Search Results - "De Silva, Aravinda M"

A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans by Nivarthi, Usha K., Swanstrom, Jesica, Delacruz, Matthew J., Patel, Bhumi, Durbin, Anna P., Whitehead, Steve S., Kirkpatrick, Beth D., Pierce, Kristen K., Diehl, Sean A., Katzelnick, Leah, Baric, Ralph S., de Silva, Aravinda M.

“…The four-dengue virus (DENV) serotypes infect several hundred million people annually. For the greatest safety and efficacy, tetravalent DENV vaccines are…”
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Dengue viruses are enhanced by distinct populations of serotype cross-reactive antibodies in human immune sera by de Alwis, Ruklanthi, Williams, Katherine L, Schmid, Michael A, Lai, Chih-Yun, Patel, Bhumi, Smith, Scott A, Crowe, James E, Wang, Wei-Kung, Harris, Eva, de Silva, Aravinda M

“…Dengue viruses (DENV) are mosquito-borne flaviviruses of global importance. DENV exist as four serotypes, DENV1-DENV4. Following a primary infection,…”
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Impact of pre-existing dengue immunity on human antibody and memory B cell responses to Zika by Andrade, Paulina, Gimblet-Ochieng, Ciara, Modirian, Faraz, Collins, Matthew, Cárdenas, Maritza, Katzelnick, Leah C., Montoya, Magelda, Michlmayr, Daniela, Kuan, Guillermina, Balmaseda, Angel, Coloma, Josefina, de Silva, Aravinda M., Harris, Eva

“…Little is known about enduring memory B cell (MBC) responses to Zika virus (ZIKV) and their relationship with circulating antibodies. Here we comprehensively…”
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Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus by Adams, Cameron, Carbaugh, Derek L, Shu, Bo, Ng, Thiam-Seng, Castillo, Izabella N, Bhowmik, Ryan, Segovia-Chumbez, Bruno, Puhl, Ana C, Graham, Stephen, Diehl, Sean A, Lazear, Helen M, Lok, Shee-Mei, de Silva, Aravinda M, Premkumar, Lakshmanane

“…We currently have an incomplete understanding of why only a fraction of human antibodies that bind to flaviviruses block infection of cells. Here we define the…”
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In-depth analysis of the antibody response of individuals exposed to primary dengue virus infection by de Alwis, Ruklanthi, Beltramello, Martina, Messer, William B, Sukupolvi-Petty, Soila, Wahala, Wahala M P B, Kraus, Annette, Olivarez, Nicholas P, Pham, Quang, Brien, James D, Brian, James, Tsai, Wen-Yang, Wang, Wei-Kung, Halstead, Scott, Kliks, Srisakul, Diamond, Michael S, Baric, Ralph, Lanzavecchia, Antonio, Sallusto, Federica, de Silva, Aravinda M

“…Humans who experience a primary dengue virus (DENV) infection develop antibodies that preferentially neutralize the homologous serotype responsible for…”
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Severe dengue epidemics in Sri Lanka, 2003-2006 by Kanakaratne, Nalaka, Wahala, Wahala M P B, Messer, William B, Tissera, Hasitha A, Shahani, Aruna, Abeysinghe, Nihal, de-Silva, Aravinda M, Gunasekera, Maya

“…Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past…”
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Antibody Immunity to Zika Virus among Young Children in a Flavivirus-Endemic Area in Nicaragua by Zepeda, Omar, Espinoza, Daniel O, Martinez, Evelin, Cross, Kaitlyn A, Becker-Dreps, Sylvia, de Silva, Aravinda M, Bowman, Natalie M, Premkumar, Lakshmanane, Stringer, Elizabeth M, Bucardo, Filemón, Collins, Matthew H

“…To understand the dynamics of Zika virus (ZIKV)-specific antibody immunity in children born to mothers in a flavivirus-endemic region during and after the…”
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Estimates of dengue force of infection in children in Colombo, Sri Lanka by Tam, Clarence C, Tissera, Hasitha, de Silva, Aravinda M, De Silva, Aruna Dharshan, Margolis, Harold S, Amarasinge, Ananda

“…Dengue is the most important vector-borne viral disease worldwide and a major cause of childhood fever burden in Sri Lanka, which has experienced a number of…”
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Dengue virus infection elicits highly polarized CX3CR1⁺ cytotoxic CD4⁺ T cells associated with protective immunity by Weiskopf, Daniela, Bangs, Derek J., Sidney, John, Kolla, Ravi V., De Silva, Aruna D., de Silva, Aravinda M., Crotty, Shane, Peters, Bjoern, Sette, Alessandro

“…Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy…”
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Zika virus infection enhances future risk of severe dengue disease by Katzelnick, Leah C, Narvaez, César, Arguello, Sonia, Lopez Mercado, Brenda, Collado, Damaris, Ampie, Oscarlett, Elizondo, Douglas, Miranda, Tatiana, Bustos Carillo, Fausto, Mercado, Juan Carlos, Latta, Krista, Schiller, Amy, Segovia-Chumbez, Bruno, Ojeda, Sergio, Sanchez, Nery, Plazaola, Miguel, Coloma, Josefina, Halloran, M Elizabeth, Premkumar, Lakshmanane, Gordon, Aubree, Narvaez, Federico, de Silva, Aravinda M, Kuan, Guillermina, Balmaseda, Angel, Harris, Eva

“…The Zika pandemic sparked intense interest in whether immune interactions among dengue virus serotypes 1 to 4 (DENV1 to -4) extend to the closely related Zika…”
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Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection by Collins, Matthew H, McGowan, Eileen, Jadi, Ramesh, Young, Ellen, Lopez, Cesar A, Baric, Ralph S, Lazear, Helen M, de Silva, Aravinda M

“…Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate…”
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The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients by Premkumar, Lakshmanane, Segovia-Chumbez, Bruno, Jadi, Ramesh, Martinez, David R, Raut, Rajendra, Markmann, Alena, Cornaby, Caleb, Bartelt, Luther, Weiss, Susan, Park, Yara, Edwards, Caitlin E, Weimer, Eric, Scherer, Erin M, Rouphael, Nadine, Edupuganti, Srilatha, Weiskopf, Daniela, Tse, Longping V, Hou, Yixuan J, Margolis, David, Sette, Alessandro, Collins, Matthew H, Schmitz, John, Baric, Ralph S, de Silva, Aravinda M

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a pandemic of severe respiratory illness…”
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Reciprocal Expression of ospA and ospC in Single Cells of Borrelia burgdorferi by SRIVASTAVA, Siddharth Y, DE SILVA, Aravinda M

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Longitudinal Analysis of Antibody Cross-neutralization Following Zika Virus and Dengue Virus Infection in Asia and the Americas by Montoya, Magelda, Collins, Matthew, Dejnirattisai, Wanwisa, Katzelnick, Leah C, Puerta-Guardo, Henry, Jadi, Ramesh, Schildhauer, Samuel, Supasa, Piyada, Vasanawathana, Sirijitt, Malasit, Prida, Mongkolsapaya, Juthathip, de Silva, Aruna D, Tissera, Hasitha, Balmaseda, Angel, Screaton, Gavin, de Silva, Aravinda M, Harris, Eva

“…The 4 dengue virus serotypes (DENV1-4) and Zika virus (ZIKV) are related mosquito-borne flaviviruses of major importance globally. While monoclonal antibodies…”
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Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8⁺ T cells by Weiskopf, Daniela, Angelo, Michael A, de Azeredo, Elzinandes L, Sidney, John, Greenbaum, Jason A, Fernando, Anira N, Broadwater, Anne, Kolla, Ravi V, De Silva, Aruna D, de Silva, Aravinda M, Mattia, Kimberly A, Doranz, Benjamin J, Grey, Howard M, Shresta, Sujan, Peters, Bjoern, Sette, Alessandro

“…The role of CD8 ⁺ T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin…”
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A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins by Fibriansah, Guntur, Tan, Joanne L., Smith, Scott A., de Alwis, Ruklanthi, Ng, Thiam-Seng, Kostyuchenko, Victor A., Jadi, Ramesh S., Kukkaro, Petra, de Silva, Aravinda M., Crowe, James E., Lok, Shee-Mei

“…Dengue virus (DENV) infects ~400 million people annually. There is no licensed vaccine or therapeutic drug. Only a small fraction of the total DENV-specific…”
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Dengue type 1 viruses circulating in humans are highly infectious and poorly neutralized by human antibodies by Raut, Rajendra, Corbett, Kizzmekia S., Tennekoon, Rashika N., Premawansa, Sunil, Wijewickrama, Ananda, Premawansa, Gayani, Mieczkowski, Piotr, Rückert, Claudia, Ebel, Gregory D., De Silva, Aruna D., de Silva, Aravinda M.

“…The four dengue virus (DENV) serotypes are mosquito-borne flaviviruses of humans. The interactions between DENVs and the human host that lead to asymptomatic,…”
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The human antibody response to dengue virus infection by Wahala, Wahala M P B, Silva, Aravinda M de

“…Dengue viruses (DENV) are the causative agents of dengue fever (DF) and dengue hemorrhagic fever (DHF). Here we review the current state of knowledge about the…”
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Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions by de Alwis, Ruklanthi, Smith, Scott A, Olivarez, Nicholas P, Messer, William B, Huynh, Jeremy P, Wahala, Wahala M. P. B, White, Laura J, Diamond, Michael S, Baric, Ralph S, Crowe, James E., Jr, de Silva, Aravinda M

“…Dengue is a mosquito-borne flavivirus that is spreading at an unprecedented rate and has developed into a major health and economic burden in over 50…”
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Antigenic Variation of the Dengue Virus 2 Genotypes Impacts the Neutralization Activity of Human Antibodies in Vaccinees by Martinez, David R., Yount, Boyd, Nivarthi, Usha, Munt, Jennifer E., Delacruz, Matthew J., Whitehead, Stephen S., Durbin, Anna P., de Silva, Aravinda M., Baric, Ralph S.

“…Dengue virus (DENV) infects an estimated 390 million people each year worldwide. As tetravalent DENV vaccines have variable efficacy against DENV serotype 2…”
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