Search Results - "De Robertis, E.M."

Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field by Reversade, Bruno, De Robertis, E.M.

“…Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We…”
Get full text

Embryonic Dorsal-Ventral Signaling: Secreted Frizzled-Related Proteins as Inhibitors of Tolloid Proteinases by Lee, Hojoon X., Ambrosio, Andrea L., Reversade, Bruno, De Robertis, E.M.

“…Here we report an unexpected role for the secreted Frizzled-related protein (sFRP) Sizzled/Ogon as an inhibitor of the extracellular proteolytic reaction that…”
Get full text

Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad by Eivers, Edward, Demagny, Hadrien, De Robertis, E.M

“…Abstract BMPs pattern the dorsal–ventral axis of vertebrate embryos. Smad1/5/8 transduces the BMP signal, and receives phosphorylation inputs from both MAPK…”
Get full text

Protocol for Probing Regulated Lysosomal Activity and Function in Living Cells by Albrecht, L.V., Tejeda-Muñoz, N., De Robertis, E.M.

“…Lysosomes are the catabolic center of the cell. Limitations of many lysosomal tracers include low specificity and lack of reliable physiological readouts for…”
Get full text

Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation by Kuroda, Hiroki, Fuentealba, Luis, Ikeda, Atsushi, Reversade, Bruno, De Robertis, E M

“…Xenopus embryonic ectodermal cells dissociated for three or more hours differentiate into neural tissue instead of adopting their normal epidermal fate. This…”
Get full text

Spemann’s organizer and the self-regulation of embryonic fields by De Robertis, E.M.

“…Embryos and developing organs have the remarkable ability of self-regenerating after experimental manipulations. In the Xenopus blastula half-embryos can…”
Get full text

Chordin Is Required for the Spemann Organizer Transplantation Phenomenon in Xenopus Embryos by Oelgeschläger, Michael, Kuroda, Hiroki, Reversade, Bruno, De Robertis, E.M.

“…We analyzed the Chordin requirement in Xenopus development. Targeting of both chordin Xenopus laevis pseudoalleles with morpholino antisense oligomers (Chd-MO)…”
Get full text

Neural and Head Induction by Insulin-like Growth Factor Signals by Pera, Edgar M., Wessely, Oliver, Li, Su-Yu, De Robertis, E.M.

“…Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs…”
Get full text

Development of the vertebral morphogenetic field in the mouse: Interactions between Crossveinless-2 and Twisted Gastrulation by Zakin, Lise, Metzinger, Carrie A., Chang, Ellen Y., Coffinier, Catherine, De Robertis, E.M.

“…Crossveinless-2 (Cv2), Twisted Gastrulation (Tsg) and Chordin (Chd) are components of an extracellular biochemical pathway that regulates Bone Morphogenetic…”
Get full text

Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for brain formation in Xenopus laevis embryos by Ishibashi, Hideyuki, Matsumura, Noriko, Hanafusa, Hiroshi, Matsumoto, Kunihiro, Robertis, E.M. De, Kuroda, Hiroki

“…The blastula Chordin- and Noggin-expressing (BCNE) center located in the dorsal animal region of the Xenopus blastula embryo contains both prospective anterior…”
Get full text

On the function of BMP‐4 in patterning the marginal zone of the Xenopus embryo by Fainsod, A., Steinbeisser, H., De Robertis, E.M.

“…Bone morphogenetic protein 4 (BMP‐4) is expressed in the ventral marginal zone of the gastrulating embryo. At late gastrula stage this gene is expressed in the…”
Get full text

Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays by Wessely, Oliver, Kim, James I, Geissert, Douglas, Tran, Uyen, De Robertis, E M

“…The understanding of vertebrate development has greatly benefited from the study of gastrulation in the Xenopus embryo. Over the years, the molecular…”
Get full text

Overexpression of the Xenopus Tight-Junction Protein Claudin Causes Randomization of the Left–Right Body Axis by Brizuela, Brenda J, Wessely, Oliver, De Robertis, E.M

“…This study presents Xenopus claudin (Xcla), a tight-junction protein that is abundantly expressed in eggs and neuroectodermal precursors during early…”
Get full text

Neural Plate Patterning by Secreted Signals by Wessely, Oliver, De Robertis, E.M

“…The patterning of the CNS relies on the interaction of multiple signaling molecules such as Sonic Hedgehog, Wnts, and BMPs and their antagonists Chordin and…”
Get full text

Evo-Devo: Variations on Ancestral Themes by De Robertis, E.M.

“…Most animals evolved from a common ancestor, Urbilateria, which already had in place the developmental genetic networks for shaping body plans. Comparative…”
Get full text

Extracellular regulation of BMP signaling by Zakin, Lise, De Robertis, E.M.

“…In the developing organism, cells differentiate, divide and die as part of groups of hundreds or thousands of cells called ‘morphogenetic fields’. Fields have…”
Get full text

A homeobox-containing marker of posterior neural differentiation shows the importance of predetermination in neural induction by Sharpe, C R, Fritz, A, De Robertis, E M, Gurdon, J B

“…A homeobox sequence has been used to isolate a new Xenopus cDNA, named XIHbox6. A short probe from this gene serves as an early marker of posterior neural…”
Get more information

Activity-Induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2β and p38 MAP Kinases by Yasuda, Shin, Tanaka, Hidekazu, Sugiura, Hiroko, Okamura, Ko, Sakaguchi, Taiki, Tran, Uyen, Takemiya, Takako, Mizoguchi, Akira, Yagita, Yoshiki, Sakurai, Takeshi, De Robertis, E.M., Yamagata, Kanato

“…Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin…”
Get full text

A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1 by Pera, Edgar M, De Robertis, E.M

“…To determine the spectrum of secreted proteins that are present in the extracellular space of early Xenopus embryos, a direct secretion screen was performed…”
Get full text

Asymmetric mitosis: Unequal segregation of proteins destined for degradation by Fuentealba, Luis C, Eivers, Edward, Geissert, Douglas, Taelman, Vincent, De Robertis, E.M

“…Mitotic cell division ensures that two daughter somatic cells inherit identical genetic material. Previous work has shown that signaling by the Smad1…”
Get full text