Search Results - "De la O Becerra, Karla I."

Multifaceted Activities of Seven Nanobodies against Complement C4b by De la O Becerra, Karla I, Oosterheert, Wout, van den Bos, Ramon M, Xenaki, Katerina T, Lorent, Joseph H, Ruyken, Maartje, Schouten, Arie, Rooijakkers, Suzan H M, van Bergen En Henegouwen, Paul M P, Gros, Piet

“…Cleavage of the mammalian plasma protein C4 into C4b initiates opsonization, lysis, and clearance of microbes and damaged host cells by the classical and…”
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Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies by Struijf, Eva M., De la O Becerra, Karla I., Ruyken, Maartje, de Haas, Carla J.C., van Oosterom, Fleur, Siere, Danique Y., van Keulen, Joanne E., Heesterbeek, Dani A.C., Dolk, Edward, Heukers, Raimond, Bardoel, Bart W., Gros, Piet, Rooijakkers, Suzan H.M.

“…The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases. Since…”
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