Search Results - "De Wit, Tobias F.Rinke"
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Primary resistance to integrase strand transfer inhibitors in patients infected with diverse HIV-1 subtypes in sub-Saharan Africa
Published in Journal of antimicrobial chemotherapy (01-05-2018)“…To investigate the prevalence and patterns of major and accessory resistance mutations associated with integrase strand transfer inhibitors (INSTIs), across…”
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Long-term HIV treatment outcomes and associated factors in sub-Saharan Africa: multicountry longitudinal cohort analysis
Published in AIDS (London) (01-08-2022)“…OBJECTIVEIn a multicountry prospective cohort of persons with HIV from six countries between 2007 and 2015, we evaluated long-term outcomes of first-line…”
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Affordable HIV drug-resistance testing for monitoring of antiretroviral therapy in sub-Saharan Africa
Published in The Lancet infectious diseases (01-11-2016)“…Summary Increased provision of antiretroviral therapy in sub-Saharan Africa has led to a growing number of patients with therapy failure and acquired…”
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Response to Abdelrahman M et al commentary on “Parasites Protect from Severe COVID-19. Myth or Reality?”
Published in International journal of infectious diseases (01-07-2022)Get full text
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Community- and facility-based HIV testing interventions in northern Tanzania: Midterm results of Test & Treat Project
Published in PloS one (12-04-2022)“…Test & Treat Project offers universal HIV testing and access to antiretroviral treatment in Northern Tanzania. The current cross-sectional study provides…”
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Performance of a rapid antigen test for SARS-CoV-2 in Kenya
Published in Diagnostic microbiology and infectious disease (01-02-2022)“…Testing for SARS-CoV-2 in resource-poor settings remains a considerable challenge. Gold standard nucleic acid tests are expensive and depend on availability of…”
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HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study
Published in The Lancet infectious diseases (01-10-2011)“…Summary Background There are few data on the epidemiology of primary HIV-1 drug resistance after the roll-out of antiretroviral treatment (ART) in sub-Saharan…”
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HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing
Published in PloS one (30-12-2015)“…The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and…”
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Association between health worker motivation and healthcare quality efforts in Ghana
Published in Human resources for health (14-08-2013)“…Ghana is one of the sub-Saharan African countries making significant progress towards universal access to quality healthcare. However, it remains a challenge…”
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Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
Published in PLoS pathogens (01-12-2019)“…Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world…”
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Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort study
Published in EClinicalMedicine (01-09-2021)“…Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a spectrum of clinical presentations. Evidence from Africa…”
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Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a multicentre cohort study
Published in The Lancet infectious diseases (01-04-2012)“…Summary Background The effect of pretreatment HIV-1 drug resistance on the response to first-line combination antiretroviral therapy (ART) in sub-Saharan…”
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Adherence to antiretroviral therapy for HIV in sub‐Saharan Africa and Asia: a comparative analysis of two regional cohorts
Published in Journal of the International AIDS Society (03-03-2017)“…Introduction: Our understanding of how to achieve optimal long‐term adherence to antiretroviral therapy (ART) in settings where the burden of HIV disease is…”
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Predictors of testing history and new HIV diagnosis among adult outpatients seeking care for symptoms of acute HIV infection in coastal Kenya: a cross-sectional analysis of intervention participants in a stepped-wedge HIV testing trial
Published in BMC public health (11-02-2022)“…HIV testing is the first step to stop transmission. We aimed to evaluate HIV testing history and new diagnoses among adult outpatients in Kenya aged…”
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Evaluation of the Eiken latex agglutination test for anti- Toxoplasma antibodies and seroprevalence of Toxoplasma infection among factory workers in Addis Ababa, Ethiopia
Published in Transactions of the Royal Society of Tropical Medicine and Hygiene (01-07-1998)“…Sera from 170 factory workers aged 18–45 years enrolled in a pilot study of human immunodeficiency virus 1 (HIV-1) infection in Addis Ababa, Ethiopia, were…”
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Chronic Immune Activation and CD4 + T Cell Lymphopenia in Healthy African Individuals: Perspectives for SARS-CoV-2 Vaccine Efficacy
Published in Frontiers in immunology (17-06-2021)“…Chronic immune activation has been considered as the driving force for CD4 T cell depletion in people infected with HIV-1. Interestingly, the normal immune…”
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Effectiveness of provider-initiated versus client-initiated HIV testing by different health facility departments in Northern Tanzania
Published in AIDS research and therapy (07-07-2023)“…HIV prevalence in Tanzania is still high at 4.7% among adults. Regular HIV testing is consistently advocated in the country to increase the level of awareness…”
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Evaluating the sustainability of differentiated service delivery interventions for stable ART clients in sub-Saharan Africa: a systematic review protocol
Published in BMJ open (02-02-2020)“…IntroductionIn 2015, WHO recommended immediate treatment for people living with HIV (PLHIV). As a result, the number of PLHIV needing antiretroviral therapy…”
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Effect of a customized digital adherence tool on retention in care and adherence to antiretroviral treatment in breastfeeding women, children and adolescents living with HIV in Tanzania: a mixed-methods study followed by clinical trials
Published in Current controlled trials in cardiovascular medicine (21-04-2023)“…Adherence to antiretroviral (ARV) treatment for HIV infection is challenging because of many factors. The World Health Organization (WHO) has recommended using…”
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HIV-1-resistance-associated mutations after failure of first-line antiretroviral treatment among children in resource-poor regions: a systematic review
Published in The Lancet infectious diseases (01-10-2011)“…Summary HIV-positive children are at high risk of drug resistance, which is of particular concern in settings where antiretroviral options are limited. In this…”
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