Search Results - "De Silva, Aruna"

Properties of MHC class I presented peptides that enhance immunogenicity by Calis, Jorg J A, Maybeno, Matt, Greenbaum, Jason A, Weiskopf, Daniela, De Silva, Aruna D, Sette, Alessandro, Keşmir, Can, Peters, Bjoern

“…T-cells have to recognize peptides presented on MHC molecules to be activated and elicit their effector functions. Several studies demonstrate that some…”
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Dengue virus infection elicits highly polarized CX3CR1⁺ cytotoxic CD4⁺ T cells associated with protective immunity by Weiskopf, Daniela, Bangs, Derek J., Sidney, John, Kolla, Ravi V., De Silva, Aruna D., de Silva, Aravinda M., Crotty, Shane, Peters, Bjoern, Sette, Alessandro

“…Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy…”
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An Integrated Workflow To Assess Technical and Biological Variability of Cell Population Frequencies in Human Peripheral Blood by Flow Cytometry by Burel, Julie G, Qian, Yu, Lindestam Arlehamn, Cecilia, Weiskopf, Daniela, Zapardiel-Gonzalo, Jose, Taplitz, Randy, Gilman, Robert H, Saito, Mayuko, de Silva, Aruna D, Vijayanand, Pandurangan, Scheuermann, Richard H, Sette, Alessandro, Peters, Bjoern

“…In the context of large-scale human system immunology studies, controlling for technical and biological variability is crucial to ensure that experimental data…”
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Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA by Tian, Yuan, Babor, Mariana, Lane, Jerome, Schulten, Veronique, Patil, Veena S., Seumois, Grégory, Rosales, Sandy L., Fu, Zheng, Picarda, Gaelle, Burel, Julie, Zapardiel-Gonzalo, Jose, Tennekoon, Rashika N., De Silva, Aruna D., Premawansa, Sunil, Premawansa, Gayani, Wijewickrama, Ananda, Greenbaum, Jason A., Vijayanand, Pandurangan, Weiskopf, Daniela, Sette, Alessandro, Peters, Bjoern

“…The expression of CD45RA is generally associated with naive T cells. However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after…”
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Biogeography and genetic diversity of clinical isolates of Burkholderia pseudomallei in Sri Lanka by Jayasinghearachchi, Himali S, Corea, Enoka M, Jayaratne, Kumari I, Fonseka, Regina A, Muthugama, Thilini A, Masakorala, Jayanthi, Ramasinghe, Ravija Yc, De Silva, Aruna D

“…Melioidosis is a potentially fatal infectious disease caused by Burkholderia pseudomallei and the disease is endemic in Southeast Asia and Northern Australia…”
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Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas by Montoya, Magelda, Collins, Matthew, Dejnirattisai, Wanwisa, Katzelnick, Leah C, Puerta-Guardo, Henry, Jadi, Ramesh, Schildhauer, Samuel, Supasa, Piyada, Vasanawathana, Sirijitt, Malasit, Prida, Mongkolsapaya, Juthathip, de Silva, Aruna D, Tissera, Hasitha, Balmaseda, Angel, Screaton, Gavin, de Silva, Aravinda M, Harris, Eva

“…The 4 dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies…”
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Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8⁺ T cells by Weiskopf, Daniela, Angelo, Michael A, de Azeredo, Elzinandes L, Sidney, John, Greenbaum, Jason A, Fernando, Anira N, Broadwater, Anne, Kolla, Ravi V, De Silva, Aruna D, de Silva, Aravinda M, Mattia, Kimberly A, Doranz, Benjamin J, Grey, Howard M, Shresta, Sujan, Peters, Bjoern, Sette, Alessandro

“…The role of CD8 ⁺ T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin…”
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Dengue type 1 viruses circulating in humans are highly infectious and poorly neutralized by human antibodies by Raut, Rajendra, Corbett, Kizzmekia S., Tennekoon, Rashika N., Premawansa, Sunil, Wijewickrama, Ananda, Premawansa, Gayani, Mieczkowski, Piotr, Rückert, Claudia, Ebel, Gregory D., De Silva, Aruna D., de Silva, Aravinda M.

“…The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses of humans. The interactions between DENVs and the human host that lead to asymptomatic,…”
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Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic by Bodinayake, Champica K, Tillekeratne, L Gayani, Nagahawatte, Ajith, Devasiri, Vasantha, Kodikara Arachchi, Wasantha, Strouse, John J, Sessions, October M, Kurukulasooriya, Ruvini, Uehara, Anna, Howe, Shiqin, Ong, Xin Mei, Tan, Sharon, Chow, Angelia, Tummalapalli, Praveen, De Silva, Aruna D, Østbye, Truls, Woods, Christopher W, Gubler, Duane J, Reller, Megan E

“…Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical…”
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Serological evidence of Zika virus circulation with dengue and chikungunya infections in Sri Lanka from 2017 by Abeygoonawardena, Harshi, Wijesinghe, Namal, Navaratne, Varuna, Balasuriya, Aindrala, Nguyen, Thi, Moi, Meng, De Silva, Aruna

“…Introduction: Arbovirus diseases remain a public health threat in Sri Lanka. Dengue is endemic and two outbreaks of chikungunya infections have been reported…”
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Nonclonal Burkholderia pseudomallei Population in Melioidosis Case Cluster, Sri Lanka by Jayasinghearachchi, Himali S, Francis, Vaithehi R, Sathkumara, Harindra D, Krishnananthasivam, Shivankari, Masakorala, Jayanthi, Muthugama, Thilini, De Silva, Aruna D, Corea, Enoka M

“…A melioidosis case cluster of 10 blood culture-positive patients occurred in eastern Sri Lanka after an extreme weather event. Four infections were caused by…”
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Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses by Grifoni, Alba, Moore, Eugene, Voic, Hannah, Sidney, John, Phillips, Elizabeth, Jadi, Ramesh, Mallal, Simon, De Silva, Aruna D, De Silva, Aravinda M, Peters, Bjoern, Weiskopf, Daniela, Sette, Alessandro

“…Dengue Virus (DENV) associated disease is a major public health problem. Assessment of HLA class II restricted DENV-specific responses is relevant for…”
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Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease by Tian, Yuan, Seumois, Grégory, De-Oliveira-Pinto, Luzia M., Mateus, Jose, Herrera-de la Mata, Sara, Kim, Cheryl, Hinz, Denise, Goonawardhana, N.D. Suraj, de Silva, Aruna D., Premawansa, Sunil, Premawansa, Gayani, Wijewickrama, Ananda, Balmaseda, Angel, Grifoni, Alba, Vijayanand, Pandurangan, Harris, Eva, Peters, Bjoern, Sette, Alessandro, Weiskopf, Daniela

“…Dengue virus (DENV) can cause diseases ranging from dengue fever (DF) to more severe dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Whether…”
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Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity by Grifoni, Alba, Voic, Hannah, Yu, Esther Dawen, Mateus, Jose, Yan Fung, Kai Mei, Wang, Alice, Seumois, Grégory, De Silva, Aruna D, Tennekon, Rashika, Premawansa, Sunil, Premawansa, Gayani, Tippalagama, Rashmi, Wijewickrama, Ananda, Chawla, Ashu, Greenbaum, Jason, Peters, Bjoern, Pandurangan, Vijayanand, Weiskopf, Daniela, Sette, Alessandro

“…While several lines of evidence suggest a protective role of T cells against disease associated with Dengue virus (DENV) infection, their potential…”
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Correction: Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden by Bodinayake, Champica K, Nagahawatte, Ajith DeS, Devasiri, Vasantha, Dahanayake, Niroshana J, Wijayaratne, Gaya B, Weerasinghe, Nayani P, Premamali, Madureka, Sheng, Tianchen, Nicholson, Bradley P, Ubeysekera, Harshanie A, Kurukulasooriya, Ruvini Mp, de Silva, Aruna D, Østbye, Truls, Woods, Christopher W, Tillekeratne, L Gayani

“…[This corrects the article DOI: 10.1371/journal.pntd.0010091.]…”
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Melioidosis in Sri Lanka by Corea, Enoka M, de Silva, Aruna Dharshan, Thevanesam, Vasanthi

“…Until recently, Sri Lanka was not considered a country with endemic melioidosis. However, an increasing number of cases is being reported. National…”
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Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka by Bodinayake, Champica K, Tillekeratne, L Gayani, Nagahawatte, Ajith, Devasiri, Vasantha, Kodikara Arachichi, Wasantha, Strouse, John J, Sessions, October M, Kurukulasooriya, Ruvini, Uehara, Anna, Howe, Shiqin, Ong, Xin Mei, Tan, Sharon, Chow, Angelia, Tummalapalli, Praveen, De Silva, Aruna D, Østbye, Truls, Woods, Christopher W, Gubler, Duane J, Reller, Megan E

“…Dengue is a frequent cause of acute febrile illness with an expanding global distribution. Since the 1960s, dengue in Sri Lanka has been documented primarily…”
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Burkholderia pseudomallei in soil and natural water bodies in rural Sri Lanka: A hidden threat to public health by Jayasinghearachchi, Himali S, Muthugama, Thilini A, Masakorala, Jayanthi, Kulasekara, Upeksha S, Jayaratne, Kumari, Jayatunga, D A Dasun N, De Silva, Aruna D, Corea, Enoka M

“…is the causative agent of the potentially fatal infection, melioidosis. This study provides the first evidence for the presence of in soil and water in Sri…”
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Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden by Bodinayake, Champica K, Nagahawatte, Ajith DeS, Devasiri, Vasantha, Dahanayake, Niroshana J, Wijayaratne, Gaya B, Weerasinghe, Nayani P, Premamali, Madureka, Sheng, Tianchen, Nicholson, Bradly P, Ubeysekera, Harshanie A, Kurukulasooriya, Ruvini Mp, de Silva, Aruna D, Østbye, Truls, Woods, Christopher W, Tillekeratne, L Gayani

“…Healthcare systems in dengue-endemic countries are often overburdened due to the high number of patients hospitalized according to dengue management…”
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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis by Patil, Veena S, Madrigal, Ariel, Schmiedel, Benjamin J, Clarke, James, O'Rourke, Patrick, de Silva, Aruna D, Harris, Eva, Peters, Bjoern, Seumois, Gregory, Weiskopf, Daniela, Sette, Alessandro, Vijayanand, Pandurangan

“…CD4 cytotoxic T lymphocytes (CD4-CTLs) have been reported to play a protective role in several viral infections. However, little is known in humans about the…”
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