Search Results - "De Weger, RA"

Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation : impact of infused and residual donor T cells by VERDONCK, L. F, PETERSEN, E. J, LOKHORST, H. M, NIEUWENHUIS, H. K, DEKKER, A. W, TILANUS, M. G. J, DE WEGER, R. A

“…We evaluated the efficacy and toxicity of different doses of donor T cells given with donor leukocyte infusions (DLI) as treatment for relapse of various…”
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A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- γc-/- double-mutant mice by van Rijn, Rozemarijn S., Simonetti, Elles R., Hagenbeek, Anton, Hogenes, MariekeC.H., de Weger, Roel A., Canninga-van Dijk, Marijke R., Weijer, Kees, Spits, Hergen, Storm, Gert, van Bloois, Louis, Rijkers, Ger, Martens, AntonC.M., Ebeling, Saskia B.

“…The safe application of new strategies for the treatment of graft-versus-host disease (GVHD) is hampered by the lack of a clinically relevant model for…”
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Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia by HUISMAN, C, DE WEGER, R. A, DE VRIES, L, TILANUS, M. G. J, VERDONCK, L. F

“…The role of chimerism analysis as a prognostic indicator of relapse after hematopoietic stem cell transplantation (SCT) is controversial. We monitored…”
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NFκB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts by Vos, Ingrid H. C., Govers, Roland, Gröne, Hermann‐Josef, Kleij, Livio, Schurink, Merel, De Weger, Roel A., Goldschmeding, Roel, Rabelink, Ton J.

“…Monocyte influx secondary to ischemia‐reperfusion conditions the renal allograft to rejection by presentation of antigens and production of cytokines. Monocyte…”
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T cells in Cardiac Allograft Vasculopathy Are Skewed to Memory Th‐1 Cells in the Presence of a Distinct Th‐2 Population by Hagemeijer, M. C., Van Oosterhout, M. F. M., Van Wichen, D. F., Van Kuik, J., Siera‐de Koning, E., Gmelig Meyling, F. H. J., Schipper, M. E. I., De Jonge, N., De Weger, R. A.

“…Cardiac allograft vasculopathy (CAV) in heart transplantation (HTx) patients remains the major complication for long‐term survival, due to concentric neointima…”
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Left ventricular assist device in end-stage heart failure: Persistence of structural myocyte damage after unloading: An immunohistochemical analysis of the contractile myofilaments by DE JONGE, Nicolaas, VAN WICHEN, Dick F, SCHIPPER, Marguerite E. I, LAHPOR, Jaap R, GMELIG-MEYLING, Frits H. J, ROBLES DE MEDINA, Etienne O, DE WEGER, Roel A

“…We sought to evaluate the contractile proteins in cardiomyocytes of patients with end-stage heart failure (HF) before and after mechanical support with a left…”
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TNFα in patients with end-stage heart failure on medical therapy or supported by a left ventricular assist device by Bruggink, A.H, van Oosterhout, M.F.M, De Jonge, N, Gmelig-Meyling, F.H.J, De Weger, R.A

“…Abstract Background In the heart elevated levels of TNFα can cause lethal heart failure, like Dilated Cardiomyopathy (DCM). The level of TNFα production is in…”
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Suppression of physiological cardiomyocyte proliferation in the rat pup after neonatal glucocorticosteroid treatment by de Vries, Willem B, Bal, Miriam P, Homoet-van der Kraak, Petra, Kamphuis, Patrick J G H, van der Leij, Feike R, Baan, Jan, Steendijk, Paul, de Weger, Roel A, van Bel, Frank, van Oosterhout, Matthijs F M

“…Glucocorticosteroids (mostly dexamethasone) are widely used to prevent chronic lung disease in premature infants. Neonatal rats treated with dexamethasone have…”
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Primary Tumor Cells of Myeloma Patients Induce Interleukin-6 Secretion in Long-Term Bone Marrow Cultures by Lokhorst, Henk M., Lamme, Tanja, Smet, Martin de, Klein, Siegrid, Weger, Roel A. de, Oers, Rien van, Bloem, Andries C.

“…Long-term bone marrow cultures (LTBMC) from patients with multiple myeloma (MM) and normal donors were analyzed for immunophenotype and cytokine production…”
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Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers by Kropveld, A, Rozemuller, E H, Leppers, F G, Scheidel, K C, de Weger, R A, Koole, R, Hordijk, G J, Slootweg, P J, Tilanus, M G

“…Data on p53 alterations in human cancers are mainly based on studies restricted to the core domain (exons 5-9), because mutations outside this region are…”
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Cardiomyocyte death in patients with end-stage heart failure before and after support with a left ventricular assist device: low incidence of apoptosis despite ubiquitous mediators by de Jonge, Nicolaas, van Wichen, Dick F, van Kuik, Joyce, Kirkels, Hans, Lahpor, Jaap R, Gmelig-Meyling, Frits H J, van den Tweel, Jan G, de Weger, Roel A

“…Left ventricular assist device (LVAD) implantation in patients with end-stage heart failure results in impressive hemodynamic improvement. The effects on…”
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Adhesion molecule expression on skin endothelia in atopic dermatitis: Effects of TNF-α and IL-4 by de Vries, I.Jolanda M., Langeveld-Wildschut, Elisabeth G., van Reijsen, Frank C., Dubois, Gerald R., van den Hoek, J.Annet, Bihari, Ilse C., van Wichen, Dick, de Weger, Roel A., Knol, Edward F., Thepen, Theo, Bruijnzeel-Koomen, Carla A.F.M.

“…Background: Atopic dermatitis (AD) is characterized by skin infiltrates of leukocytes, such as lymphocytes and eosinophils. Objective: To describe the…”
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Deletion of chromosomal region 6q14‐16 in prostate cancer by Verhagen, Paul C.M.S., Hermans, Karin G.L., Brok, Mariel O., van Weerden, Wytzke M., Tilanus, Marcel G.J., de Weger, Roel A., Boon, Tom A., Trapman, Jan

“…A detailed analysis of chromosome 6 in DNAs from prostate cancers was performed, to define a region for subsequent search for cancer genes. DNA from 4 prostate…”
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Complete remission of a radiochemotherapy-resistant cutaneous T-cell lymphoma with allogeneic non-myeloablative stem cell transplantation by Fijnheer, R, Sanders, C J G, Canninga, M R, de Weger, R A, Verdonck, L F

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Sentinel node biopsies in melanoma patients: a protocol for accurate, efficient, and cost-effective analysis by preselection for immunohistochemistry on the basis of Tyr-PCR by van der Velde-Zimmermann, D, Schipper, M E, de Weger, R A, Hennipman, A, Borel Rinkes, I H

“…Immunohistochemistry (IHC) of serial sectioning is considered the gold standard for detection of melanoma activity in sentinel node (SN) biopsies. However,…”
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Monitoring of residual disease and guided donor leucocyte infusion after allogeneic bone marrow transplantation by chimaerism analysis with short tandem repeats by De Weger, Roel A., Tilanus, Marcel G. J., Scheidel, Karen C., Van Den Tweel, Jan G., Verdonck, Leo F.

“…In this study, we analysed the chimaeric status of peripheral blood leucocytes (PBLs) in recipients of allogeneic bone marrow transplantation (BMT) with the…”
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Localization in situ of costimulatory molecules and cytokines in B‐cell non‐Hodgkin’s lymphoma by Vyth-Dreese, F A, Boot, H, Dellemijn, T A, Majoor, D M, Oomen, L C, Laman, J D, Van Meurs, M, De Weger, R A, De Jong, D

“…Costimulatory molecules are essential in cognate interactions between T and B lymphocytes. To study the prerequisites of functional interactions between…”
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Molecular test for the detection of tumor cells in blood and sentinel nodes of melanoma patients by Van der Velde-Zimmermann, D, Roijers, JF, Bouwens-Rombouts, A, De Weger, RA, De Graaf, PW, Tilanus, MG, Van den Tweel, JG

“…Lymph node metastasis dramatically decreases the 5-year survival of melanoma patients. The so-called sentinel node surgery offers a therapeutic approach to…”
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Prognostic Factors in Localised Prostate Cancer with Emphasis on the Application of Molecular Techniques by Verhagen, P.C.M.S, Tilanus, M.G.J, de Weger, R.A, van Moorselaar, R.J.A, van den Tweel, J.G, Boon, T.A

“…Prostate cancer is the most prevalent malignancy in males in the Western world and the second leading cause of male cancer death. Prostate specific antigen…”
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Similar left and right ventricular sarcomere structure after support with a left ventricular assist device suggests the utility of right ventricular biopsies to monitor left ventricular reverse remodeling by de Jonge, Nicolaas, Lahpor, Jaap R., van Wichen, Dick F., Kirkels, Hans, Gmelig-Meyling, Frits H.J., van den Tweel, Jan G., Doevendans, Pieter A., de Weger, Roel A.

“…Background: To evaluate whether the morphology of the contractile filaments in cardiomyocytes of patients with end-stage heart failure, treated with a left…”
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