Search Results - "De la Flor, Raul"

Multiple Sclerosis: LIFNano-CD4 for Trojan Horse Delivery of the Neuro-Protective Biologic "LIF" Into the Brain: Preclinical Proof of Concept by de la Flor, Raul, Robertson, Janette, Shevchenko, Rostislav V, Alavijeh, Mo, Bickerton, Sean, Fahmy, Tarek, Metcalfe, Su M

“…Multiple sclerosis (MS) is a demyelinating autoimmune disease that attacks the brain, with year-on-year loss of brain volume, starting late teens and becoming…”
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Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR by Fricker, Anne-Cécile, Selina Mok, M.H., de la Flor, Raúl, Shah, Ajit J., Woolley, Marie, Dawson, Lee A., Kew, James N.C.

“…A group II metabotropic glutamate receptor (mGluR) agonist was recently reported to be clinically efficacious against symptoms of schizophrenia [Patil, S.T.,…”
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In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia by Dawson, Lee A, Cato, Katherine J, Scott, Claire, Watson, Jeannette M, Wood, Martyn D, Foxton, Richard, de la Flor, Raúl, Jones, Gareth A, Kew, James Nc, Cluderay, Jane E, Southam, Eric, Murkitt, Graham S, Gartlon, Jane, Pemberton, Darrel J, Jones, Declan Nc, Davies, Ceri H, Hagan, Jim

“…Neurokinin-3 (NK3) receptors are concentrated in forebrain and basal ganglia structures within the mammalian CNS. This distribution, together with the…”
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Augmentation of antipsychotic-induced neurochemical changes by the NK3 receptor antagonist talnetant (SB-223412) by de la Flor, Raúl, Dawson, Lee A

“…Neurokinin-3 (NK(3)) receptor distribution and its modulatory influence on dopaminergic and noradrenergic neurotransmission have lead to the hypothesis that…”
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Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts by Shah, Ajit J., de la Flor, Raúl, Atkins, Alan, Slone-Murphy, Julia, Dawson, Lee A.

“…A liquid chromatography–tandem mass spectrometric method has been developed for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate. The…”
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SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain by Thomas, David R, Soffin, Ellen M, Roberts, Claire, Kew, James N C, de la Flor, Raul M, Dawson, Lee A, Fry, Victoria A, Coggon, Sara A, Faedo, Stefania, Hayes, Philip D, Corbett, David F, Davies, Ceri H, Hagan, Jim J

“…This study utilised the selective 5-ht(5A) receptor antagonist, SB-699551-A…”
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In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by DAWSON, Lee A, LANGMEAD, Christopher J, HILL, Mark D, JONES, Declan N. C, DAVIES, Ceri H, HAGAN, Jim J, SMITH, Paul W, DADA, Adeshola, WATSON, Jeannette M, ZINING WU, DE LA FLOR, Raúl, JONES, Gareth A, CLUDERAY, Jane E, SOUTHAM, Eric, MURKITT, Graham S

“…Clinical evaluation of tachykinin NK(3) receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However, these…”
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Dermal microdialysis: A method to determine drug levels in the skin of patients with Post kala-azar dermal leishmaniasis (PKDL) by Wijnant, Gert-Jan, Moulik, Srija, Chatterjee, Kingshuk, Das, Nilay K, de la Flor, Raúl, Van Bocxlaer, Katrien, Croft, Simon L, Chatterjee, Mitali

“…Post-kala-azar-dermal leishmaniasis (PKDL) is an infectious skin disease that occurs as sequela of visceral leishmaniasis (VL) and causes cutaneous lesions on…”
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Pharmacokinetics and Pharmacodynamics of the Nitroimidazole DNDI-0690 in Mouse Models of Cutaneous Leishmaniasis by Wijnant, Gert-Jan, Croft, Simon L, de la Flor, Raul, Alavijeh, Mo, Yardley, Vanessa, Braillard, Stéphanie, Mowbray, Charles, Van Bocxlaer, Katrien

“…The nitroimidazole DNDI-0690 is a clinical drug candidate for visceral leishmaniasis (VL) that also shows potent and activity against cutaneous leishmaniasis…”
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In vitro and in vivo comparison of two non-peptide tachykinin NK sub(3) receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by Dawson, Lee A, Langmead, Christopher J, Dada, Adeshola, Watson, Jeannette M, Wu, Zining, De la Flor, Raul, Jones, Gareth A, Cluderay, Jane E, Southam, Eric, Murkitt, Graham S, Hill, Mark D, Jones, Declan NC, Davies, Ceri H, Hagan, Jim J, Smith, Paul W

“…Clinical evaluation of tachykinin NK sub(3) receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However,…”
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SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N- [(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl] propanamide dihydrochloride), a novel 5-ht sub(5A) receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht sub(5A) receptor in guinea pig brain by Thomas, David R, Soffin, Ellen M, Roberts, Claire, Kew, James NC, De la Flor, Raul M, Dawson, Lee A, Fry, Victoria A, Coggon, Sara A, Faedo, Stefania, Hayes, Philip D, Corbett, David F, Davies, Ceri H, Hagan, Jim J

“…This study utilised the selective 5-ht sub(5A) receptor antagonist, SB-699551- A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-…”
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SB-699551-A (3-cyclopentyl- N-[2-(dimethylamino)ethyl]- N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride), a novel 5-ht 5A receptor-selective antagonist, enhances 5-HT neuronal function: Evidence for an autoreceptor role for the 5-ht 5A receptor in guinea pig brain by Thomas, David R., Soffin, Ellen M., Roberts, Claire, Kew, James N.C., de la Flor, Raul M., Dawson, Lee A., Fry, Victoria A., Coggon, Sara A., Faedo, Stefania, Hayes, Philip D., Corbett, David F., Davies, Ceri H., Hagan, Jim J.

“…This study utilised the selective 5-ht 5A receptor antagonist, SB-699551-A (3-cyclopentyl- N-[2-(dimethylamino)ethyl]-…”
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Augmentation of antipsychotic-induced neurochemical changes by the NK 3 receptor antagonist talnetant (SB-223412) by de la Flor, Raúl, Dawson, Lee A.

“…Neurokinin-3 (NK 3) receptor distribution and its modulatory influence on dopaminergic and noradrenergic neurotransmission have lead to the hypothesis that NK…”
Get full text

In vitro and in vivo comparison of two non-peptide tachykinin NK 3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by Dawson, Lee A., Langmead, Christopher J., Dada, Adeshola, Watson, Jeannette M., Wu, Zining, de la Flor, Raúl, Jones, Gareth A., Cluderay, Jane E., Southam, Eric, Murkitt, Graham S., Hill, Mark D., Jones, Declan N.C., Davies, Ceri H., Hagan, Jim J., Smith, Paul W.

“…Clinical evaluation of tachykinin NK 3 receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However, these…”
Get full text