:
Adult
Aged
Antiporters - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Erythrocytes - metabolism
Female
Humans
Hypertension - blood
Hypertension - physiopathology
Magnesium - blood
Male
Medical sciences
Middle Aged
Human
Hypertension
Blood cell
Pathophysiology
Sodium
Red blood cell
Ion transport
Cardiovascular disease
Magnesium
Ion exchange
Essential
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Summary:Epidemiological, clinical, and experimental evidence suggests a relation between Mg metabolism and essential hypertension. The aim of the present study was the detection of abnormalities of the erythrocyte Mg/Na exchanger in essential hypertensive patients. We studied 66 untreated essential hypertensive patients and 36 normotensive control subjects. Maximal efflux rates of total Mg efflux and the Na-dependent and Na-independent components of Mg efflux were determined in Mg-loaded red blood cells. Mg/Na exchanger was calculated as the Na-dependent component of the Mg efflux. Mean values of Mg/Na exchanger were clearly elevated in hypertensive subjects with respect to normotensive control subjects [184.7±15.7 versus 84.4±6 μmol(L · cell · h) P<.001]. This elevation was due primarily to the increased total Mg efflux [324.2±21.9 versus 257.9±17.3 μmol(L · cell · h); P<.05], whereas the Na-independent component was not significantly different between the groups [154.5±11.8 versus 173.4±15.5 μmol(L · cell · h); P=NS]. Moreover, total erythrocyte Mg content was slightly reduced in hypertensive patients with respect to normotensive control subjects (1.84±0.04 versus 2.07±0.04 mmol/L · cell; P<.001). Using the 99% confidence limits of the normotensive population as the normal range, 30 (45.5%) hypertensive subjects showed values of Mg/Na exchanger higher than 160 μmol(L · cell · h). The Mg/Na exchanger was inversely correlated with basal intraerythrocyte Mg content (r=−.323; P=.001). From a clinical point of view, we found a positive correlation between diastolic blood pressure values and Mg/N exchanger (r=.246; P<.05) in the sample of essential hypertensive patients. We conclude that erythrocyte Mg/Na exchanger is altered in 45% of essential hypertensive patients. This alteration could be responsible for the low basal intraerythrocyte Mg content observed in essential hypertension.
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content type line 23
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.23.6.987