Search Results - "De Pinto, Vito"
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Is the secret of VDAC Isoforms in their gene regulation? Characterization of human VDAC genes expression profile, promoter activity, and transcriptional regulators
Published in International journal of molecular sciences (01-10-2020)“…VDACs (voltage-dependent anion-selective channels) are pore-forming proteins of the outer mitochondrial membrane, whose permeability is primarily due to VDACs'…”
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2
Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis
Published in Cell research (01-12-2009)“…Voltage-dependent anion channel (VDAC)I is the main channel of the mitochondrial outer membrane (MOM) and it has been proposed to be part of the permeability…”
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3
Renaissance of VDAC: New Insights on a Protein Family at the Interface between Mitochondria and Cytosol
Published in Biomolecules (Basel, Switzerland) (15-01-2021)“…It has become impossible to review all the existing literature on Voltage-Dependent Anion selective Channel (VDAC) in a single article. A real Renaissance of…”
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4
Role of cysteines in mammalian VDAC isoforms' function
Published in Biochimica et biophysica acta (01-08-2016)“…In this mini-review, we analyze the influence of cysteines in the structure and activity of mitochondrial outer membrane mammalian VDAC isoforms. The three…”
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5
VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis
Published in Frontiers in chemistry (06-04-2018)“…Cancer and neurodegeneration are different classes of diseases that share the involvement of mitochondria in their pathogenesis. Whereas the high glycolytic…”
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6
VDAC as a Cellular Hub: Docking Molecules and Interactions
Published in International journal of molecular sciences (01-04-2023)“…The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-soluble metabolites and ions across the mitochondrial outer membrane…”
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7
Molecular and functional characterization of VDAC2 purified from mammal spermatozoa
Published in Bioscience reports (22-07-2009)“…VDAC (voltage-dependent anion channel) is the pore-forming protein located in the outer mitochondrial membrane. In higher eukaryotes, three genes encode VDAC…”
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8
Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction
Published in The Journal of biological chemistry (25-11-2016)“…Apoptosis is thought to play a critical role in several pathological processes, such as neurodegenerative diseases (i.e. Parkinson's and Alzheimer's diseases)…”
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VDAC Genes Expression and Regulation in Mammals
Published in Frontiers in physiology (05-08-2021)“…VDACs are pore-forming proteins, coating the mitochondrial outer membrane, and playing the role of main regulators for metabolites exchange between cytosol and…”
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10
Voltage-dependent anion-selective channel (VDAC) in the plasma membrane
Published in FEBS letters (03-05-2010)“…Voltage-dependent anion channels (VDACs) have originally been characterized as mitochondrial porins. Starting in the late 1980s, however, evidence began to…”
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11
Editorial: VDAC Structure and Function: An Up-to-Date View
Published in Frontiers in physiology (04-04-2022)Get full text
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12
Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress
Published in Redox biology (01-05-2022)“…Unraveling the role of VDAC3 within living cells is challenging and still requires a definitive answer. Unlike VDAC1 and VDAC2, the outer mitochondrial…”
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13
VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology
Published in Frontiers in oncology (23-12-2016)“…VDAC3 is the least known isoform of the mammalian voltage-dependent anion selective channels of the outer mitochondrial membrane. It has been recently shown…”
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14
Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast
Published in Cellular and molecular life sciences : CMLS (01-08-2020)“…The Voltage-Dependent Anion-selective Channel (VDAC) is the pore-forming protein of mitochondrial outer membrane, allowing metabolites and ions exchanges. In…”
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15
Charged residues distribution modulates selectivity of the open state of human isoforms of the voltage dependent anion-selective channel
Published in PloS one (01-08-2014)“…Voltage Dependent Anion-selective Channels (VDACs) are pore-forming proteins located in the outer mitochondrial membrane. They are responsible for the access…”
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16
Characterization of human VDAC isoforms: A peculiar function for VDAC3?
Published in Biochimica et biophysica acta (01-06-2010)“…VDACs are a family of pore-forming proteins mainly located in the mitochondrial outer membrane. In mammals three isoforms exist. In this work we review the…”
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The voltage-dependent anion selective channel 1 (VDAC1) topography in the mitochondrial outer membrane as detected in intact cell
Published in PloS one (06-12-2013)“…Voltage-Dependent Anion selective Channel maintains the permeability of the outer mitochondrial membrane and is relevant in bioenergetic metabolism and…”
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18
Post-translational modifications of VDAC1 and VDAC2 cysteines from rat liver mitochondria
Published in Biochimica et biophysica acta. Bioenergetics (01-09-2018)“…VDACs three isoforms (VDAC1, VDAC2, VDAC3) are integral proteins of the outer mitochondrial membrane whose primary function is to permit the communication and…”
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VDAC1 Knockout Affects Mitochondrial Oxygen Consumption Triggering a Rearrangement of ETC by Impacting on Complex I Activity
Published in International journal of molecular sciences (01-02-2023)“…Voltage-Dependent Anion-selective Channel isoform 1 (VDAC1) is the most abundant isoform of the outer mitochondrial membrane (OMM) porins and the principal…”
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20
A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs)
Published in International journal of molecular sciences (21-02-2020)“…The voltage-dependent anion-selective channels (VDACs), which are also known as eukaryotic porins, are pore-forming proteins, which allow for the passage of…”
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