Search Results - "De Silva, Ravindu"

Correction to: Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study by Sun, James J., Perera, Bhathika, Henley, William, Angus-Leppan, Heather, Sawhney, Indermeet, Watkins, Lance, Purandare, Kiran N., Eyeoyibo, Mogbeyiteren, Scheepers, Mark, Lines, Geraldine, Winterhalder, Robert, Ashby, Samantha, De Silva, Ravindu, Miller, Jonjo, Philpott, David E., Ashwin, Chris, Howkins, Joshua, Slater, Harriet, Medhurst, David, Shankar, Rohit

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P469: ACUTE MYELOID LEUKEMIA DRIVES BCL‐2 UPREGULATION IN NON MALIGNANT HSPCS WHICH IS TARGETED BY VENETOCLAX AND CAUSES CYTOPENIA by Fowler‐Shorten, Dominic, Maynard, Rebecca, Hampton, Katherine, Ehikioya, Martha, De Silva, Ravindu, Bowles, Kristian, Rushworth, Stuart, Hellmich, Charlotte

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P856: MULTIPLE MYELOMA DERIVED IL‐6 REDUCES FATTY ACID METABOLISM IN THE LIVER BY DOWNREGULATING CD36 AND CPT1A IN HEPATOCYTES by Egheose Ehikioya, Martha, Maynard, Rebecca, Hampton, Katherine, Hellmich, Charlotte, De Silva, Ravindu, Fowler‐Shorten, Dominic, Bowles, Kristian, Rushworth, Stuart

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P431: ACTIVATION OF MACROPHAGE STING ENHANCES PHAGOCYTOSIS OF ACUTE MYELOID LEUKAEMIA by Maynard, Rebecca, Hellmich, Charlotte, Hampton, Katherine, Moore, Jamie, Jibril, Aisha, De Silva, Ravindu, Fowler‐Shorten, Dominic, Ehikioya, Martha, Bowles, Kristian, Rushworth, Stuart

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Sting Activation in Bone Marrow Macrophages Targets AML Blasts for Phagocytosis in an ICAM-1 Dependent Mechanism by De Silva, Ravindu, Markham, Matthew, Maynard, Rebecca S, Hampton, Katherine, Hellmich, Charlotte, Fowler-Shorten, Dominic, Bowles, Kristian, Rushworth, Stuart

“…The initiation and proliferation of acute myeloid leukaemia (AML) is in part regulated by the bone marrow microenvironment. Previous work by our group has…”
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Sphingomyelinase Regulates the Release of Protumoral Mitochondria Containing-Vesicles from AML Cells by Markham, Matthew, Riley, David, Maynard, Rebecca S, Hampton, Katherine, De Silva, Ravindu, Hellmich, Charlotte, Bowles, Kristian, Rushworth, Stuart

“…Mitochondrial transfer from bone marrow stromal cells to acute myeloid leukaemia (AML) blasts is protumoral (Marlein et al., 2017; Moschoi et al., 2016) . We…”
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AML Inhibits Lipid Uptake By the Liver through an HGF/c-MET Dependent Mechanism Which Results in an Increased Supply of Free Fatty Acid to the Tumor by Maynard, Rebecca S, Hellmich, Charlotte, Hampton, Katherine, Fowler-Shorten, Dominic, Markham, Matthew, Altera, Annalisa, Flint, Thomas, De Silva, Ravindu, Beraza, Naiara, Bowles, Kristian, Rushworth, Stuart

“…Acute myeloid leukemia (AML) requires a high metabolic turnover to allow for constant expansion. We and others have previously shown that primary human AML…”
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Multiple Myeloma Induced IL-6 Reprograms Lipid Metabolism through a CD36 Dependent Mechanism by Ehikioya, Martha, Altera, Annalisa, Hampton, Katherine, Maynard, Rebecca S, Fowler-Shorten, Dominic, Hellmich, Charlotte, Bowles, Kristian, Markham, Matthew, De Silva, Ravindu, Rushworth, Stuart

“…Multiple Myeloma (MM) requires a high metabolic turnover to allow for expansion and paraprotein production. MM metabolism is complex relying on various…”
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Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression by Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta, Hampton, Katherine, Maynard, Rebecca S, De Silva, Ravindu, Fowler-Shorten, Dominic J, Mistry, Jayna J., Moore, Jamie A, Bowles, Kristian M, Rushworth, Stuart A

“…Mitochondrial damage-associated molecular patterns (mtDAMPs) include proteins, lipids, metabolites and DNA and have various context specific immunoregulatory…”
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Plasma cell–derived mtDAMPs activate the macrophage STING pathway, promoting myeloma progression by Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta E., Hampton, Katherine, Maynard, Rebecca, De Silva, Ravindu, Fowler-Shorten, Dominic J., Mistry, Jayna J., Moore, Jamie A., Bowles, Kristian M., Rushworth, Stuart A.

“…•Cell-free mtDNA is elevated in the peripheral blood and BM of patients with myeloma compared with those of healthy controls.•Myeloma-derived mtDNA remodels…”
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International Prognostic Score for Nodular Lymphocyte-Predominant Hodgkin Lymphoma by Binkley, Michael Sargent, Flerlage, Jamie E, Savage, Kerry J, Akhtar, Saad, Steiner, Raphael, Zhang, Xiao-Yin, Dickinson, Michael, Prica, Anca, Major, Ajay, Hendrickson, Peter G, Hopkins, David, Ng, Andrea, Casulo, Carla, Baron, Jonathan, Roberts, Kenneth B, Al Kendi, Jalila, Balogh, Alex, Ricardi, Umberto, Torka, Pallawi, Specht, Lena, De Silva, Ravindu, Pickard, Keir, Blazin, Lindsay J, Henry, Michael, Smith, Christine M, Halperin, Daniel, Brady, Jessica, Brennan, Bernadette, Senchenko, Maria Anatolevna, Reeves, Marie, Hoppe, Bradford S, Terezakis, Stephanie, Talaulikar, Dipti, Picardi, Marco, Kirova, Youlia, Fergusson, Paige, Hawkes, Eliza A, Lee, Denise, Doo, Nicole Wong, Barraclough, Allison, Cheah, Chan Y, Ku, Matthew, Hamad, Nada, Mutsando, Howard, Gilbertson, Michael, Marconi, Tamara, Viiala, Nicholas, Maurer, Matthew J, Eichenauer, Dennis A, Hoppe, Richard T

“…Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare cancer, and large international cooperative efforts are needed to evaluate the significance…”
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Vaccination trials on hold: malicious and low credibility content on Twitter during the AstraZeneca COVID-19 vaccine development by Horawalavithana, Sameera, De Silva, Ravindu, Weerasekara, Nipuna, Kin Wai, N G, Nabeel, Mohamed, Abayaratna, Buddhini, Elvitigala, Charitha, Wijesekera, Primal, Iamnitchi, Adriana

“…The development of COVID-19 vaccines during the global pandemic that started in 2020 was marked by uncertainty and misinformation reflected also on social…”
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A Large Scale Study and Classification of VirusTotal Reports on Phishing and Malware URLs by Choo, Euijin, Nabeel, Mohamed, De Silva, Ravindu, Yu, Ting, Khalil, Issa

“…VirusTotal (VT) provides aggregated threat intelligence on various entities including URLs, IP addresses, and binaries. It is widely used by researchers and…”
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CGraph: Graph Based Extensible Predictive Domain Threat Intelligence Platform by Daluwatta, Wathsara, De Silva, Ravindu, Kariyawasam, Sanduni, Nabeel, Mohamed, Elvitigala, Charith, De Zoysa, Kasun, Keppitiyagama, Chamath

“…Ability to effectively investigate indicators of compromise and associated network resources involved in cyber attacks is paramount not only to identify…”
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Malicious and Low Credibility URLs on Twitter during the AstraZeneca COVID-19 Vaccine Development by Horawalavithana, Sameera, De Silva, Ravindu, Nabeel, Mohamed, Elvitigala, Charitha, Wijesekara, Primal, Iamnitchi, Adriana

“…We investigate the link sharing behavior of Twitter users following the temporary halt of AstraZeneca COVID-19 vaccine development in September 2020. During…”
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