Search Results - "De Serrano, Vesna S."

Involvement of Tyrosine-76 of the Kringle 2 Domain of Tissue-Type Plasminogen Activator in Its Thermal Stability and Its .omega.-Amino Acid Ligand Binding Site by De Serrano, Vesna S, Castellino, Francis J

“…A series of conservative and radical mutations have been made at an aromatic residue, Y76, of the isolated kringle 2 domain of tissue-type plasminogen…”
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Specific anionic residues of the recombinant kringle 2 domain of tissue-type plasminogen activator that are responsible for stabilization of its interaction with .omega.-amino acid ligands by De Serrano, Vesna S, Castellino, Francis J

“…The involvement of specific aspartic acid (D) and glutamic acid (E) residues of the recombinant (r) kringle 2 (K2) domain of tissue-type plasminogen activator…”
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The cationic locus on the recombinant kringle 2 domain of tissue-type plasminogen activator that stabilizes its interaction with .omega.-amino acids by De Serrano, Vesna S, Castellino, Francis J

“…The properties of the cationic locus within the recombinant (r) kringle 2 domain (residues 180-261) of tissue-type plasminogen activator ([K2tPA]) that are…”
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Role of tryptophan-74 of the recombinant kringle 2 domain of tissue-type plasminogen activator in its .omega.-amino acid binding properties by De Serrano, Vesna S, Castellino, Francis J

“…The role of W74 in stabilization of the binding of omega-amino acids to the recombinant (r) kringle 2 domain (residues 180-261) of tissue-type plasminogen…”
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Role of the Strictly Conserved Tryptophan-25 Residue in the Stabilization of the Structure and in the Ligand Binding Properties of the Kringle 2 Domain of Tissue-Type Plasminogen Activator by De Serrano, Vesna S, Castellino, Francis J

“…The involvement of the strictly conserved tryptophan-25 (W25) residue in the structural stability and omega-amino acid ligand binding properties of the…”
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Direct identification of lysine-33 as the principal cationic center of the omega-amino acid binding site of the recombinant kringle 2 domain of tissue-type plasminogen activator by De Serrano, V S, Sehl, L C, Castellino, F J

“…We have generated site-specific mutants of the kringle 2 domain of tissue-type plasminogen activator [( K2tPA]) in order to identify directly the cationic…”
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Structural determinants of the noncatalytic chain of tissue-type plasminogen activator that modulate its association rate with plasminogen activator inhibitor-1 by DE SERRANO, V. S, CASTELLINO, F. J

“…In order to identify the regions of recombinant (r) tissue plasminogen activator (tPA) that mediate its kinetically relevant interaction with r-plasminogen…”
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Roles for Chloride Ion and Fibrinogen in the Activation of [Glu1]Plasminogen in Human Plasma by Gaffney, Patrick J., Urano, Tetsumei, De Serrano, Vesna S., Mahmoud-Alexandroni, Maher, Metzger, Alan R., Castellino, Francis J.

“…Using two-dimensional immunoelectrophoresis and an antibody to α 2-antiplasmin, we assessed the plasmin generated in serum under different conditions as the…”
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Influence of various structural domains of fibrinogen and fibrin on the potentiation of plasminogen activation by recombinant tissue plasminogen activator by de Serrano, V S, Urano, T, Gaffney, P J, Castellino, F J

“…Fibrinogen, fibrin, and related fragments have varying stimulatory effects on the initial rate of the activation of human plasminogen ([ Glu1]Pg) by…”
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