Search Results - "De Souza, Tatiana"
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Illegal short-term rentals, regulatory enforcement and informal practices in the age of digital platforms
Published in European urban and regional studies (01-10-2024)“…This article analyses the challenges of controlling short-term rentals (STR) in an era of intermediation by digital platforms, focusing on the process of…”
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Human L‑asparaginase: Acquiring knowledge of its activation (Review)
Published in International journal of oncology (01-04-2021)“…L-asparaginase enzymes have been a vital component of acute lymphoblastic leukemia therapy for >40 years. L-asparaginase acts by depleting plasma L-asparagine,…”
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3
Circumventing the side effects of L-asparaginase
Published in Biomedicine & pharmacotherapy (01-07-2021)“…L-asparaginase is an enzyme that catalyzes the degradation of asparagine and successfully used in the treatment of acute lymphoblastic leukemia. L-asparaginase…”
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Coagulation modifiers targeting SARS-CoV-2 main protease Mpro for COVID-19 treatment: an in silico approach
Published in Memórias do Instituto Oswaldo Cruz (01-01-2020)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on viral polyprotein processing, catalysed by the main proteinase (Mpro). The…”
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Protein kinases on carbon metabolism: potential targets for alternative chemotherapies against toxoplasmosis
Published in Frontiers in cellular and infection microbiology (23-05-2023)“…The apicomplexan parasite is the causative agent of toxoplasmosis, a global disease that significantly impacts human health. The clinical manifestations are…”
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Dissecting dual specificity: Identifying key residues in L-asparaginase for enhanced acute lymphoid leukemia therapy and reduced adverse effects
Published in International journal of biological macromolecules (01-01-2024)“…L-asparaginase from Escherichia coli (EcA) has been used for the treatment of acute lymphoid leukemia (ALL) since the 1970s. Nevertheless, the enzyme has a…”
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Kinase inhibitor profile for human nek1, nek6, and nek7 and analysis of the structural basis for inhibitor specificity
Published in Molecules (Basel, Switzerland) (13-01-2015)“…Human Neks are a conserved protein kinase family related to cell cycle progression and cell division and are considered potential drug targets for the…”
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Molecular Dynamics of CYFIP2 Protein and Its R87C Variant Related to Early Infantile Epileptic Encephalopathy
Published in International journal of molecular sciences (05-08-2022)“…The CYFIP2 protein (cytoplasmic FMR1-interacting protein 2) is part of the WAVE regulatory complex (WRC). CYFIP2 was recently correlated to neurological…”
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Targeting HDACs of apicomplexans: structural insights for a better treatment
Published in Parasitology (01-06-2022)“…Aetiologic agents of diseases such as malaria and toxoplasmosis are found in representatives of the phylum Apicomplexa. Therefore, apicomplexan parasites are…”
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10
A Redox 2-Cys Mechanism Regulates the Catalytic Activity of Divergent Cyclophilins
Published in Plant physiology (Bethesda) (01-07-2013)“…The citrus (Citrus sinensis) cyclophilin CsCyp is a target of the Xanthomonas citri transcription activator-like effector PthA, required to elicit cankers on…”
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Refolding of metacaspase 5 from Trypanosoma cruzi, structural characterization and the influence of c-terminal in protein recombinant production
Published in Protein expression and purification (01-03-2022)“…Metacaspases are known to have a fundamental role in apoptosis-like, a programmed cellular death (PCD) in plants, fungi, and protozoans. The last includes…”
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PatternLab V Handles Multiplex Spectra in Shotgun Proteomic Searches and Increases Identification
Published in Journal of the American Society for Mass Spectrometry (05-04-2023)“…Complex protein mixtures typically generate many tandem mass spectra produced by different peptides coisolated in the gas phase. Widely adopted proteomic data…”
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Identification of CYFIP2 Arg87Cys Ligands via In Silico and In Vitro Approaches
Published in Biomedicines (21-02-2024)“…The advancement of next-generation sequencing has enabled the identification of specific mutations associated with early infantile epileptic encephalopathies…”
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14
Noise exposure and hypertension: investigation of a silent relationship
Published in BMC public health (03-04-2015)“…Noise is an important occupational hazard worldwide and hypertension a well-known risk factor for cardiovascular disease, which is currently the greatest cause…”
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Detection of Pestivirus A (bovine viral diarrhea virus 1) in free-living wild boars in Brazil
Published in Brazilian journal of microbiology (01-06-2021)“…Bovine viral diarrhea virus (BVDV) is a major pathogen in cattle herds. Considering the epidemiological importance of pestiviruses and the process of wild boar…”
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Proteomic changes in Trypanosoma cruzi epimastigotes treated with the proapoptotic compound PAC-1
Published in Biochimica et biophysica acta. Proteins and proteomics (01-02-2021)“…Apoptosis is a highly regulated process of cell death in metazoans. Therefore, understanding the biochemical changes associated with apoptosis-like death in…”
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Cross-linking mass spectrometry reveals structural insights of the glutamine synthetase from Leishmania braziliensis
Published in Memórias do Instituto Oswaldo Cruz (01-01-2021)“…Leishmaniasis is a neglected tropical disease caused by the parasite Leishmania braziliensis, commonly found in Brazil and associated with cutaneous and…”
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Mycoplasma hyopneumoniae in free-living wild boars in Paraná, Brazil
Published in Brazilian journal of microbiology (01-09-2021)“…This is the first study conducted in Paraná, Brazil, to investigate Mycoplasma hyopneumoniae (Mhyo) infection in free-living wild boars. Eighty-eight wild…”
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Should COVID-19 be branded to viral thrombotic fever?
Published in Memórias do Instituto Oswaldo Cruz (01-01-2021)“…Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory…”
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Mercosur and Environment: progress in promoting the Sustainable Development Goals and the 2030 Agenda
Published in Revista Brasileira de Política Internacional (01-01-2023)“…This article aims to reveal how the UN’s 2030 Agenda and the Sustainable Development Goals (SDGs), especially the environmental ones, are being incorporated…”
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