Search Results - "De Simone, Gabriele"
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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans
Published in Nature immunology (01-12-2020)“…T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained…”
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CRUSTY: a versatile web platform for the rapid analysis and visualization of high-dimensional flow cytometry data
Published in Nature communications (04-09-2023)“…Flow cytometry (FCM) can investigate dozens of parameters from millions of cells and hundreds of specimens in a short time and at a reasonable cost, but the…”
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3
Calibration of Big Bottle RAD H2O set-up for radon in water using HDPE bottles
Published in Radiation measurements (01-05-2015)“…Glass bottles are generally employed for water sampling because glass is impervious to radon and is not lost during sample storage. On the other hand, glass is…”
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Vγ9Vδ2 T-Cell Polyfunctionality Is Differently Modulated in HAART-Treated HIV Patients according to CD4 T-Cell Count
Published in PloS one (10-07-2015)“…Alteration of γδ T-cell distribution and function in peripheral blood is among the earliest defects during HIV-infection. We asked whether the polyfunctional…”
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5
Our PET project: an unlimited supply of big and small water sample vials for the assay of radon in water
Published in Journal of radioanalytical and nuclear chemistry (01-03-2016)“…RAD7 and BigBottle system has been developed, using large glass bottles, but these are fragile and awkward to carry around. In searching for a better solution,…”
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Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as a potential therapeutic target
Published in Journal of hepatology (01-11-2022)“…The landscape and function of the immune infiltrate of intrahepatic cholangiocarcinoma (iCCA), a rare, yet aggressive tumor of the biliary tract, remains…”
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7
Identification and analysis of alloreactive T lymphocytes from peripheral blood mononuclear cells
Published in Methods in cell biology (2024)“…Alloreactive T-cell responses against mismatched MHC or minor histocompatibility antigens may result in deleterious graft-versus-host disease (GVHD) and…”
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Evaluating radon loss from water during storage in standard PET, bio-based PET, and PLA bottles
Published in Radiation measurements (01-01-2016)“…Polyethylene terephthalate (PET) and polylactic acid (PLA) bottles were tested to evaluate radon loss from water during 15 days of storage. PET bottles (lower…”
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Two subsets of stem-like CD8.sup.+ memory T cell progenitors with distinct fate commitments in humans
Published in Nature immunology (01-12-2020)“…T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained…”
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10
Assessment of a low-enthalpy geothermal resource and evaluation of the natural CO2 output in the Tor di Quinto area (Rome city, Italy)
Published in Geothermics (01-02-2022)“…•Assessment of a shallow low-enthalpy geothermal resource within the city of Rome.•Evaluation by ERT profiles of top depth (∼40 m) and thickness (∼20 m) of the…”
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Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
Published in JCI insight (20-09-2018)“…Adoptive T cell transfer (ACT) immunotherapy benefits from early differentiated stem cell memory T (Tscm) cells capable of persisting in the long term and…”
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NaCl enhances CD8+ T cell effector functions in cancer immunotherapy
Published in Nature immunology (28-08-2024)“…CD8 + T cells control tumors but inevitably become dysfunctional in the tumor microenvironment. Here, we show that sodium chloride (NaCl) counteracts T cell…”
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13
Health impact of natural gas emission at Cava dei Selci residential zone (metropolitan city of Rome, Italy)
Published in Environmental geochemistry and health (01-03-2023)“…Natural gas hazard was assessed at Cava dei Selci, a residential neighbourhood of Marino (Rome) by a joint study of gas emissions and related health problems…”
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14
CXCR3 Identifies Human Naive CD8 + T Cells with Enhanced Effector Differentiation Potential
Published in The Journal of immunology (1950) (15-12-2019)“…In mice, the ability of naive T (T ) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified…”
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Soil radon survey to assess NAPL contamination from an ancient spill. Do kerosene vapors affect radon partition ?
Published in Journal of environmental radioactivity (01-05-2017)“…A soil radon-deficit survey was carried out in a site polluted with kerosene (Rome, Italy) in winter 2016 to assess the contamination due to the NAPL residual…”
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Curtailed T‐cell activation curbs effector differentiation and generates CD8+ T cells with a naturally‐occurring memory stem cell phenotype
Published in European journal of immunology (01-09-2017)“…Human T memory stem (TSCM) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long‐lived…”
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Using a multi-method approach based on soil radon deficit, resistivity, and induced polarization measurements to monitor non-aqueous phase liquid contamination in two study areas in Italy and India
Published in Environmental science and pollution research international (01-05-2018)“…Geochemical and geophysical surveys employing radon deficit, resistivity, and induced polarization (IP) measurements were undertaken on soil contaminated with…”
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HIV-specific CD8 T cells producing CCL-4 are associated with worse immune reconstitution during chronic infection
Published in Journal of acquired immune deficiency syndromes (1999) (01-07-2017)“…BACKGROUND:Immunological non response represents the Achilles heel in the combination antiretroviral treatment (cART) effectiveness, and increases risk of…”
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Laboratory simulation of recent NAPL spills to investigate radon partition among NAPL vapours and soil air
Published in Applied radiation and isotopes (01-02-2017)“…Soil radon is employed to trace residual NAPL (Non-Aqueous Phase Liquid) contamination because it is very soluble in these substances and is strongly depleted…”
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Dissecting Functional Heterogeneity in the Human CD8+ T Cell Compartment to Characterize Superior Effector Responses
Published 01-01-2020“…The constant development of technologies capable to define features at the level of single cells enabled to investigate cellular heterogeneity that was…”
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