HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

: Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor‐joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians,...

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Published in:Tissue antigens Vol. 57; no. 4; pp. 308 - 317
Main Authors: Arnaiz-Villena, A., Karin, M., Bendikuze, N., Gomez-Casado, E., Moscoso, J., Silvera, C., Oguz, F.S., Sarper Diler, A., De Pacho, A., Allende, L., Guillen, J., Martinez Laso, J.
Format: Journal Article
Language:English
Published: Copenhagen Munksgaard International Publishers 01-04-2001
Subjects:
Algerians
Alleles
Armenia
Armenians
Berbers
Cretans
Egyptians
Ethnic Groups - genetics
Gene Frequency
Greeks
Haplotypes - immunology
histocompatibility locus HLA
HLA
HLA Antigens - genetics
HLA-A Antigens - genetics
HLA-B Antigens - genetics
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
Humans
Iberians
Iranians
Jews
Kurds
Lebanese
Mediterranean Region
Turkey
Turks
Armenia
Turkey
Mediterranean Region
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Summary:: Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor‐joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians, Jews, Lebanese and other (Eastern and Western) Mediterranean groups seem to share a common ancestry: the older “Mediterranean” substratum. No sign of the postulated Indo‐European (Aryan) invasion (1200 B.C.) is detected by our genetic analysis. It is concluded that this invasion, if occurred, had a relatively few invaders in comparison to the already settled populations, i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present‐day Kurdish, Armenian and Turkish populations.
Bibliography:ark:/67375/WNG-LLBJTFS3-H
ArticleID:TAN570403
istex:F2B990329A245DEEB04220B5B3389DD2BDAB0DA4
The contribution by Antonio Arnaiz‐Villena and Mahmut Karin is equal and the order of authorship is arbitrary
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ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2001.057004308.x