Search Results - "De Vos, Abraham M"

The Crystal Structure of Placental Growth Factor in Complex with Domain 2 of Vascular Endothelial Growth Factor Receptor-1 by Christinger, Hans W., Fuh, Germaine, de Vos, Abraham M., Wiesmann, Christian

“…Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and plays an important role in pathological angiogenic…”
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Suppressor of Fused Regulates Gli Activity through a Dual Binding Mechanism by Merchant, Mark, Vajdos, Felix F., Ultsch, Mark, Maun, Henry R., Wendt, Ulrich, Cannon, Jennifer, Desmarais, William, Lazarus, Robert A., de Vos, Abraham M., de Sauvage, Frederic J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Two-Amino Acid Molecular Switch in an Epithelial Morphogen That Regulates Binding to Two Distinct Receptors by Yan, Minhong, Wang, Li-Chong, Hymowitz, Sarah G., Schilbach, Sarah, Lee, James, Goddard, Audrey, de Vos, Abraham M., Gao, Wei-Qiang, Dixit, Vishva M.

“…Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a…”
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VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 å resolution and mutational analysis of the interface by Muller, Yves A, Chen, Yvonne, Christinger, Hans W, Li, Bing, Cunningham, Brian C, Lowman, Henry B, de Vos, Abraham M

“…Background: Vascular endothelial growth factor (VEGF) is a highly specific angiogenic growth factor; anti-angiogenic treatment through inhibition of receptor…”
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Human Growth Hormone and Extracellular Domain of its Receptor: Crystal Structure of the Complex by de Vos, Abraham M., Ultsch, Mark, Kossiakoff, Anthony A.

“…Binding of human growth hormone (hGH) to its receptor is required for regulation of normal human growth and development. Examination of the 2.8 angstrom…”
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Hematopoietic Receptor Complexes by Wells, James A, de Vos, Abraham M

“…Hematopoietic hormones/cytokines and receptors regulate a wide variety of biological activities and are important in medicine. Through recent biochemical,…”
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KDR (VEGF Receptor 2) Is the Major Mediator for the Hypotensive Effect of VEGF by Li, Bing, Ogasawara, Annie K, Yang, Renhui, Wei, Wei, He, Guo-Wei, Zioncheck, Thomas F, Bunting, Stuart, de Vos, Abraham M, Jin, Hongkui

“…Vascular endothelial growth factor (VEGF) exerts vasodilation-induced hypotension as a major side effect for treatment of ischemic diseases. VEGF has 2…”
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The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 Å resolution: multiple copy flexibility and receptor binding by Muller, Yves A, Christinger, Hans W, Keyt, Bruce A, de Vos, Abraham M

“…Background: Vascular endothelial growth factor (VEGF) is an endothelial cell-specific angiogenic and vasculogenic mitogen. VEGF also plays a role in pathogenic…”
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The X-ray structure of a growth hormone-prolactin receptor complex by Somers, William, Ultsch, Mark, De Vos, Abraham M, Kossiakoff, Anthony A

“…The human pituitary hormones, growth hormone (hGH) and prolactin (hPRL), regulate a large variety of physiological processes, among which are growth and…”
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Structural Plasticity in Remodeled Protein-Protein Interface by Atwell, Shane, Ultsch, Mark, De Vos, Abraham M., Wells, James A.

“…Remodeling of the interface between human growth hormone (hGH) and the extracellular domain of its receptor was studied by deleting a critical tryptophan…”
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A Unique Zinc-Binding Site Revealed by a High-Resolution X-ray Structure of Homotrimeric Apo2L/TRAIL by Hymowitz, Sarah G, O'Connell, Mark P, Ultsch, Mark H, Hurst, Amy, Totpal, Klara, Ashkenazi, Avi, de Vos, Abraham M, Kelley, Robert F

“…Apoptosis-inducing ligand 2 (Apo2L, also called TRAIL), a member of the tumor necrosis factor (TNF) family, induces apoptosis in a variety of human tumor cell…”
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Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule by Cunningham, Brian C., Ultsch, Mark, de Vos, Abraham M., Mulkerrin, Michael G., Clauser, Karl R., Wells, James A.

“…Human growth hormone (hGH) forms a 1:2 complex with the extracellular domain of its receptor-binding protein (hGHbp) as studied by crystallization, size…”
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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex by Franklin, Matthew C, Carey, Kendall D, Vajdos, Felix F, Leahy, Daniel J, de Vos, Abraham M, Sliwkowski, Mark X

“…We have determined the 3.2 Å X-ray crystal structure of the extracellular domain of the human epidermal growth factor receptor 2 (ErbB2 or HER2) in a complex…”
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Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 å resolution by Ultsch, Mark, Lokker, Nathalie A, Godowski, Paul J, de Vos, Abraham M

“…Background: Hepatocyte growth factor (HGF) is a mitogen for hepatocytes and has also been implicated as an epithelial morphogen in tumor invasion. HGF…”
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IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding by Hymowitz, Sarah G., Filvaroff, Ellen H., Yin, JianPing, Lee, James, Cai, Liping, Risser, Philip, Maruoka, Miko, Mao, Weiguang, Foster, Jessica, Kelley, Robert F., Pan, Guohua, Gurney, Austin L., de Vos, Abraham M., Starovasnik, Melissa A.

“…The proinflammatory cytokine interleukin 17 (IL‐17) is the founding member of a family of secreted proteins that elicit potent cellular responses. We report a…”
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Convergent Solutions to Binding at a Protein-Protein Interface by DeLano, Warren L., Ultsch, Mark H., de Vos, Abraham M., Wells, James A.

“…The hinge region on the Fc fragment of human immunoglobulin G interacts with at least four different natural protein scaffolds that bind at a common site…”
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Variations on ligand-receptor complexes by de Vos, Abraham M, Wiesmann, Christian

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Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor by de Vos, Abraham M, Wiesmann, Christian, Ultsch, Mark H, Bass, Steven H

“…Nerve growth factor (NGF) is involved in a variety of processes involving signalling, such as cell differentiation and survival, growth cessation and apoptosis…”
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Triggering Cell Death: The Crystal Structure of Apo2L/TRAIL in a Complex with Death Receptor 5 by Hymowitz, Sarah G, Christinger, Hans W, Fuh, Germaine, Ultsch, Mark, O'Connell, Mark, Kelley, Robert F, Ashkenazi, Avi, de Vos, Abraham M

“…Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of…”
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Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity by Clackson, Tim, Ultsch, Mark H., Wells, James A., de Vos, Abraham M.

“…The designed G120R mutant of human growth hormone (hGH) is an antagonist and can bind only one molecule of the growth hormone receptor. We have determined the…”
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