Search Results - "De Pater, Emma"

Zebrafish macrophage developmental arrest underlies depletion of microglia and reveals Csf1r-independent metaphocytes by Kuil, Laura E, Oosterhof, Nynke, Ferrero, Giuliano, Mikulášová, Tereza, Hason, Martina, Dekker, Jordy, Rovira, Mireia, van der Linde, Herma C, van Strien, Paulina Mh, de Pater, Emma, Schaaf, Gerben, Bindels, Erik Mj, Wittamer, Valerie, van Ham, Tjakko J

“…Macrophages derive from multiple sources of hematopoietic progenitors. Most macrophages require colony-stimulating factor 1 receptor (CSF1R), but some…”
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Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia by Olofsen, Patricia A., Fatrai, Szabolcs, van Strien, Paulina M.H., Obenauer, Julia C., de Looper, Hans W.J., Hoogenboezem, Remco M., Erpelinck-Verschueren, Claudia A.J., Vermeulen, Michael P.W.M., Roovers, Onno, Haferlach, Torsten, Jansen, Joop H., Ghazvini, Mehrnaz, Bindels, Eric M.J., Schneider, Rebekka K., de Pater, Emma M., Touw, Ivo P.

“…Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern…”
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Gata2 is required for HSC generation and survival by de Pater, Emma, Kaimakis, Polynikis, Vink, Chris S, Yokomizo, Tomomasa, Yamada-Inagawa, Tomoko, van der Linden, Reinier, Kartalaei, Parham Solaimani, Camper, Sally A, Speck, Nancy, Dzierzak, Elaine

“…Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC) generation is of particular importance for current hematopoietic…”
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From Basic Biology to Patient Mutational Spectra of GATA2 Haploinsufficiencies: What Are the Mechanisms, Hurdles, and Prospects of Genome Editing for Treatment by Koyunlar, Cansu, de Pater, Emma

“…Inherited bone marrow failure syndromes (IBMFS) are monogenetic disorders that result in a reduction of mature blood cell formation and predisposition to…”
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Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart by de Pater, Emma, Clijsters, Linda, Marques, Sara R., Lin, Yi-Fan, Garavito-Aguilar, Zayra V., Yelon, Deborah, Bakkers, Jeroen

“…Amongst animal species, there is enormous variation in the size and complexity of the heart, ranging from the simple one-chambered heart of Ciona intestinalis…”
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Identification and functional characterization of cardiac pacemaker cells in zebrafish by Tessadori, Federico, van Weerd, Jan Hendrik, Burkhard, Silja B, Verkerk, Arie O, de Pater, Emma, Boukens, Bastiaan J, Vink, Aryan, Christoffels, Vincent M, Bakkers, Jeroen

“…In the mammalian heart a conduction system of nodes and conducting cells generates and transduces the electrical signals evoking myocardial contractions…”
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Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation by Solaimani Kartalaei, Parham, Yamada-Inagawa, Tomoko, Vink, Chris S, de Pater, Emma, van der Linden, Reinier, Marks-Bluth, Jonathon, van der Sloot, Anthon, van den Hout, Mirjam, Yokomizo, Tomomasa, van Schaick-Solernó, M Lucila, Delwel, Ruud, Pimanda, John E, van IJcken, Wilfred F J, Dzierzak, Elaine

“…Hematopoietic stem cells (HSCs) are generated via a natural transdifferentiation process known as endothelial to hematopoietic cell transition (EHT). Because…”
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The role of GATA2 in adult hematopoiesis and cell fate determination by Peters, Iris J A, de Pater, Emma, Zhang, Wei

“…The correct maintenance and differentiation of hematopoietic stem cells (HSC) in bone marrow is vital for the maintenance and operation of the human blood…”
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Bloody Zebrafish: Novel Methods in Normal and Malignant Hematopoiesis by de Pater, Emma, Trompouki, Eirini

“…Hematopoiesis is an optimal system for studying stem cell maintenance and lineage differentiation under physiological and pathological conditions. In…”
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Truncated CSF3 receptors induce pro‐inflammatory responses in severe congenital neutropenia by Olofsen, Patricia A., Bosch, Dennis A., Looper, Hans W. J., Strien, Paulina M. H., Hoogenboezem, Remco M., Roovers, Onno, Velden, Vincent H. J., Bindels, Eric M. J., De Pater, Emma M., Touw, Ivo P.

“…Summary Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic…”
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Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors by Kaimakis, Polynikis, de Pater, Emma, Eich, Christina, Solaimani Kartalaei, Parham, Kauts, Mari-Liis, Vink, Chris S., van der Linden, Reinier, Jaegle, Martine, Yokomizo, Tomomasa, Meijer, Dies, Dzierzak, Elaine

“…The Gata2 transcription factor is a pivotal regulator of hematopoietic cell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency…”
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Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation by de Pater, Emma, Ciampricotti, Metamia, Priller, Florian, Veerkamp, Justus, Strate, Ina, Smith, Kelly, Lagendijk, Anne Karine, Schilling, Thomas F, Herzog, Wiebke, Abdelilah-Seyfried, Salim, Hammerschmidt, Matthias, Bakkers, Jeroen

“…RATIONALE:The importance for Bmp signaling during embryonic stem cell differentiation into myocardial cells has been recognized. The question when and where…”
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Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence by Guiu, Jordi, Bergen, Dylan J M, De Pater, Emma, Islam, Abul B M M K, Ayllón, Verónica, Gama-Norton, Leonor, Ruiz-Herguido, Cristina, González, Jessica, López-Bigas, Nuria, Menendez, Pablo, Dzierzak, Elaine, Espinosa, Lluis, Bigas, Anna

“…Hematopoietic stem cell (HSC) specification occurs in the embryonic aorta and requires Notch activation; however, most of the Notch-regulated elements…”
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Rotation and Asymmetric Development of the Zebrafish Heart Requires Directed Migration of Cardiac Progenitor Cells by Smith, Kelly A., Chocron, Sonja, von der Hardt, Sophia, de Pater, Emma, Soufan, Alexander, Bussmann, Jeroen, Schulte-Merker, Stefan, Hammerschmidt, Matthias, Bakkers, Jeroen

“…We have used high-resolution 4D imaging of cardiac progenitor cells (CPCs) in zebrafish to investigate the earliest left-right asymmetric movements during…”
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HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo by Imanirad, Parisa, Solaimani Kartalaei, Parham, Crisan, Mihaela, Vink, Chris, Yamada-Inagawa, Tomoko, de Pater, Emma, Kurek, Dorota, Kaimakis, Polynikis, van der Linden, Reiner, Speck, Nancy, Dzierzak, Elaine

“…Hypoxia affects many physiologic processes during early stages of mammalian ontogeny, particularly placental and vascular development. In the adult, the…”
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Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis by Dobrzycki, Tomasz, Mahony, Christopher B., Krecsmarik, Monika, Koyunlar, Cansu, Rispoli, Rossella, Peulen-Zink, Joke, Gussinklo, Kirsten, Fedlaoui, Bakhta, de Pater, Emma, Patient, Roger, Monteiro, Rui

“…Gata2 is a key transcription factor required to generate Haematopoietic Stem and Progenitor Cells (HSPCs) from haemogenic endothelium (HE); misexpression of…”
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S160: GATA2B HAPLOINSUFFICIENCY CAUSES ABERRANT TRANSCRIPTIONAL REGULATORY SIGNATURES IN HSPCS RESULTING IN MYELOID AND ERYTHROID DYSPLASIA IN ZEBRAFISH by Zhang, Wei, Gioacchino, Emanuele, Koyunlar, Cansu, Zink, Joke, De Looper, Hans, Gussinklo, Kirsten J., Hoogenboezem, Remco, Bosch, Dennis, Bindels, Eric, Touw, Ivo P., De Pater, Emma

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PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations by Olofsen, Patricia A., Bosch, Dennis A., Roovers, Onno, van Strien, Paulina M.H., de Looper, Hans W.J., Hoogenboezem, Remco M., Barnhoorn, Sander, Mastroberardino, Pier G., Ghazvini, Mehrnaz, van der Velden, Vincent H.J., Bindels, Eric M.J., de Pater, Emma M., Touw, Ivo P.

“…Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown…”
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MYELODYSPLASTIC SYNDROME AND LEUKEMIA IS A SECONDARY EVENT AFTER BONE MARROW FAILURE IN GATA2 HAPLOINSUFFICIENT MICE by Koyunlar, Cansu, Fernandez-Orth, Juncal, Weiss, Julia, Gioacchino, Emanuele, Looper, HansDe, Andrieux, Geoffrey, Borg, Mariette Ter, Yigit, Baris, Zink, Joke, Hoogenboezem, Remco, Gonzalez-Mendez, Irene, Bindels, Eric, Sanders, Mathijs, Touw, Ivo, Erlacher, Miriam, Pater, Emma De

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GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia by Gioacchino, Emanuele, Zhang, Wei, Koyunlar, Cansu, Zink, Joke, de Looper, Hans, Gussinklo, Kirsten J, Hoogenboezem, Remco, Bosch, Dennis, Bindels, Eric, Touw, Ivo P, de Pater, Emma

“…The transcription factor GATA2 has a pivotal role in haematopoiesis. Heterozygous germline GATA2 mutations result in a syndrome characterized by…”
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