Search Results - "De Santis, Riccardo"
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Self-organization of human dorsal-ventral forebrain structures by light induced SHH
Published in Nature communications (19-11-2021)“…Organizing centers secrete morphogens that specify the emergence of germ layers and the establishment of the body’s axes during embryogenesis. While…”
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Genotyping of Bacillus anthracis strains based on automated capillary 25-loci multiple locus variable-number tandem repeats analysis
Published in BMC microbiology (06-04-2006)“…The genome of Bacillus anthracis, the etiological agent of anthrax, is highly monomorphic which makes differentiation between strains difficult. A Multiple…”
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FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons
Published in Nature communications (30-03-2017)“…The RNA-binding protein FUS participates in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS)…”
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Procrustes-based distances for exploring between-matrices similarity
Published in Statistical methods & applications (01-09-2023)“…The statistical shape analysis called Procrustes analysis minimizes the Frobenius distance between matrices by similarity transformations. The method returns a…”
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FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis
Published in Stem cell reports (14-11-2017)“…The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective…”
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ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons
Published in Disease models & mechanisms (01-07-2015)“…Patient-derived induced pluripotent stem cells (iPSCs) provide an opportunity to study human diseases mainly in those cases for which no suitable model systems…”
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Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis
Published in Cell reports (Cambridge) (25-06-2019)“…Amyotrophic lateral sclerosis (ALS) has been genetically linked to mutations in RNA-binding proteins (RBPs), including FUS. Here, we report the RNA interactome…”
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Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector
Published in Stem cell research (01-05-2018)“…Human pluripotent stem cells (PSCs) are widely used for in vitro disease modeling. One of the challenges in the field is represented by the ability of…”
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Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function
Published in Journal of cell science (01-08-2017)“…Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation…”
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SARS-CoV-2 Inactivation in Aerosol by Means of Radiated Microwaves
Published in Viruses (27-06-2023)“…Coronaviruses are a family of viruses that cause disease in mammals and birds. In humans, coronaviruses cause infections on the respiratory tract that can be…”
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Co-circulation of Dengue and Chikungunya Viruses, Al Hudaydah, Yemen, 2012
Published in Emerging infectious diseases (01-08-2014)“…We investigated 400 cases of dengue-like illness in persons hospitalized during an outbreak in Al Hudaydah, Yemen, in 2012. Overall, 116 dengue and 49…”
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Reply to Taylor et al. Comment on “Manna et al. SARS-CoV-2 Inactivation in Aerosol by Means of Radiated Microwaves. Viruses 2023, 15, 1443”
Published in Viruses (18-10-2023)“…SARS-CoV-2 is inactivated in aerosol (its primary mode of transmission) by means of radiated microwaves at frequencies that have been experimentally…”
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Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19
Published in Biology direct (16-10-2024)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search…”
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Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation
Published in eLife (22-04-2022)“…The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon…”
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Antibodies Induced by Smallpox Vaccination after at Least 45 Years Cross-React with and In Vitro Neutralize Mpox Virus: A Role for Polyclonal B Cell Activation?
Published in Viruses (01-04-2024)“…To evaluate whether antibodies specific for the vaccinia virus (VV) are still detectable after at least 45 years from immunization. To confirm that VV-specific…”
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Have Diagnostics, Therapies, and Vaccines Made the Difference in the Pandemic Evolution of COVID-19 in Comparison with "Spanish Flu"?
Published in Pathogens (Basel) (23-06-2023)“…In 1918 many countries, but not Spain, were fighting World War I. Spanish press could report about the diffusion and severity of a new infection without…”
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Huntingtin CAG-expansion mutation results in a dominant negative effect
Published in Frontiers in cell and developmental biology (01-09-2023)“…Introduction: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene ( HTT…”
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State of the Art on the SARS-CoV-2 Toolkit for Antigen Detection: One Year Later
Published in Biosensors (Basel) (31-08-2021)“…The recent global events of COVID-19 in 2020 have alerted the world to the risk of viruses and their impacts on human health, including their impacts in the…”
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Differentiation of control and ALS mutant human iPSCs into functional skeletal muscle cells, a tool for the study of neuromuscolar diseases
Published in Stem cell research (01-07-2016)“…Amyotrophic Lateral Sclerosis (ALS) is a severe and fatal neurodegenerative disease characterized by progressive loss of motoneurons, muscle atrophy and…”
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