Search Results - "De Weger, Roel A"

Distinct fibrosis pattern in desmosomal and phospholamban mutation carriers in hereditary cardiomyopathies by Sepehrkhouy, Shahrzad, MD, Gho, Johannes M.I.H., MD, van Es, René, MSc, Harakalova, Magdalena, MD, PhD, de Jonge, Nicolaas, MD, PhD, Dooijes, Dennis, PhD, van der Smagt, Jasper J., MD, PhD, Buijsrogge, Marc P., MD, PhD, Hauer, Richard N.W., MD, PhD, Goldschmeding, Roel, MD, PhD, de Weger, Roel A., PhD, Asselbergs, Folkert W., MD, PhD, Vink, Aryan, MD, PhD

“…Abstract Background Desmosomal and phospholamban (PLN) mutations are associated with arrhythmogenic cardiomyopathy. Ultimately, most cardiomyopathy hearts…”
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The composition of ectopic lymphoid structures suggests involvement of a local immune response in cardiac allograft vasculopathy by Huibers, Manon M.H., MSc, Gareau, Alison J., PhD, Vink, Aryan, MD, PhD, Kruit, Rianne, MSc, Feringa, Hannah, BSc, Beerthuijzen, Johanna M.T., BSc, Siera-de Koning, Erica, BSc, Peeters, Ton, BSc, Jonge, Nicolaas de, MD, PhD, de Weger, Roel A., PhD, Lee, Timothy D.G., PhD

“…Background Cardiac allograft vasculopathy (CAV) is a multifactorial pathology limiting the survival of cardiac transplants. The etiology of CAV is unclear, but…”
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The use of droplet digital PCR in liquid biopsies: A highly sensitive technique for MYD88 p.(L265P) detection in cerebrospinal fluid by Hiemcke‐Jiwa, Laura S., Minnema, Monique C., Radersma‐van Loon, Joyce H., Jiwa, N. Mehdi, Boer, Mirthe, Leguit, Roos J., Weger, Roel A., Huibers, Manon M.H.

“…The gold standard for diagnosis of central nervous system lymphomas still regards a stereotactic brain biopsy, with the risk of major complications for the…”
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Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure by Raso, Andrea, Dirkx, Ellen, Philippen, Leonne E., Fernandez-Celis, Amaya, De Majo, Federica, Sampaio-Pinto, Vasco, Sansonetti, Marida, Juni, Rio, el Azzouzi, Hamid, Calore, Martina, Bitsch, Nicole, Olieslagers, Servé, Oerlemans, Martinus I.F.J., Huibers, Manon M., de Weger, Roel A., Reckman, Yolan J., Pinto, Yigal M., Zentilin, Lorena, Zacchigna, Serena, Giacca, Mauro, da Costa Martins, Paula A., López-Andrés, Natalia, De Windt, Leon J.

“…Heart failure is preceded by ventricular remodeling, changes in left ventricular mass, and myocardial volume after alterations in loading conditions…”
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Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material by de Leng, Wendy W J, Gadellaa-van Hooijdonk, Christa G, Barendregt-Smouter, Françoise A S, Koudijs, Marco J, Nijman, Ies, Hinrichs, John W J, Cuppen, Edwin, van Lieshout, Stef, Loberg, Robert D, de Jonge, Maja, Voest, Emile E, de Weger, Roel A, Steeghs, Neeltje, Langenberg, Marlies H G, Sleijfer, Stefan, Willems, Stefan M, Lolkema, Martijn P

“…Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is…”
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Molecular analysis in liquid biopsies for diagnostics of primary central nervous system lymphoma: Review of literature and future opportunities by Hiemcke-Jiwa, Laura S., Leguit, Roos J., Snijders, Tom J., Jiwa, N. Mehdi, Kuiper, Jonas. J.W., de Weger, Roel A., Minnema, Monique C., Huibers, Manon M.H.

“…•Many genetic aberrations reported in PCNSL are implicated in the NFkB pathway.•Only few targets for liquid biopsy analysis in PCNSL are currently…”
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Absence of chromosome 17 polysomy in breast cancer: analysis by CEP17 chromogenic in situ hybridization and multiplex ligation-dependent probe amplification by Moelans, Cathy B, de Weger, Roel A, van Diest, Paul J

“…Amplification of the HER2 gene, present in 15-30% of breast carcinomas, correlates with poor outcome and is an indication for treatment with trastuzumab…”
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Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy by Noorman, Maartje, PhD, Hakim, Sara, MD, Kessler, Elise, BSc, Groeneweg, Judith A, MD, Cox, Moniek G.P.J., MD, PhD, Asimaki, Angeliki, PhD, van Rijen, Harold V.M., PhD, van Stuijvenberg, Leonie, BSc, Chkourko, Halina, MSc, van der Heyden, Marcel A.G., PhD, Vos, Marc A., PhD, de Jonge, Nicolaas, MD, van der Smagt, Jasper J., PhD, Dooijes, Dennis, PhD, Vink, Aryan, MD, PhD, de Weger, Roel A., PhD, Varro, Andras, PhD, de Bakker, Jacques M.T., PhD, Saffitz, Jeffrey E., MD, PhD, Hund, Thomas J., PhD, Mohler, Peter J., PhD, Delmar, Mario, MD, PhD, FHRS, Hauer, Richard N.W., MD, PhD, van Veen, Toon A.B., PhD

“…Background Arrhythmogenic cardiomyopathy (AC) is closely associated with desmosomal mutations in a majority of patients. Arrhythmogenesis in patients with AC…”
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Immune Regulators Regulated to Prevent Transplant Reactions by de Weger, Roel A., PhD

“…[...]it should be noted that HTx patients who develop CAV are undergoing constant immunosuppressive therapy and that analysis of the cytokines produced…”
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Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes by Moelans, Cathy B, de Weger, Roel A, Monsuur, Hanneke N, Vijzelaar, Raymon, van Diest, Paul J

“…Several oncogenes and tumor-suppressor genes have been shown to be implicated in the development, progression and response to therapy of invasive breast…”
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Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood by Vercoulen, Yvonne, Bellutti Enders, Felicitas, Meerding, Jenny, Plantinga, Maud, Elst, Elisabeth F, Varsani, Hemlata, van Schieveen, Christa, Bakker, Mette H, Klein, Mark, Scholman, Rianne C, Spliet, Wim, Ricotti, Valeria, Koenen, Hans J P M, de Weger, Roel A, Wedderburn, Lucy R, van Royen-Kerkhof, Annet, Prakken, Berent J

“…Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T…”
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High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy by Gho, Johannes M I H, van Es, René, Stathonikos, Nikolas, Harakalova, Magdalena, te Rijdt, Wouter P, Suurmeijer, Albert J H, van der Heijden, Jeroen F, de Jonge, Nicolaas, Chamuleau, Steven A J, de Weger, Roel A, Asselbergs, Folkert W, Vink, Aryan

“…Myocardial fibrosis can lead to heart failure and act as a substrate for cardiac arrhythmias. In dilated cardiomyopathy diffuse interstitial reactive fibrosis…”
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MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices by Lok, Sjoukje I, de Jonge, Nicolaas, van Kuik, Joyce, van Geffen, Ankie J P, Huibers, Manon M H, van der Weide, Petra, Siera, Erica, Winkens, Bjorn, Doevendans, Pieter A, de Weger, Roel A, da Costa Martins, Paula A

“…Pulsatile flow left ventricular assist devices (pf-LVADs) are being replaced by continuous flow LVADs (cf-LVADs) in patients with end-stage heart failure (HF)…”
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Cardiomyocyte Specific Deletion of ADAR1 Causes Severe Cardiac Dysfunction and Increased Lethality by El Azzouzi, Hamid, Vilaça, Andreia P, Feyen, Dries A M, Gommans, Willemijn M, de Weger, Roel A, Doevendans, Pieter A F, Sluijter, Joost P G

“…Adenosine deaminase acting on RNA 1 (ADAR1) is a double-stranded RNA-editing enzyme that is involved in several functions including the deamination of…”
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Distinct phenotypes of cardiac allograft vasculopathy after heart transplantation: A histopathological study by Huibers, Manon M.H, Vink, Aryan, Kaldeway, Johannes, Huisman, André, Timmermans, Kim, Leenders, Max, Schipper, Marguèrite E.I, Lahpor, Jaap R, Kirkels, Hans J.H, Klöpping, Corinne, de Jonge, Nicolaas, de Weger, Roel A

“…Abstract Introduction Long-term survival after heart transplantation (HTx) is hampered by cardiac allograft vasculopathy (CAV). Better understanding of the…”
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Simultaneous Detection of Clinically Relevant Mutations and Amplifications for Routine Cancer Pathology by Hoogstraat, Marlous, Hinrichs, John W.J, Besselink, Nicolle J.M, Radersma-van Loon, Joyce H, de Voijs, Carmen M.A, Peeters, Ton, Nijman, Isaac J, de Weger, Roel A, Voest, Emile E, Willems, Stefan M, Cuppen, Edwin, Koudijs, Marco J

“…In routine cancer molecular pathology, various independent experiments are required to determine mutation and amplification status of clinically relevant…”
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Modifying Graft-versus-Host Disease in a Humanized Mouse Model by Targeting Macrophages or B-Cells by de Weger, Roel A., Martens, Anton C., Guedes, Liane, ter Hoeve, Natalie, Monteiro, Filipa R. P., van Kuik, Joyce, van Dorp, Suzanne, Hogenes, Marieke C. H., van Dijk, Marijke R.

“…Humanized mouse models can well be modified to study specific aspects of Graft-versus-Host Disease (GvHD). This paper shows the results of both macrophage…”
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EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung adenocarcinoma by Smits, Alexander J. J., Kummer, J. Alain, Hinrichs, John W. J., Herder, Gerarda J. M., Scheidel-Jacobse, Karen C., Jiwa, N. Mehdi, Ruijter, T. Emiel G., Nooijen, Peet T. G. A., Looijen-Salamon, Monica G., Ligtenberg, Marjolijn J. L., Thunnissen, Frederik B., Heideman, Daniëlle A. M., de Weger, Roel A., Vink, Aryan

“…Background Frequencies of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) have predominantly been determined in East Asian and North American…”
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One-fits-all pretreatment protocol facilitating Fluorescence In Situ Hybridization on formalin-fixed paraffin-embedded, fresh frozen and cytological slides by Richardson, Shivanand O, Huibers, Manon M H, de Weger, Roel A, de Leng, Wendy W J, Hinrichs, John W J, Meijers, Ruud W J, Willems, Stefan M, Peeters, Ton L M G

“…The Fluorescence In Situ Hybridization (FISH) technique is a very useful tool for diagnostic and prognostic purposes in molecular pathology. However, clinical…”
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Lymphoblastic lymphoma with a triple hit profile: a rare but distinct and relevant entity by Hiemcke-Jiwa, Laura S., MD, Leguit, Roos J., MD, van der Veken, Lars T., PhD, Buijs, Arjan, PhD, Leeuwis, Jan Willem, MD, PhD, de Boer, Mirthe, MD, Jiwa, N. Mehdi, MD, PhD, Bloem, Andries C., PhD, Petersen, Eefke J., MD, PhD, de Weger, Roel A., PhD, Huibers, Manon M.H., PhD

“…Summary Follicular lymphoma with progression to a high grade lymphoma bears a poor prognosis. We describe a case of a 60-year old man who presented in 2012…”
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