Search Results - "De Paulis, Tomas"

Quinides of roasted coffee enhance insulin action in conscious rats by Shearer, Jane, Farah, Adriana, de Paulis, Tomas, Bracy, Deanna P, Pencek, R Richard, Graham, Terry E, Wasserman, David H

“…Consumption of large amounts of coffee has been shown to decrease the incidence of type 2 diabetes. However, the specific compounds and mechanisms responsible…”
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Three centuries on the science of coffee authenticity control by Ferreira, Thiago, Galluzzi, Leticia, de Paulis, Tomas, Farah, Adriana

“…[Display omitted] •Over the past centuries coffee has gone through many types of adulteration;•Barley, coffee by-products, corn and chicory are the most used…”
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Comprehensive analysis of major and minor chlorogenic acids and lactones in economically relevant Brazilian coffee cultivars by Perrone, Daniel, Farah, Adriana, Donangelo, Carmen M., de Paulis, Tomas, Martin, Peter R.

“…Coffee is the most consumed beverage in the world and a significant source of phenolic compounds, particularly chlorogenic acids (CGA). During coffee roasting,…”
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Effect of Roasting on the Formation of Chlorogenic Acid Lactones in Coffee by Farah, Adriana, de Paulis, Tomas, Trugo, Luiz C, Martin, Peter R

“…Of all plant constituents, coffee has one of the highest concentrations of chlorogenic acids. When roasting coffee, some of these are transformed into…”
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Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4 by Niswender, Colleen M, Johnson, Kari A, Weaver, C David, Jones, Carrie K, Xiang, Zixiu, Luo, Qingwei, Rodriguez, Alice L, Marlo, Joy E, de Paulis, Tomas, Thompson, Analisa D, Days, Emily L, Nalywajko, Tasha, Austin, Cheryl A, Williams, Michael Baxter, Ayala, Jennifer E, Williams, Richard, Lindsley, Craig W, Conn, P Jeffrey

“…Parkinson's disease (PD) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia…”
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Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice by Galici, Ruggero, Jones, Carrie K, Hemstapat, Kamondanai, Nong, Yi, Echemendia, Nicholas G, Williams, Lilly C, de Paulis, Tomas, Conn, P Jeffrey

“…Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide a novel approach for the…”
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Substituent Effects of N-(1,3-Diphenyl-1H-pyrazol-5-yl)benzamides on Positive Allosteric Modulation of the Metabotropic Glutamate-5 Receptor in Rat Cortical Astrocytes by de Paulis, Tomas, Hemstapat, Kamondanai, Chen, Yelin, Zhang, Yongqin, Saleh, Samir, Alagille, David, Baldwin, Ronald M, Tamagnan, Gilles D, Conn, P. Jeffrey

“…CDPPB [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide] was recently described as the first centrally active, positive allosteric modulator of rat and human…”
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Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses by Chen, Yelin, Nong, Yi, Goudet, Cyril, Hemstapat, Kamondanai, de Paulis, Tomas, Pin, Jean-Philippe, Conn, P Jeffrey

“…Exciting advances have been made in the discovery of selective positive allosteric modulators of the metabotropic glutamate receptor (mGluR) mGluR5. These…”
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A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators by Hemstapat, Kamondanai, de Paulis, Tomas, Chen, Yelin, Brady, Ashley E, Grover, Vandana K, Alagille, David, Tamagnan, Gilles D, Conn, P Jeffrey

“…We recently reported a novel class of compounds, represented by 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CD-PPB), that act as positive allosteric…”
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Pharmacological characterization of morphine-6-sulfate and codeine-6-sulfate by Zuckerman, Amy, Bolan, Elizabeth, de Paulis, Tomas, Schmidt, Dennis, Spector, Sydney, Pasternak, Gavril W.

“…Morphine-6-sulfate (M6S) and codeine-6-sulfate (C6S) are mu-selective opiates which have been isolated from brain. M6S is an effective analgesic, with a…”
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Distribution of Major Chlorogenic Acids and Related Compounds in Brazilian Green and Toasted Ilex paraguariensis (Maté) Leaves by Lima, Juliana de Paula, Farah, Adriana, King, Benjamin, de Paulis, Tomas, Martin, Peter R

“…Ilex paraguariensis (maté) is one of the best sources of chlorogenic acids (CGA) in nature. When leaves are toasted, some isomers are partly transformed into…”
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Sterically hindered 5,11-dicarbo analogs of clozapine as potential chiral antipsychotic agents by Rupard, J. Howard, De Paulis, Tomas, Janowsky, Aaron, Smith, Howard E

“…Sterically hindered 5,11-dicarbo analogues of clozapine were prepared as potential chiral antipsychotic agents, with the possibility that for a particular…”
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Characterization of (S)-des-4-amino-3-[125I]iodozacopride ([125I]DAIZAC), a selective high-affinity radioligand for 5-hydroxytryptamine3 receptors by Hewlett, W A, Trivedi, B L, Zhang, Z J, de Paulis, T, Schmidt, D E, Lovinger, D M, Ansari, M S, Ebert, M H

“…The 5-hydroxytryptamine(HT)3 receptor subtype is present in the central nervous system (CNS) in low abundance, and few selective radiolabeled antagonists with…”
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Drug evaluation: Vilazodone--a combined SSRI and 5-HT1A partial agonist for the treatment of depression by de Paulis, Tomas

“…Vilazodone is a combined selective serotonin reuptake inhibitor (SSRI) and a 5-HT(1A) receptor partial agonist that is being developed by Clinical Data Inc for…”
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Diferuloylquinide is converted to diferuloylquinic acid and other phenolic compounds during digestion and/or metabolism in rats by Farah, Adriana, Shearer, Jane, De Paulis, Tomas

“…Abstract only Chlorogenic acids are esters of hydroxycinnamic acids with quinic acid. Coffee is one of the main food sources of chlorogenic acids and during…”
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( S)-4-amino-5-chloro-3-iodo-2-methoxy- N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptor by de Paulis, Tomas, Trivedi, Bakula L., Zhang, Zhang-Jin, Schmidt, Dennis E., Ebert, Michael H., Hewlett, William A.

“…TRIZAC is one of the most potent 5-HT-3 receptor antagonist reported to date, having 20-fold higher affinity than ( S)-5-todozacopride. This high affinity ( K…”
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Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study by Hoegberg, Thomas, De Paulis, Tomas, Johansson, Lars, Kumar, Yatendra, Hall, Haakan, Oegren, Sven Ove

“…(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide (6) and some related compounds, i.e. the R isomer 7, the 3-hydroxy analogue 8, the…”
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Evaluation of 5-[18F]fluoropropylepidepride as a potential PET radioligand for imaging dopamine D2 receptors by Kessler, R M, Votaw, J R, de Paulis, T, Bingham, D R, Ansari, M S, Mason, N S, Holburn, G, Schmidt, D E, Votaw, D B, Manning, R G

“…This study evaluated the utility of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2,3 - dimethoxybenzamide ([18F]fluorpropylepidepride),…”
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Antioxidant effects of dihydrocaffeic acid in human EA.hy926 endothelial cells by Huang, Junjun, de Paulis, Tomas, May, James M.

“…Dihydrocaffeic acid (DHCA) is a metabolite of caffeic acid with potent antioxidant properties. Since DHCA has been detected in human plasma following coffee…”
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Potential neuroleptic agents. 4. Chemistry, behavioral pharmacology, and inhibition of [3H]spiperone binding of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamides by De Paulis, Tomas, Kumar, Yatendra, Johansson, Lars, Raemsby, Sten, Hall, Haakan, Saellemark, Maria, Aengeby-Moeller, Kristina, Oegren, Sven Ove

“…A series of 3,5-disubstituted N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxysalicylamides was synthesized, starting from the 2,6-dimethoxybenzoic acids, by…”
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