Search Results - "De Waart, D. Rudi"

Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport by Paulusma, Coen C., Groen, Annemiek, Kunne, Cindy, Ho‐Mok, Kam S., Spijkerboer, Astrid L., Rudi de Waart, D., Hoek, Frans J., Vreeling, Heleen, Hoeben, Kees A., van Marle, Jan, Pawlikowska, Ludmila, Bull, Laura N., Hofmann, Alan F., Knisely, A. S., Oude Elferink, Ronald P. J.

“…Progressive familial intrahepatic cholestasis type 1 (PFIC1, Byler disease, OMIM 211600) is a severe inherited liver disease caused by mutations in ATP8B1…”
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ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity by Paulusma, Coen C., Folmer, Dineke E., Ho‐Mok, Kam S., de Waart, D. Rudi, Hilarius, Petra M., Verhoeven, Arthur J., Oude Elferink, Ronald P. J.

“…Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1. Previously, we have shown…”
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Stable Overexpression of the Constitutive Androstane Receptor Reduces the Requirement for Culture with Dimethyl Sulfoxide for High Drug Metabolism in HepaRG Cells by van der Mark, Vincent A, Rudi de Waart, D, Shevchenko, Valery, Elferink, Ronald P J Oude, Chamuleau, Robert A F M, Hoekstra, Ruurdtje

“…Dimethylsulfoxide (DMSO) induces cellular differentiation and expression of drug metabolic enzymes in the human liver cell line HepaRG; however, DMSO also…”
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Activity of the Bile Salt Export Pump (ABCB11) Is Critically Dependent on Canalicular Membrane Cholesterol Content by Paulusma, Coen C., de Waart, D.Rudi, Kunne, Cindy, Mok, Kam S., Elferink, Ronald P.J.Oude

“…Mutations in ATP8B1 cause severe inherited liver disease. The disease is characterized by impaired biliary bile salt excretion (cholestasis), but the mechanism…”
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The lipid flippase heterodimer ATP8B1–CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells by van der Mark, Vincent A., de Waart, D. Rudi, Ho-Mok, Kam S., Tabbers, Merit M., Voogt, Heleen W., Oude Elferink, Ronald P.J., Knisely, A.S., Paulusma, Coen C.

“…Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic…”
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Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis by van de Wiel, Sandra M.W., Porteiro, Begoña, Belt, Saskia C., Vogels, Esther W.M., Bolt, Isabelle, Vermeulen, Jacqueline L.M., de Waart, D. Rudi, Verheij, Joanne, Muncan, Vanesa, Oude Elferink, Ronald P.J., van de Graaf, Stan F.J.

“…Organic solute transporter (OST) subunits OSTα and OSTβ facilitate bile acid efflux from the enterocyte into the portal circulation. Patients with deficiency…”
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Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and Extrahepatic Ammonia Detoxification by He, Youji, Hakvoort, Theodorus B.M., Köhler, S. Eleonore, Vermeulen, Jacqueline L.M., de Waart, D. Rudi, de Theije, Chiel, ten Have, Gabrie A.M., van Eijk, Hans M.H., Kunne, Cindy, Labruyere, Wilhelmina T., Houten, Sander M., Sokolovic, Milka, Ruijter, Jan M., Deutz, Nicolaas E.P., Lamers, Wouter H.

“…The main endogenous source of glutamine is de novo synthesis in striated muscle via the enzyme glutamine synthetase (GS). The mice in which GS is selectively…”
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Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β by van de Wiel, Sandra M.W, de Waart, D. Rudi, Oude Elferink, Ronald P.J, van de Graaf, Stan F.J

“…Background & Aims The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal…”
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Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis by Zweers, Serge J., Shiryaev, Alexey, Komuta, Mina, Vesterhus, Mette, Hov, Johannes R., Perugorria, María J., de Waart, D. Rudi, Chang, Jung-Chin, Tol, Shanna, te Velde, Anje A., de Jonge, Wouter J., Banales, Jesus M., Roskams, Tania, Beuers, Ulrich, Karlsen, Tom H., Jansen, Peter L., Schaap, Frank G.

“…Background & Aims To better understand the pathogenesis of primary sclerosing cholangitis, anti‐ and pro‐inflammatory factors were studied in bile. Methods…”
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Glutamine synthetase deficiency in murine astrocytes results in neonatal death by He, Youji, Hakvoort, Theodorus B. M., Vermeulen, Jacqueline L. M., Labruyère, Wilhelmina T., De Waart, D. Rudi, Van Der Hel, W. Saskia, Ruijter, Jan M., Uylings, Harry B. M., Lamers, Wouter H.

“…Glutamine synthetase (GS) is a key enzyme in the “glutamine‐glutamate cycle” between astrocytes and neurons, but its function in vivo was thus far tested only…”
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Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge by Zweers, Serge J., de Vries, Elisabeth M., Lenicek, Martin, Tolenaars, Dagmar, de Waart, D. Rudi, Koelfat, Kiran V. K., Groen, Albert K., Olde Damink, Steven W. M., Beuers, Ulrich, Ponsioen, Cyriel, Jansen, Peter L. M., Schaap, Frank G.

“…Background Bile salts likely contribute to liver injury in patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC). Fibroblast…”
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Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia by Montenegro-Miranda, Paula S., Sneitz, Nina, de Waart, D. Rudi, ten Bloemendaal, Lysbeth, Duijst, Suzanne, de Knegt, Robert J., Beuers, Ulrich, Finel, Moshe, Bosma, Piter J.

“…As recently demonstrated in patients with factor IX deficiency, adeno‐associated virus (AAV)-mediated liver-directed therapy is a viable option for inherited…”
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Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats by Dietrich, C G, de Waart, D R, Ottenhoff, R, Schoots, I G, Elferink, R P

“…MRP2 is an apical transporter expressed in hepatocytes and the epithelial cells of the small intestine and kidney proximal tubule. It extrudes organic anions,…”
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FXR agonism protects against liver injury in a rat model of intestinal failure-associated liver disease by Olde Damink, Steven

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Lack of UGT1 Isoforms in Gunn Rats Changes Metabolic Ratio and Facilitates Excretion of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by Dietrich, Christoph G., Ottenhoff, Roelof, Rudi de Waart, D., Oude Elferink, Ronald P.J.

“…UDP-glucuronosyltransferases (UGTs) play an important role in detoxification of endo- and xenobiotics. Deficiencies of these enzymes can have serious…”
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FXR agonism protects against liver injury in a rat model of intestinal failure-associated liver disease by Koelfat, Kiran V K, Visschers, Ruben G J, Hodin, Caroline M J M, de Waart, D Rudi, van Gemert, Wim G, Cleutjens, Jack P M, Gijbels, Marion J, Shiri-Sverdlov, Ronit, Mookerjee, Rajeshwar P, Lenaerts, Kaatje, Schaap, Frank G, Steven W M, Olde Damink

“…Intestinal failure-associated liver disease (IFALD) is a clinical challenge. The pathophysiol-ogy is multifactorial and remains poorly understood. Disturbed…”
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Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides by Zelcer, Noam, Wetering, Koen van de, Waart, Rudi de, Scheffer, George L., Marschall, Hanns-Ulrich, Wielinga, Peter R., Kuil, Annemieke, Kunne, Cindy, Smith, Alexander, Valk, Martin van der, Wijnholds, Jan, Elferink, Ronald Oude, Borst, Piet

“…Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether…”
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Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by Dietrich, Christoph G., de Waart, D.Rudi, Ottenhoff, Roel, Bootsma, Albert H., van Gennip, Albert H., Elferink, Ronald P.J.Oude

“…While metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant food-derived heterocyclic amine and carcinogen, has been studied…”
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