Search Results - "De Palma, Ryan M"

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation by Panneer Selvam, Shanmugam, De Palma, Ryan M, Oaks, Joshua J, Oleinik, Natalia, Peterson, Yuri K, Stahelin, Robert V, Skordalakes, Emmanuel, Ponnusamy, Suriyan, Garrett-Mayer, Elizabeth, Smith, Charles D, Ogretmen, Besim

“…During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called telomeres. Shortened telomeres trigger cell senescence, and cancer…”
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The NMR‐based characterization of the FTY720‐SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET‐PP2A interaction by De Palma, Ryan M., Parnham, Stuart R., Li, Yitong, Oaks, Joshua J., Peterson, Yuri K., Szulc, Zdzislaw M., Roth, Braden M., Xing, Yongna, Ogretmen, Besim

“…ABSTRACT The su(var)3‐9, enhancer of zeste, trithorax (SET)/inhibitor 2 of protein phosphatase 2A (PP2A) oncoprotein binds and inhibits PP2A, composed of…”
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis by Saddoughi, Sahar A., Gencer, Salih, Peterson, Yuri K., Ward, Katherine E., Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M., Thomas, Raquela J., Selvam, Shanmugam P., Senkal, Can E., Garrett‐Mayer, Elizabeth, De Palma, Ryan M., Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A., Stahelin, Robert V., Perrotti, Danilo, Ogretmen, Besim

“…Mechanisms that alter protein phosphatase 2A (PP2A)‐dependent lung tumour suppression via the I2PP2A/SET oncoprotein are unknown. We show here that the tumour…”
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