Search Results - "De la Haba, Juan"

Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer by Toledano-Fonseca, Marta, Cano, M. Teresa, Inga, Elizabeth, Rodríguez-Alonso, Rosa, Gómez-España, M. Auxiliadora, Guil-Luna, Silvia, Mena-Osuna, Rafael, de la Haba-Rodríguez, Juan R., Rodríguez-Ariza, Antonio, Aranda, Enrique

“…Liquid biopsy may assist in the management of cancer patients, which can be particularly applicable in pancreatic ductal adenocarcinoma (PDAC). In this study,…”
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SWATH‐based proteomics reveals processes associated with immune evasion and metastasis in poor prognosis colorectal tumours by López‐Sánchez, Laura M., Jiménez‐Izquierdo, Rafael, Peñarando, Jon, Mena, Rafael, Guil‐Luna, Silvia, Toledano, Marta, Conde, Francisco, Villar, Carlos, Díaz, César, Ortea, Ignacio, De la Haba‐Rodríguez, Juan R., Aranda, Enrique, Rodríguez‐Ariza, Antonio

“…Newly emerged proteomic methodologies, particularly data‐independent acquisition (DIA) analysis–related approaches, would improve current gene expression–based…”
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Basal VEGF-A and ACE Plasma Levels of Metastatic Colorectal Cancer Patients Have Prognostic Value for First-Line Treatment with Chemotherapy Plus Bevacizumab by Ortiz-Morales, M. José, Toledano-Fonseca, Marta, Mena-Osuna, Rafael, Cano, M. Teresa, Gómez-España, Auxiliadora, Haba-Rodríguez, Juan R. De la, Rodríguez-Ariza, Antonio, Aranda, Enrique

“…The identification of factors that respond to anti-angiogenic therapy would represent a significant advance in the therapeutic management of…”
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CoCl2, a mimic of hypoxia, induces formation of polyploid giant cells with stem characteristics in colon cancer by Lopez-Sánchez, Laura M, Jimenez, Carla, Valverde, Araceli, Hernandez, Vanessa, Peñarando, Jon, Martinez, Antonio, Lopez-Pedrera, Chary, Muñoz-Castañeda, Juan R, De la Haba-Rodríguez, Juan R, Aranda, Enrique, Rodriguez-Ariza, Antonio

“…The induction of polyploidy is considered the reproductive end of cells, but there is evidence that polyploid giant cancer cells (PGCCs) contribute to cell…”
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Triple negative breast cancer subtypes and pathologic complete response rate to neoadjuvant chemotherapy by Santonja, Angela, Sánchez-Muñoz, Alfonso, Lluch, Ana, Chica-Parrado, Maria Rosario, Albanell, Joan, Chacón, José Ignacio, Antolín, Silvia, Jerez, José Manuel, de la Haba, Juan, de Luque, Vanessa, Fernández-De Sousa, Cristina Elisabeth, Vicioso, Luis, Plata, Yéssica, Ramírez-Tortosa, César Luis, Álvarez, Martina, Llácer, Casilda, Zarcos-Pedrinaci, Irene, Carrasco, Eva, Caballero, Rosalía, Martín, Miguel, Alba, Emilio

“…Triple negative breast cancer (TNBC) is a heterogeneous disease with distinct molecular subtypes that differentially respond to chemotherapy and targeted…”
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Nitric oxide-targeted therapy inhibits stemness and increases the efficacy of tamoxifen in estrogen receptor-positive breast cancer cells by López-Sánchez, Laura M., Mena, Rafael, Guil-Luna, Silvia, Mantrana, Ana, Peñarando, Jon, Toledano-Fonseca, Marta, Conde, Francisco, De la Haba-Rodríguez, Juan R., Aranda, Enrique, Rodríguez-Ariza, Antonio

“…Cancer stem cells (CSCs) are involved in the resistance of estrogen (ER)-positive breast tumors against endocrine therapy. On the other hand, nitric oxide (NO)…”
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Genetic variants in the renin-angiotensin system predict response to bevacizumab in cancer patients by Moreno-Muñoz, Diana, de la Haba-Rodríguez, Juan R., Conde, Francisco, López-Sánchez, Laura M., Valverde, Araceli, Hernández, Vanessa, Martínez, Antonio, Villar, Carlos, Gómez-España, Auxiliadora, Porras, Ignacio, Rodríguez-Ariza, Antonio, Aranda, Enrique

“…Background Currently, there are no predictive biomarkers for anti‐angiogenic strategies in cancer, but response to anti‐angiogenic drugs is associated with…”
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NeuroPredict: study of the predictive value of ABCB1 genetic polymorphisms and associated clinical factors in chronic chemotherapy-induced peripheral neuropathy (CIPN) by Vargas-Aliaga, Alicia, De la Haba, María, Contreras, María José, Morales Estevez, Cristina, Porras, Ignacio, Cano, María Teresa, Pulido, Gema, Gómez, María Auxiliadora, Flores-Paco, Pablo, Juan, De La Haba-Rodriguez, Aranda, Enrique

“…Chemotherapy-induced peripheral neuropathy (CIPN) is a common entity (30%-40%) and can significantly limit the quality of life of patients, especially those…”
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The role of CDK4/6 inhibitors in early breast cancer by Gil-Gil, Miguel, Alba, Emilio, Gavilá, Joaquín, de la Haba-Rodríguez, Juan, Ciruelos, Eva, Tolosa, Pablo, Candini, Daniele, Llombart-Cussac, Antonio

“…The use of cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) has proven to be a successful strategy in the treatment of advanced hormone receptor-positive (HR+)…”
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Clinical significance of glycogen synthase kinase 3 (GSK-3) expression and tumor budding grade in colorectal cancer: Implications for targeted therapy by Guil-Luna, Silvia, Rivas-Crespo, Aurora, Navarrete-Sirvent, Carmen, Mantrana, Ana, Pera, Alejandra, Mena-Osuna, Rafael, Toledano-Fonseca, Marta, García-Ortíz, María Victoria, Villar, Carlos, Sánchez-Montero, Maria Teresa, Krueger, Janna, Medina-Fernández, Francisco Javier, De La Haba-Rodríguez, Juan, Gómez-España, Auxiliadora, Aranda, Enrique, Rudd, Christopher E., Rodríguez-Ariza, Antonio

“…Glycogen synthase kinase 3 (GSK-3) has been proposed as a novel cancer target due to its regulating role in both tumor and immune cells. However, the…”
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A new updated prognostic index for patients with brain metastases (BMs) treated with palliative whole brain radiotherapy (WBRT) in the era of precision oncology. METASNCore project by Flores-Paco, Pablo, Vargas-Aliaga, Alicia, Guevara, María Geraldina, Lopera, Ignacio, Ruiz, Lucía Rodríguez, López-Herrero, María, Camús, Juan Adrián, López-González, Javier, Inga-Saavedra, Elizabeth, Montero, Marina, Barneto, Isidoro, Gómez-España, Mª Auxiliadora, Ruiz, Estela, Ruza, Marta, Armenta, Ana, Palacios, Amalia, De La Haba-Rodríguez, Juan R., Aranda, Enrique

“…Introduction Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive…”
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Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells by Valverde, Araceli, Peñarando, Jon, Cañas, Amanda, López-Sánchez, Laura M, Conde, Francisco, Hernández, Vanessa, Peralbo, Esther, López-Pedrera, Chary, de la Haba-Rodríguez, Juan, Aranda, Enrique, Rodríguez-Ariza, Antonio

“…Despite the demonstrated benefits of anti-EGFR/VEGF targeted therapies in metastatic colorectal cancer (mCRC), many patients initially respond, but then show…”
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The TRAR gene classifier to predict response to neoadjuvant therapy in HER2‐positive and ER‐positive breast cancer patients: an explorative analysis from the NeoSphere trial by Triulzi, Tiziana, Bianchini, Giampaolo, Di Cosimo, Serena, Pienkowski, Tadeusz, Im, Young‐Hyuck, Bianchi, Giulia Valeria, Galbardi, Barbara, Dugo, Matteo, De Cecco, Loris, Tseng, Ling‐Ming, Liu, Mei‐Ching, Bermejo, Begoña, Semiglazov, Vladimir, Viale, Giulia, Haba‐Rodriguez, Juan, Oh, Do‐Youn, Poirier, Brigitte, Valagussa, Pinuccia, Gianni, Luca, Tagliabue, Elda

“…As most erb‐b2 receptor tyrosine kinase 2 (HER2)‐positive breast cancer (BC) patients currently receive dual HER2‐targeting added to neoadjuvant chemotherapy,…”
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A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer by Peñarando, Jon, López-Sánchez, Laura M, Mena, Rafael, Guil-Luna, Silvia, Conde, Francisco, Hernández, Vanessa, Toledano, Marta, Gudiño, Victoria, Raponi, Michela, Billard, Caroline, Villar, Carlos, Díaz, César, Gómez-Barbadillo, José, De la Haba-Rodríguez, Juan, Myant, Kevin, Aranda, Enrique, Rodríguez-Ariza, Antonio

“…Nitric oxide (NO) has been highlighted as an important agent in cancer-related events. Although the inducible nitric oxide synthase (iNOS) isoform has received…”
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Altered S-nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab by Cañas, Amanda, López-Sánchez, Laura M., Peñarando, Jon, Valverde, Araceli, Conde, Francisco, Hernández, Vanessa, Fuentes, Elena, López-Pedrera, Chary, de la Haba-Rodríguez, Juan R., Aranda, Enrique, Rodríguez-Ariza, Antonio

“…The monoclonal antibody trastuzumab against HER2/neu, which is overexpressed in 15–20% of breast cancers, has clinical efficacy but many patients do not…”
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A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse by Prat, Aleix, Lluch, Ana, Turnbull, Arran K, Dunbier, Anita K, Calvo, Lourdes, Albanell, Joan, de la Haba-Rodríguez, Juan, Arcusa, Angels, Chacón, José Ignacio, Sánchez-Rovira, Pedro, Plazaola, Arrate, Muñoz, Montserrat, Paré, Laia, Parker, Joel S, Ribelles, Nuria, Jimenez, Begoña, Bin Aiderus, Abdul Aziz, Caballero, Rosalía, Adamo, Barbara, Dowsett, Mitch, Carrasco, Eva, Martín, Miguel, Dixon, J Michael, Perou, Charles M, Alba, Emilio

“…Hormone receptor-positive (HR ) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities…”
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Quality of life with palbociclib plus fulvestrant versus placebo plus fulvestrant in postmenopausal women with endocrine-sensitive hormone receptor-positive and HER2-negative advanced breast cancer: patient-reported outcomes from the FLIPPER trial by Tibau, Ariadna, Martínez, M. Teresa, Ramos, Manuel, De La Cruz-Merino, Luis, Santaballa, Ana, O’Connor, Miriam, Martínez-Jañez, Noelia, Moreno, Fernando, Fernández, Isaura, Virizuela, Juan Antonio, Alarcón, Jesús, de La Haba-Rodríguez, Juan, Sánchez-Rovira, Pedro, Albacar, Cinta Rosa, Bueno Muiño, Coralia, Kelly, Catherine, Casas, Maribel, Bezares, Susana, Rosell, Libertad, Albanell, Joan

“…Background: In the FLIPPER trial, palbociclib/fulvestrant significantly improved progression-free survival (PFS) compared with placebo/fulvestrant in…”
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In-silico drug repurposing study predicts the combination of pirfenidone and melatonin as a promising candidate therapy to reduce SARS-CoV-2 infection progression and respiratory distress caused by cytokine storm by Artigas, Laura, Coma, Mireia, Matos-Filipe, Pedro, Aguirre-Plans, Joaquim, Farrés, Judith, Valls, Raquel, Fernandez-Fuentes, Narcis, de la Haba-Rodriguez, Juan, Olvera, Alex, Barbera, Jose, Morales, Rafael, Oliva, Baldo, Mas, Jose Manuel, Srinivasan, Narayanaswamy

“…From January 2020, COVID-19 is spreading around the world producing serious respiratory symptoms in infected patients that in some cases can be complicated by…”
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Maintenance of S-nitrosothiol homeostasis plays an important role in growth suppression of estrogen receptor-positive breast tumors by Cañas, Amanda, López-Sánchez, Laura M, Valverde-Estepa, Araceli, Hernández, Vanessa, Fuentes, Elena, Muñoz-Castañeda, Juan R, López-Pedrera, Chary, De La Haba-Rodríguez, Juan R, Aranda, Enrique, Rodríguez-Ariza, Antonio

“…Protein denitrosylation by thioredoxin reductase (TrxR) is key for maintaining S-nitrosothiol (SNO) homeostasis, although its role in tumor progression is…”
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Association of Tumor Budding With Immune Evasion Pathways in Primary Colorectal Cancer and Patient-Derived Xenografts by Guil-Luna, Silvia, Mena, Rafael, Navarrete-Sirvent, Carmen, López-Sánchez, Laura María, Khouadri, Karima, Toledano-Fonseca, Marta, Mantrana, Ana, Guler, Ipek, Villar, Carlos, Díaz, Cesar, Medina-Fernández, Francisco Javier, De la Haba-Rodríguez, Juan Rafael, Aranda, Enrique, Rodríguez-Ariza, Antonio

“…Tumor budding has been found to be of prognostic significance for several cancers, including colorectal cancer (CRC). Additionally, the molecular…”
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